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Prof. Bommhardt

apl. Prof. Dr. rer. nat. habil. Ursula Bommhardt

Medizinische Fakultät
Institut für Molekulare und Klinische Immunologie (IMKI)
Haus 26, Leipziger Str. 44, 39120, Magdeburg,

apl. Prof. Dr. rer. nat. habil. Ursula Bommhardt

Medizinische Fakultät
Institut für Molekulare und Klinische Immunologie (IMKI)
Haus 26, Leipziger Str. 44, 39120, Magdeburg,
Tel.: +49 391 67 13311
Fax: +49 391 67 15852
Projekte
Publikationen

2017

Abstrakt
Mirdamadi, Yasaman Sadat;  Thielitz, Anja;  Goihl, Alexander;  Guttek, Karina;  Zouboulis, Christos C.;  Reinhold, Dirk;  Bommhardt, Ursula;  Quist, Sven Roy;  Gollnick, Harald 

Insights into the mechanism of action of insulin-like growth factor-1 and insulin in human T cells in vitro
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 26.2017, 3, P081 (OP06/06), S. E35; http://onlinelibrary.wiley.com/doi/10.1111/exd.13280/full

Mirdamadi, Yasaman Sadat;  Thielitz, Anja;  Wiede, Antje;  Goihl, Alexander;  Zouboulis, Christos C.;  Reinhold, Dirk;  Bommhardt, Ursula;  Quist, Sven Roy;  Gollnick, Harald 

Insights into the mechanism of action of isotretinoin in human sebocytes in vitro
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 26.2017, 3, P082, S. E35-E36; http://onlinelibrary.wiley.com/doi/10.1111/exd.13280/full

Begutachteter Zeitschriftenartikel
Mirdamadi, Yasaman Sadat;  Thielitz, Anja;  Wiede, Antje;  Goihl, Alexander;  Zouboulis, Christos C.;  Bommhardt, Ursula;  Quist, Sven Roy;  Gollnick, Harald 

Effects of isotretinoin on the phosphoinositide-3-kinase/Akt/FoxO1 pathway and molecular functions of SZ95 sebocytes in vitro
In: Journal of clinical & experimental dermatology research - Los Angeles, CA: Omics international, Bd. 8.2017, 3, Art.-Nr. 1000399, insges. 12 S.; http://dx.doi.org/10.4172/2155-9554.1000399

Mirdamadi, Yasaman Sadat;  Bommhardt, Ursula;  Goihl, Alexander;  Guttek, Karina;  Zouboulis, Christos C.;  Quist, Sven Roy;  Gollnick, Harald 

Insulin and insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro
In: Dermato-endocrinology - Austin, Tex: Landes Bioscience, Bd. 9.2017, Art.-Nr. e1356518, insges. 13 S.; http://dx.doi.org/10.1080/19381980.2017.1356518

2016

Begutachteter Zeitschriftenartikel
Lowinus, Theresa;  Bose, Tanima;  Busse, Stefan;  Busse, Mandy;  Reinhold, Dirk;  Schraven, Burkhart;  Bommhardt, Ursula H. H. 

Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness
In: OncoTarget : open access impact journal. - [S.l.] : Impact Journals LLC, Bd. 7.2016, 33, S. 53797-53807

2015

Abstrakt
Mirdamadi, Yasaman;  Thielitz, Anja;  Wiede, Antje;  Goihl, Alexander;  Zouboulis, Christos C.;  Reinhold, Dirk;  Bommhardt, Ursula;  Quist, Sven;  Gollnick, Harald 

Effects of isotretinoin on FoxO1 transcriptional regulation and molecular functions of SZ95 sebocytes
In: Experimental dermatology : the official journal of the European Immunodermatology Society. - Oxford : Wiley-Blackwell; Bd. 24.2015, 3, P068, S. E12

Begutachteter Zeitschriftenartikel
Mirdamadi, Yasaman;  Thielitz, Anja;  Wiede, Antje;  Goihl, Alexander;  Papakonstantinou, Eleni;  Hartig, Roland;  Zouboulis, Christos C.;  Reinhold, Dirk;  Simeoni, Luca;  Bommhardt, Ursula;  Quist, Sven;  Gollnick, Harald 

Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro
In: Molecular and cellular endocrinology. - Amsterdam [u.a.] : Elsevier Science, Bd. 415.2015, S. 32-44

Linker, Ralf A.;  Lee, De-Hyung;  Flach, Anne-Christine;  Litke, Tanja;  Brandt, Jens van den;  Reichardt, Holger M.;  Lingner, Thomas;  Bommhardt, Ursula;  Sendtner, Michael;  Gold, Ralf;  Flügel, Alexander;  Lühder, Fred 

Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage
In: European journal of immunology. - Weinheim : Wiley-VCH, Bd. 45.2015, 5, S. 1326-1338

Busse, Stefan;  Steiner, Johann;  Glorius, Sarah;  Dobrowolny, Henrik;  Greiner-Bohl, Sabrina;  Mawrin, Christian;  Bommhardt, Ursula;  Hartig, Roland;  Bogerts, Bernhard;  Busse, Mandy 

VGF expression by T lymphocytes in patients with Alzheimer's disease
In: OncoTarget : open access impact journal. - [S.l.] : Impact Journals LLC, Bd. 6.2015, 17, S. 14843-14851

2014

Abstrakt
Lühder, Fred;  Linker, Ralf;  Lee, De-hyung;  Reichardt, Holger;  Bommhardt, Ursula;  Gold, Ralf;  Flügel, Alexander 

Critical role of thymocyte-derived brain-derived neurotrophic factor in T cell maturation
In: Journal of neuroimmunology : official journal of the International Society for Neuroimmunology. - Amsterdam [u.a.] : Elsevier Science, Bd. 275.2014, 1/2, S. 202-203

Begutachteter Zeitschriftenartikel
Busse, Stefan;  Steiner, Johann;  Micheel, Justus;  Dobrowolny, Henrik;  Mawrin, Christian;  Krause, Tim J.;  Adamaszek, Michael;  Bogerts, Bernhard;  Bommhardt, Ursula;  Hartig, Roland;  Busse, Mandy 

Age-related increase of VGF-expression in T lymphocytes
In: Aging. - [S.l.] : Impact Journals, LLC, Bd. 6.2014, 6, S. 440-453

Kahlfuß, Sascha;  Simma, Narasimhulu;  Mankiewicz, Judith;  Bose, Tanima;  Lowinus, Theresa;  Klein-Hessling, Stefan;  Sprengel, Rolf;  Schraven, Burkhart;  Heine, Martin;  Bommhardt, Ursula 

Immunosuppression by N-Methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells
In: Molecular and cellular biology. - Washington, DC : Soc, Bd. 34.2014, 5, S. 820-831

Simma, Narasimhulu;  Bose, Tanima;  Kahlfuß, Sascha;  Mankiewicz, Judith;  Lowinus, Theresa;  Lühder, Fred;  Schüler, Thomas;  Schraven, Burkhart;  Heine, Martin;  Bommhardt, Ursula 

NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells
In: Cell communication and signaling. - London : Biomed Central; Bd. 12.2014, Art.-Nr. 75, insges. 13 S.

Dissertation
Bose, Tanima;  Bommhardt, Ursula [Gutachter] 

Crosstalk between NMDAR antagonists and potassium channels in murine and human lymphocytes
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014; 92 Bl.: graph. Darst.; 30 cm

2013

Abstrakt
Patra, Amiya K.;  Avots, Andris;  Zahedi, René P.;  Schüler, Thomas;  Sickmann, Albert;  Bommhardt, Ursula;  Serfling, Edgar 

Interleukin-7-mediated NFAT activation sets the threshold for T cell development
In: Cytokine. - London : Academic Press; Bd. 63.2013, 3, Abs. 196, S. 289

Begutachteter Zeitschriftenartikel
Patra, Amiya Kumar;  Avots, Andris;  Zahedi, René Peiman;  Schüler, Thomas;  Sickmann, Albert;  Bommhardt, Ursula;  Serfling, Edgar 

An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development
In: Nature immunology - New York, NY: SpringerNature, Bd. 14.2013, 2, S. 127-135; http://dx.doi.org/10.1038/ni.2507

2012

Dissertation
Pierau, Mandy;  Bommhardt, Ursula [Gutachter] 

Proteinkinase B- und TGFβ1-Signalwege - Untersuchungen zu ihrer Interaktion bei der Th-Zelldifferenzierung
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2012; 143 Bl.: graph. Darst.

Originalartikel in begutachteter internationaler Zeitschrift
Pierau, Mandy;  Na, Shin-Young;  Simma, Narasimhulu;  Lowinus, Theresa;  Marx, Alexander;  Schraven, Burkhart;  Bommhardt, Ursula H. 

Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function
In: European journal of immunology. - Weinheim : Wiley VCH, Bd. 42.2012, 12, S. 3381-3393

2011

Dissertation
Engelmann, Swen;  Bommhardt, Ursula [Gutachter] 

Einfluss von Proteinkinase B (PKB/Akt) auf Differenzierungsprozesse von T-Helferzellen und den Verlauf der Experimentellen Autoimmunen Enzephalomyelitis (EAE)
In: Magdeburg Univ., Fak. für Naturwiss., Diss., 2011, III, 104 Bl., graph. Darst., 30 cm

Originalartikel in begutachteter internationaler Zeitschrift
Bhattacharyya, Sankar;  Deb, Jolly;  Patra, Amiya K.;  Pham, Duong Anh Thuy;  Chen, Wen;  Väth, Martin;  Berberich-Siebelt, Friederike;  Klein-Hessling, Stefan;  Lamperti, Edward D.;  Reifenberg, Kurt;  Jellusova, Julia;  Schweizer, Astrid;  Nitschke, Lars;  Leich, Ellen;  Rosenwald, Andreas;  Brunner, Cornelia;  Engelmann, Swen;  Bommhardt, Ursula;  Avots, Andris;  Müller, Martin R.;  Kondo, Eisaku;  Serfling, Edgar 

NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network
In: The journal of experimental medicine. - New York, NY : Rockefeller Univ. PressThe journal of experimental medicine <New York, NY>, Bd. 208.2011, 4, S. 823-839

2010

Dissertation
Drewes, Thomas;  Bommhardt, Ursula [Gutachter] 

Cross-talk of protein kinase B (PKB/Akt) with the transcription factor NFAT and the Src kinase Fyn in T lymphocytes
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2010; III, 116 Bl.: graph. Darst.; 30 cm

Originalartikel in begutachteter internationaler Zeitschrift
Bommhardt, Ursula 

Hedgehog signalling in T-cell development: A non-redundant role for Gli1
In: Cell cycle . - Georgetown, Tex. : Landes Bioscience, Bd. 9.2010, 22, S. 4428

Bommhardt, Ursula 

Hedgehog signalling in T-cell development: A non-redundant role for Gli1.
In: Cell Cycle. 2010 Nov 15;9(22):4433-4432.

2009

Originalartikel in begutachteter internationaler Zeitschrift
Bajbouj, Khuloud;  Pöhlmann, Angela;  Küster, Dörthe;  Drewes, Thomas;  Haase, Kathrin;  Hartig, Roland;  Teller, Anne;  Kliche, Stefanie;  Walluscheck, Diana;  Ivanovska, Jelena;  Chakilam, Saritha;  Ulitzsch, Annika;  Bommhardt, Ursula;  Leverkus, Martin;  Roessner, Albert;  Schneider-Stock, Regine 

Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNF[alpha]-induced apoptosis in colorectal tumor cells
In: The American journal of pathology . - Bethesda, Md. : American Society for Investigative Pathology, Bd. 175.2009, 2, S. 557-570

Pierau, Mandy;  Engelmann, Swen;  Reinhold, Dirk;  Lapp, Thabo;  Schraven, Burkhart;  Bommhardt, Ursula 

Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 10, S. 6124-6134

2008

Originalartikel in begutachteter internationaler Zeitschrift
Bekeredjian-Ding, Isabelle;  Doster, Anne;  Schiller, Martin;  Heyder, Petra;  Lorenz, Hanns-Martin;  Schraven, Burkhart;  Bommhardt, Ursula;  Heeg, Klaus 

TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 181.2008, 12, S. 8267-8277

2007

Originalartikel in begutachteter internationaler Zeitschrift
Saez-Rodriguez, Julio;  Simeoni, Luca;  Lindquist, Jonathan;  Hemenway, Rebecca;  Bommhardt, Ursula;  Arndt, Börge;  Haus, Utz-Uwe;  Weismantel, Robert;  Gilles, Ernst D.;  Klamt, Steffen;  Schraven, Burkhart 

A logical model provides insights into T cell receptor signaling
In: Public Library of Science : PLoS Computational Biology . - San Francisco, Calif. : Public Library of Science, Bd. 3.2007, 8, insges. 11 S.; Abstract unter URL: http://dx.doi.org/10.1371/journal.pcbi.0030163

Bommhardt, Ursula 

Glis: novel modulators of TCR signaling?
In: Blood: the journal of hematology - Washington, DC: American Society of Hematology, Bd. 109.2007, 9, S. 3618-3619; http://bloodjournal.hematologylibrary.org/content/vol109/issue9/

Bommhardt, Ursula 

Glis: novel modulators of TCR signaling?
In: Blood : the journal of hematology - Washington, DC : American Society of Hematology, Bd. 109.2007, 9, S. 3618-3619

Masse, Guillemette X.;  Corcuff, Erwan;  Decaluwe, Hélène;  Bommhardt, Ursula;  Lantz, Olivier;  Buer, Jan;  DiSanto, James P. 

[Gamma]c cytokines provide multiple homeostatic signals to naive CD4+ T cells
In: European journal of immunology - Weinheim : Wiley VCH, Bd. 37.2007, 9, S. 2606-2616

Masse, Guillemette X.;  Corcuff, Erwan;  Decaluwe, Hélène;  Bommhardt, Ursula;  Lantz, Olivier;  Buer, Jan;  DiSanto, James P. 

[Gamma]c cytokines provide multiple homeostatic signals to naive CD4+ T cells
In: European journal of immunology - Weinheim: Wiley VCH, Bd. 37.2007, 9, S. 2606-2616; http://www3.interscience.wiley.com/cgi-bin/abstract/114801695/ABSTRACT

2006

Originalartikel in begutachteter internationaler Zeitschrift
Patra, Amiya Kumar;  Drewes, Thomas;  Engelmann, Swen;  Chuvpilo, Sergei;  Kishi, Hiroyuki;  Hünig, Thomas;  Serfling, Edgar;  Bommhardt, Ursula H. 

PKB rescues Calcineurin/NFAT-induced arrest of Rag expression and Pre-T cell differentiation
In: The journal of immunology : official journal of the American Association of Immunologists - Rockville, Md : American Association of Immunologists, Bd. 177.2006, 7, S. 4567-4576

Patra, Amiya Kumar;  Drewes, Thomas;  Engelmann, Swen;  Chuvpilo, Sergei;  Kishi, Hiroyuki;  Hünig, Thomas;  Serfling, Edgar;  Bommhardt, Ursula H. 

PKB rescues Calcineurin/NFAT-induced arrest of Rag expression and Pre-T cell differentiation
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md: American Association of Immunologists, Bd. 177.2006, 7, S. 4567-4576; http://www.jimmunol.org/cgi/content/abstract/177/7/4567

Kooperationen
  • Dr. Michael Kreutz, IfN
  • Prof. E. Serfling, Würzburg
Profil
Zelluläre und molekulare Immunologie
  • T-Zellreifung
  • T-Zellaktivierung- und differenzierung: Th17, Treg...
  • Signaltransduktion in T-Zellen, ins. PKB/Akt-Signalgebung
  • Autoimmunität und Tumorgenese
Service
Phänotypische und funktionelle Analyse von Immunzellen
Vita
presse

Letzte Änderung: 28.08.2017 - Ansprechpartner:

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