Proteasome inhibition potentiates Kv1.3 potassium channel expression as therapeutic target in drug-sensitive and -resistant human melanoma cells

Cammann, Clemens; Kulla, Jonas; Wiebusch, Lüder; Walz, Christian; Zhao, Fang; Lowinus, Theresa; Topfstedt, Eylin; Mishra, Neha; Henklein, Petra; Bommhardt, Ursula; Bossaller, Lukas Friedrich Magnus; Hagemeier, Christian; Schadendorf, Dirk; Schmidt, Boris; Paschen, Annette; Seifert, Ulrike

In: Biomedicine & pharmacotherapy - Amsterdam [u.a.] : Elsevier Science, Bd. 168 (2023), Artikel 115635, insges. 10 S.

Publikationslink

Y192 within the SH2 domain of Lck regulates TCR signaling downstream of PLC-γ1 and thymic selection

Kästle, Matthias; Merten, Camilla; Hartig, Roland; Plaza Sirvent, Carlos; Schmitz, Ingo; Bommhardt, Ursula; Schraven, Burkhart; Simeoni, Luca

In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 13, insges. 15 S.

Publikationslink

Kv1.3 potassium channels - promising therapeutic targets in hematological malignancies

Lowinus, Theresa; Bose, Tanima; Simeoni, Luca; Schraven, Burkhart; Bommhardt, Ursula

In: Journal of cellular signaling - Wilmington: Scientific Archives LLC, 2020, Bd. 1 (2020), 3, S. 79-86

Publikationslink

Beyond TCR signaling - emerging functions of Lck in cancer and immunotherapy

Bommhardt, Ursula; Schraven, Burkhart; Simeoni, Luca

In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 14, Art.-Nr. 3500, insges. 18 S.

Publikationslink

Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling

Lowinus, Theresa; Heidel, Florian; Bose, Tanima; Nimmagadda, Subbaiah Chary; Schnöder, Tina; Cammann, Clemens; Schmitz, Ingo; Seifert, Ulrike; Fischer, Thomas; Schraven, Burkhart; Bommhardt, Ursula

In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 17.2019, Art.-Nr. 5, insges. 13 S.

Publikationslink

CD45 in human physiology and clinical medicine

Rheinländer, Andreas; Schraven, Burkhart; Bommhardt, Ursula

In: Immunology letters - Amsterdam [u.a.]: Elsevier Science, Bd. 196.2018, S. 22-32

Publikationslink

Insights into the mechanism of action of insulin-like growth factor-1 and insulin in human T cells in vitro

Mirdamadi, Yasaman Sadat; Thielitz, Anja; Goihl, Alexander; Guttek, Karina; Zouboulis, Christos C.; Reinhold, Dirk; Bommhardt, Ursula; Quist, Sven Roy; Gollnick, Harald

In: Experimental dermatology : the official journal of the European Immunodermatology Society - Oxford : Wiley-Blackwell, Bd. 26.2017, 3, P081 (OP06/06), S. E35

Publikationslink

Insights into the mechanism of action of isotretinoin in human sebocytes in vitro

Mirdamadi, Yasaman Sadat; Thielitz, Anja; Wiede, Antje; Goihl, Alexander; Zouboulis, Christos C.; Reinhold, Dirk; Bommhardt, Ursula; Quist, Sven Roy; Gollnick, Harald

In: Experimental dermatology : the official journal of the European Immunodermatology Society - Oxford : Wiley-Blackwell, Bd. 26.2017, 3, P082, S. E35-E36

Publikationslink

Effects of isotretinoin on the phosphoinositide-3-kinase/Akt/FoxO1 pathway and molecular functions of SZ95 sebocytes in vitro

Mirdamadi, Yasaman Sadat; Thielitz, Anja; Wiede, Antje; Goihl, Alexander; Zouboulis, Christos C.; Bommhardt, Ursula; Quist, Sven Roy; Gollnick, Harald

In: Journal of clinical & experimental dermatology research - Los Angeles, CA : Omics international - Bd. 8.2017, 3, Art.-Nr. 1000399, insges. 12 S.

Publikationslink

Insulin and insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro

Mirdamadi, Yasaman Sadat; Bommhardt, Ursula; Goihl, Alexander; Guttek, Karina; Zouboulis, Christos C.; Quist, Sven Roy; Gollnick, Harald

In: Dermato-endocrinology - Austin, Tex: Landes Bioscience, Bd. 9.2017, Art.-Nr. e1356518, insges. 13 S.

Publikationslink

Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness

Lowinus, Theresa; Bose, Tanima; Busse, Stefan Gregor; Busse, Mandy; Reinhold, Dirk; Schraven, Burkhart; Bommhardt, Ursula H. H.

In: OncoTarget - [S.l.]: Impact Journals LLC, 2010, Bd. 7 (2016), 33, S. 53797-53807

Publikationslink

Effects of isotretinoin on FoxO1 transcriptional regulation and molecular functions of SZ95 sebocytes

Mirdamadi, Yasaman Sadat; Thielitz, Anja; Wiede, Antje; Goihl, Alexander; Zouboulis, Christos C.; Reinhold, Dirk; Bommhardt, Ursula; Quist, Sven Roy; Gollnick, Harald

In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 24.2015, 3, P068, S. E12

Publikationslink

Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro

Mirdamadi, Yasaman Sadat; Thielitz, Anja; Wiede, Antje; Goihl, Alexander; Papakonstantinou, Eleni; Hartig, Roland; Zouboulis, Christos C.; Reinhold, Dirk; Simeoni, Luca; Bommhardt, Ursula; Quist, Sven Roy; Gollnick, Harald

In: Molecular and cellular endocrinology - Amsterdam [u.a.]: Elsevier Science, Bd. 415 (2015), S. 32-44

Publikationslink

Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage

Linker, Ralf; Lee, De-Hyung; Flach, Anne-Christine; Litke, Tanja; Brandt, Jens; Reichardt, Holger Michael; Lingner, Thomas; Bommhardt, Ursula; Sendtner, Michael; Gold, Ralf; Flügel, Alexander; Lühder, Fred

In: European journal of immunology - Weinheim: Wiley-VCH, Bd. 45.2015, 5, S. 1326-1338

Publikationslink

VGF expression by T lymphocytes in patients with Alzheimer's disease

Busse, Stefan Gregor; Steiner, Johann; Glorius, Sarah; Dobrowolny, Henrik; Greiner-Bohl, Sabrina; Mawrin, Christian; Bommhardt, Ursula; Hartig, Roland; Bogerts, Bernhard; Busse, Mandy

In: OncoTarget - [S.l.]: Impact Journals LLC, Bd. 6 (2015), 17, S. 14843-14851

Publikationslink

Critical role of thymocyte-derived brain-derived neurotrophic factor in T cell maturation

Lühder, Fred; Linker, Ralf; Lee, De-Hyung; Reichardt, Holger Michael; Bommhardt, Ursula; Gold, Ralf; Flügel, Alexander

In: Journal of neuroimmunology: official journal of the International Society for Neuroimmunology - Amsterdam [u.a.]: Elsevier Science, 1981, Bd. 275.2014, 1/2, S. 202-203

Publikationslink

Immunosuppression by N-Methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells

Kahlfuß, Sascha; Simma, Narasimhulu; Mankiewicz, Judith; Bose, Tanima; Lowinus, Theresa; Klein-Heßling, Stefan; Sprengel, Rolf; Schraven, Burkhart; Heine, Martin; Bommhardt, Ursula

In: Molecular and cellular biology - Washington, DC: Soc., Bd. 34 (2014), 5, S. 820-831, insges. 12 S.

Publikationslink

NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells

Simma, Narasimhulu; Bose, Tanima; Kahlfuß, Sascha; Mankiewicz, Judith; Lowinus, Theresa; Lühder, Fred; Schüler, Thomas; Schraven, Burkhart; Heine, Martin; Bommhardt, Ursula

In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 12.2014, Art.-Nr. 75, insges. 13 S.

Publikationslink

Age-related increase of VGF-expression in T lymphocytes

Busse, Stefan Gregor; Steiner, Johann; Micheel, Justus; Dobrowolny, Henrik; Mawrin, Christian; Krause, Tim Johannes; Adamaszek, Michael; Bogerts, Bernhard; Bommhardt, Ursula; Hartig, Roland; Busse, Mandy

In: Aging - [S.l.]: Impact Journals, LLC, Bd. 6 (2014), 6, S. 440-453

Publikationslink

Crosstalk between NMDAR antagonists and potassium channels in murine and human lymphocytes

Bose, Tanima; Bommhardt, Ursula

In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014, 92 Bl., graph. Darst., 30 cm

Interleukin-7-mediated NFAT activation sets the threshold for T cell development

Patra, Amiya K.; Avots, Andris; Zahedi, René P.; Schüler, Thomas; Sickmann, Albert; Bommhardt, Ursula; Serfling, Edgar

In: Cytokine. - London : Academic Press; Bd. 63.2013, 3, Abs. 196, S. 289

Publikationslink

An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development

Patra, Amiya Kumar; Avots, Andris; Zahedi, René Peiman; Schüler, Thomas; Sickmann, Albert; Bommhardt, Ursula; Serfling, Edgar

In: Nature immunology - New York, NY: SpringerNature, Bd. 14.2013, 2, S. 127-135

Publikationslink

Proteinkinase B- und TGFβ1-Signalwege - Untersuchungen zu ihrer Interaktion bei der Th-Zelldifferenzierung

Pierau, Mandy; Bommhardt, Ursula

In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2012, 143 Bl.

Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function

Pierau, Mandy; Na, Shin-Young; Simma, Narasimhulu; Lowinus, Theresa; Marx, Alexander; Schraven, Burkhart; Bommhardt, Ursula H.

In: European journal of immunology - Weinheim: Wiley, Bd. 42 (2012), 12, S. 3381-3393

Publikationslink

Einfluss von Proteinkinase B (PKB/Akt) auf Differenzierungsprozesse von T-Helferzellen und den Verlauf der Experimentellen Autoimmunen Enzephalomyelitis (EAE)

Engelmann, Swen; Bommhardt, Ursula

In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2011, III, 104 Bl., graph. Darst., 30 cm

NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network

Bhattacharyya, Sankar; Deb, Jolly; Patra, Amiya Kumar; Pham, Duong Anh Thuy; Chen, Wen; Väth, Martin; Berberich-Siebelt, Friederike; Klein-Heßling, Stefan; Lamperti, Edward D.; Reifenberg, Kurt; Jellúšová, Júlia; Schweizer, Astrid; Nitschke, Lars; Leich-Zbat, Ellen; Rosenwald, Andreas; Brunner, Cornelia; Engelmann, Swen; Bommhardt, Ursula; Avots, Andris; Müller, Martin R.; Kondo, Eisaku; Serfling, Edgar

In: The journal of experimental medicine - New York, NY: Rockefeller Univ. Press, Bd. 208 (2011), 4, S. 823-839

Publikationslink

Cross-talk of protein kinase B (PKB/Akt) with the transcription factor NFAT and the Src kinase Fyn in T lymphocytes

Drewes, Thomas; Bommhardt, Ursula

In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2010, III, 116 Bl., graph. Darst., 30 cm

Hedgehog signalling in T-cell development: A non-redundant role for Gli1.

Bommhardt, Ursula

In: Cell Cycle. 2010 Nov 15;9(22):4433-4432.

Hedgehog signalling in T-cell development: A non-redundant role for Gli1

Bommhardt, Ursula

In: Cell cycle . - Georgetown, Tex. : Landes Bioscience, Bd. 9.2010, 22, S. 4428

Publikationslink

Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation

Pierau, Mandy; Engelmann, Swen; Reinhold, Dirk; Lapp, Thabo; Schraven, Burkhart; Bommhardt, Ursula

In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 10, S. 6124-6134

Publikationslink

RETRACTED: Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNF[alpha]-induced apoptosis in colorectal tumor cells

Bajbouj, Khuloud; Pöhlmann, Angela; Jechorek, Dörthe; Drewes, Thomas; Haase, Kathrin; Hartig, Roland; Teller, Anne; Kliche, Stefanie; Walluscheck, Diana; Ivanovska, Jelena; Chakilam, Saritha; Ulitzsch, Annika; Bommhardt, Ursula; Leverkus, Martin; Roessner, Albert; Schneider-Stock, Regine

In: The American journal of pathology - New York, NY [u.a.]: Elsevier, Bd. 175 (2009), 2, S. 557-570

TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells

Bekeredjian-Ding, Isabelle; Doster, Anne; Schiller, Martin; Heyder, Petra; Lorenz, Hanns-Martin; Schraven, Burkhart; Bommhardt, Ursula; Heeg, Klaus

In: The journal of immunology - Rockville, Md.: American Association of Immunologists, Bd. 181 (2008), 12, S. 8267-8277

A logical model provides insights into T cell receptor signaling

Sáez Rodríguez, Julio; Simeoni, Luca; Lindquist, Jonathan A.; Hemenway, Rebecca; Bommhardt, Ursula; Arndt, Börge; Haus, Utz-Uwe; Weismantel, Robert; Gilles, Ernst D.; Klamt, Steffen; Schraven, Burkhart

In: PLoS Computational Biology - San Francisco, Calif: Public Library of Science, Bd. 3(2007), 8, insges. 11 S.

Publikationslink

[Gamma]c cytokines provide multiple homeostatic signals to naive CD4+ T cells

Masse, Guillemette X.; Corcuff, Erwan; Decaluwe, Hélène; Bommhardt, Ursula; Lantz, Olivier; Buer, Jan; DiSanto, James P.

In: European journal of immunology - Weinheim: Wiley, Bd. 37 (2007), 9, S. 2606-2616

Publikationslink

Glis: novel modulators of TCR signaling?

Bommhardt, Ursula

In: Blood: the journal of hematology / American Society of Hematology. William Dameshek, founding ed. - Washington, DC: American Society of Hematology, Bd. 109 (2007), 9, S. 3618-3619

Publikationslink

PKB rescues Calcineurin/NFAT-induced arrest of Rag expression and Pre-T cell differentiation

Patra, Amiya Kumar; Drewes, Thomas; Engelmann, Swen; Chuvpilo, Sergei; Kishi, Hiroyuki; Hünig, Thomas; Serfling, Edgar; Bommhardt, Ursula H.

In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 177.2006, 7, S. 4567-4576

Publikationslink