Proteomic profiling and cytokine analysis reveals molecular signatures and inflammatory factors associated with thrombosis in JAK2-V617F positive myeloproliferative neoplasm (MPN) cohorts

Bhuria, Vikas; Ham, Marco Adrianus; Vogel, Katrin; Waldleben, Ana; Zeremski, Vanja; Böttcher, Martin; Brunner-Weinzierl, Monika; Mougiakakos, Dimitrios; Schraven, Burkhart; Jänsch, Lothar; Fischer, Thomas

In: Blood - Washington, DC : American Society of Hematology, Bd. 142 (2023), Heft Supplement 1, Artikel 6340, insges. 2 S.

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JAK2-V617F promotes up-regulation of pro-inflammatory cytokines including IL-1 upon adhesion-induced activation of β1/β2 Integrins

Baldauf, Conny K.; Charakopoulos, Emmanouil; Böttcher, Martin; Zeremski, Vanja; Mougiakakos, Dimitrios; Schraven, Burkhart; Fischer, Thomas

In: Blood - Washington, DC : American Society of Hematology, Bd. 142 (2023), Heft Supplement 1, Artikel 2749, insges. 3 S.

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Dependence of pathogenic T helper cells on lipid receptors during house dust mite allergic airway inflammation

Krone, Anna; Schreiber, Simon; Negele, Jonas; Franz, Tobias; Kotrba, Johanna; Marks, Anna; Roder, Marc; Sammt, Anja; Jantz-Naeem, Nouria; Garbers, Christoph; Geffers, Robert; Schraven, Burkhart; Müller, Andreas Johann; Dudeck, Anne; Kahlfuß, Sascha

In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 53 (2023), Heft Suppl. 2, S. 377, Artikel P 391

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Allgemeine Kenntnisse zu häufig angewandten Testverfahren in der rheumatologisch-immunologischen Diagnostik und Forschung - General knowledge of frequently applied test procedures in rheumatological and immunological diagnostics and research

Reinhold, Dirk; Reinhold, Annegret; Schraven, Burkhart; Feist, Eugen

In: Zeitschrift für Rheumatologie - Darmstadt : Steinkopff, Bd. 82 (2023), Heft 4, S. 278-284

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Zinc aspartate induces proliferation of resting and antigen-stimulated human PBMC under high-density cell culture condition

Guttek, Karina; Reinhold, Annegret; Grüngreiff, Kurt; Schraven, Burkhart; Reinhold, Dirk

In: Journal of trace elements in medicine and biology - München : Elsevier, Bd. 77 (2023), Artikel 127152

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Patterns of allergic sensitization in adults with severe asthma - the ATLAS non-interventional study

Lücke, Eva; Schraven, Burkhart; Borucki, Katrin; Lux, Anke; Reinhold, Dirk; Wu, Qingyu; Schreiber, Jens

In: Journal of asthma - Philadelphia, Pa. : Taylor & Francis, Bd. 60 (2023), Heft 11, S. 2021-2029

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Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults

Raschick, Matthias; Richter, Anni; Fischer, Larissa; Knopf, Lea; Schult, Annika; Yakupov, Renat; Behnisch, Gusalija; Guttek, Karina; Düzel, Emrah; Dunay, Ildikò Rita; Seidenbecher, Constanze; Schraven, Burkhart; Reinhold, Dirk; Schott, Björn H.

In: Journal of neural transmission - Wien [u.a.] : Springer, Bd. 130 (2023), Heft 8, S. 989-1002

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Antibody properties associate with clinical phenotype in LGI1 encephalitis

Ludewig, Susann; Salzburger, Leonie; Goihl, Alexander; Rohne, Jana; Leypoldt, Frank; Bittner, Daniel Markus; Düzel, Emrah; Schraven, Burkhart; Reinhold, Dirk; Korte, Martin; Körtvélyessy, Péter

In: Cells - Basel : MDPI, Bd. 12 (2023), Heft 2, Artikel 282, insges. 15 S.

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TIGIT signaling and its influence on T cell metabolism and immune cell function in the tumor microenvironment

Jantz-Naeem, Nouria; Böttcher-Loschinski, Romy; Borucki, Katrin; Mitchell-Flack, Marisa; Böttcher, Martin; Schraven, Burkhart; Mougiakakos, Dimitrios; Kahlfuß, Sascha

In: Frontiers in oncology - Lausanne : Frontiers Media, Bd. 13 (2023), Artikel 1060112, insges. 11 S.

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How ITD insertion sites orchestrate the biology and disease of FLT3-ITD-mutated acute myeloid leukemia

Haage, Tobias Ronny; Schraven, Burkhart; Mougiakakos, Dimitrios; Fischer, Thomas

In: Cancers - Basel : MDPI, Bd. 15 (2023), Heft 11, Artikel 2991, insges. 15 S.

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Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate

Baars, Iris; Jaedtka, Moritz; Dewitz, Leon-Alexander; Fu, Yan; Franz, Tobias; Mohr, Juliane; Gintschel, Patricia; Berlin, Hannes; Degen, Angelina; Freier, Sandra; Rygol, Stefan; Schraven, Burkhart; Kahlfuß, Sascha; Zandbergen, Ger; Müller, Andreas Johann

In: JCI insight - Ann Arbor, Michigan : JCI Insight, Bd. 8 (2023), Heft 14, Artikel e169020, insges. 20 S.

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Effector function of natural killer cells is suppressed in acute myeloid leukemia

Höchst, Bastian; Baumann, Tobias; Rothfuß, C.; Donakonda, Sainitin; Brauchle, Bettina; Marcinek, Anetta; Urban, Christian; Mergner, J.; Kearney, C.; Hecker, Judith; Götze, Katharina; Pedde, Anna-Marie; Bücklein, Veit Leonhard; Böttcher, Jan; Jacobs, Roland; Simeoni, Luca; Schraven, Burkhart; Pichlmair, Andreas; Subklewe, Marion; Knolle, Percy A.

In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft Suppl. 1, S. 401-402, Artikel P 290

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IgE-mediated sensitization towards frequent and rare allergens in severe asthmatics - the ATLAS project

Schreiber, Jens; Thurm, Christoph; Reinhold, Dirk; Luecke, Eva; Schraven, Burkhart; Wu, Qingyu; Lux, Anke; Mailänder, Claudia

In: American journal of respiratory and critical care medicine - New York, NY : American Thoracic Society, Bd. 205 (2022), Artikel A5703, insges. 1 S.

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Homologous and heterologous anti-COVID-19 vaccination does not induce new-onset formation of autoantibodies typically accompanying lupus erythematodes, rheumatoid arthritis, celiac disease and antiphospholipid syndrome

Thurm, Christoph; Reinhold, Annegret; Borucki, Katrin; Kahlfuß, Sascha; Feist, Eugen; Schreiber, Jens; Reinhold, Dirk; Schraven, Burkhart

In: Vaccines - Basel: MDPI, 2013, Bd. 10 (2022), 2, insges. 16 S.

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Ionic mitigation of CD4 + T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc

Krone, Anna; Fu, Yanpeng; Schreiber, Simon; Kotrba, Johanna; Borde, Loisa; Nötzold, Aileen; Thurm, Christoph; Negele, Jonas; Franz, Tobias; Stegemann-Koniszewski, Sabine; Schreiber, Jens; Garbers, Christoph; Shukla, Aniruddh; Geffers, Robert; Schraven, Burkhart; Reinhold, Dirk; Dudeck, Anne; Reinhold, Annegret; Müller, Andreas Johann; Kahlfuß, Sascha

In: Scientific reports - [London] : Macmillan Publishers Limited, part of Springer Nature, Bd. 12 (2022), Artikel 1943, insges. 14 S.

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Robust induction of neutralizing antibodies against the SARS-CoV-2 Delta variant after homologous Spikevax or heterologous Vaxzevria-Spikevax vaccination

Hammerschmidt, Swantje Iris Anna-Dorothea; Thurm, Christoph; Bos̆njak, Berislav; Bernhardt, Günter; Reinhold, Annegret; Willenzon, Stefanie; Ritter, Christiane; Reinhold, Dirk; Schraven, Burkhart; Förster, Reinhold

In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft 2, S. 356-359

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A cysteine residue within the kinase domain of Zap70 regulates Lck activity and proximal TCR signaling

Schultz, Annika; Schnurra, Marvin; El-Bizri, Ali; Woessner, Nadine M.; Hartmann, Sara; Hartig, Roland; Minguet, Susana; Schraven, Burkhart; Simeoni, Luca

In: Cells - Basel: MDPI, 2012, Bd. 11 (2022), 17, insges. 13 S.

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IL-13 determines specific IgE responses and SARS-CoV-2 immunity after mild COVID-19 and novel mRNA vaccination

Meltendorf, Stefan; Vogel, Katrin; Thurm, Christoph; Prätsch, Florian; Reinhold, Annegret; Färber, Jacqueline; Heuft, Hans-Gert; Kaasch, Achim; Hachenberg, Thomas; Weinzierl, Stefan; Schraven, Burkhart; Reinhold, Dirk; Brunner-Weinzierl, Monika; Lingel, Holger

In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft 12, S. 1972-1979

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Genetic knock-out of TNFR1 and TNFR2 in a JAK2-V617F polycythemia vera mouse model. Letter

Müller, Peter; Baldauf, Conny K.; Haage, Tobias Ronny; Charakopoulos, Emmanouil; Böttcher, Martin; Bhuria, Vikas; Mougiakakos, Dimitrios; Schraven, Burkhart; Fischer, Thomas

In: HemaSphere - [Philadelphia, Pennsylvania]: Wolters Kluwer Health, 2017, Bd. 6 (2022), 5, insges. 4 S.

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Thromboinflammation in myeloproliferative neoplasms (MPN) - a puzzle still to be solved

Bhuria, Vikas; Baldauf, Conny K.; Schraven, Burkhart; Fischer, Thomas

In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 6, insges. 21 S.

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T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation

Cammann, Clemens; Israel, Nicole; Frentzel, Sarah; Jeron, Andreas; Topfstedt, Eylin; Schüler, Thomas; Simeoni, Luca; Zenker, Martin; Fehling, Hans Joerg; Schraven, Burkhart; Bruder, Dunja; Seifert, Ulrike

In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 13 (2022), Artikel 958616, insges. 15 S.

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Y192 within the SH2 domain of Lck regulates TCR signaling downstream of PLC-γ1 and thymic selection

Kästle, Matthias; Merten, Camilla; Hartig, Roland; Plaza Sirvent, Carlos; Schmitz, Ingo; Bommhardt, Ursula; Schraven, Burkhart; Simeoni, Luca

In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 13, insges. 15 S.

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Regulation of T cell activation and T cell development via the conserved tyrosine 192 within the SH2 domain of the Src family kinase p56Lck

Kästle, Matthias; Schraven, Burkhart

In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Naturwissenschaften 2022, XV, 150 Seiten [Literaturverzeichnis: Seite 136-150]

Anämie-Prävalenz der älteren Bevölkerung in Sachsen-Anhalt

Mikuško, Martin; Bartsch, Rainer; Wolleschak, Denise; Wehde, Natalie; Lux, Anke; Kropf, Siegfried; Schraven, Burkhart; Mougiakakos, Dimitrios; Fischer, Thomas

In: Ärzteblatt Sachsen-Anhalt - offizielles Mitteilungsblatt der Ärztekammer Sachsen-Anhalt - Magdeburg: Ärztekammer Sachsen-Anhalt, Bd. 33 (2022), 6, S. 21-25

Peripheral mast cell-derived RANKL is a prerequisite for lymphocyte egress from distant lymph nodes

Katsoulis-Dimitriou, Konstantinos; Umer, Waqar; Haffner-Luntzer, Melanie; Edler, Hanna; Baumgart, Kathleen; Schraven, Burkhart; Fröbel, Julia; Ignatius, Anita; Dudeck, Jan; Dudeck, Anne

In: European journal of immunology - Weinheim: Wiley-VCH, 1971, Bd. 51 (2021), Suppl. 1, S. 35

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The activity and stability of p56Lck and TCR signaling do not depend on the co-chaperone Cdc37

Kowallik, Sarah; Kritikos, Andreas; Kästle, Matthias; Thurm, Christoph; Schraven, Burkhart; Reinhold, Dirk; Simeoni, Luca

In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 22 (2021), Heft 1, Artikel 126, insges. 12 S.

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The multiple roles of the cytosolic adapter proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -mediated signaling events

Dadwal, Nirdosh; Mix, Charlie; Reinhold, Annegret; Witte, Amelie; Freund, Christian; Schraven, Burkhart; Kliche, Stefanie

In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 12 (2021), insges. 14 S.

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Screening of FDA-approved drug library identifies adefovir dipivoxil as highly potent inhibitor of T cell proliferation

Voss, Linda; Guttek, Karina; Reddig, Annika; Reinhold, Annegret; Voss, Martin; Schraven, Burkhart; Reinhold, Dirk

In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 11 (2021), insges. 16 S.

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Enhanced susceptibility of ADAP-deficient mice to Listeria monocytogenes infection is associated with an altered phagocyte phenotype and function

Böning, Martha A. L.; Parzmair, Gerald P.; Jeron, Andreas; Düsedau, Henning Peter; Kershaw, Olivia; Xu, Baolin; Relja, Borna; Schlüter, Dirk; Dunay, Ildikò Rita; Reinhold, Annegret; Schraven, Burkhart; Bruder, Dunja

In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 12 (2021), Artikel 724855, insges. 20 S.

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Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells

Formaglio, Pauline; Alabdullah, Mohamad; Siokis, Anastasios; Handschuh, Juliane; Sauerland, Ina; Fu, Yan; Krone, Anna; Gintschel, Patricia; Stettin, Juliane; Heyde, Sandrina; Mohr, Juliane; Philipsen, Lars; Schröder, Anja; Robert, Philippe A.; Zhao, Gang; Khailaie, Sahamoddin; Dudeck, Anne; Bertrand, Jessica; Späth, Gerald F.; Kahlfuß, Sascha; Bousso, Philippe; Schraven, Burkhart; Hühn, Jochen; Binder, Sebastian; Meyer-Hermann, Michael; Müller, Andreas Johann

In: Immunity - [Cambridge, Mass.] : Cell Press, Bd. 54 (2021), Heft 12, S. 2724-2739.e10

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Cooperative interaction of Nck and Lck orchestrates optimal TCR signaling

Hartl, Frederike; Ngoenkam, Jatuporn; Beck-García, Esmeralda; Cerqueira, Liz; Wipa, Piyamaporn; Paensuwan, Pussadee; Suriyaphol, Prapat; Mishra, Pankaj; Schraven, Burkhart; Günther, Stefan; Pongcharoen, Sutatip; Schamel, Wolfgang; Minguet, Susana

In: Cells - Basel: MDPI, 2012, Bd. 10 (2021), 4, insges. 13 S.

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Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation

Dudeck, Jan; Kotrba, Johanna; Immler, Roland Thomas; Hoffmann, Aaron; Voss, Martin; Alexakē, Basileia-Ismēnē; Morton, Lorena; Jahn, Stephan René; Katsoulis-Dimitriou, Konstantinos; Winzer, Simon; Kollias, Georg; Fischer, Thomas; Nedospasov, Sergei A.; Dunay, Ildikò Rita; Chavakis, Triantafyllos; Müller, Andreas Johann; Schraven, Burkhart; Sperandio, Markus; Dudeck, Anne

In: Immunity - [Cambridge, Mass.]: Cell Press, Bd. 54 (2021), 3, S. 468-483.e5

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Pitavastatin is a highly potent inhibitor of T-cell proliferation

Voss, Linda; Guttek, Karina; Reddig, Annika; Reinhold, Annegret; Voss, Martin; Simeoni, Luca; Schraven, Burkhart; Reinhold, Dirk

In: Pharmaceuticals - Basel : MDPI, Bd. 14 (2021), Heft 8, Artikel 727, insges. 19 S.

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Zinc aspartate induces IL-16 secretion and apoptosis in human T cells

Reinhold, Dirk; Guttek, Karina; Reddig, Annika; Voss, Linda; Schubert, Claudia; Kahlfuß, Sascha; Grüngreiff, Kurt; Schraven, Burkhart; Reinhold, Annegret

In: Biomedicines - Basel : MDPI, Bd. 9 (2021), Heft 3, Artikel 246, insges. 11 S.

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Metabolic interdependency of Th2 cell-mediated type 2 immunity and the tumor microenvironment

Schreiber, Simon; Hammers, Christoph; Kaasch, Achim; Schraven, Burkhart; Dudeck, Anne; Kahlfuß, Sascha

In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 12 (2021), insges. 12 S.

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Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during Leishmania major skin infection

Kleinholz, Corinna L.; Riek-Burchardt, Monika; Seiß, Elena Anne; Amore, Jonas; Gintschel, Patricia; Philipsen, Lars; Bousso, Philippe; Relja, Borna; Schraven, Burkhart; Handschuh, Juliane; Mohr, Juliane; Müller, Andreas Johann

In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 11 (2021), insges. 12 S.

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ABC transporters in T cell-mediated physiological and pathological immune responses

Thurm, Christoph; Schraven, Burkhart; Kahlfuß, Sascha

In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 17, insges. 10 S.

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ADAP's intrinsically disordered region is an actin sponge regulating T cell motility

Dadwal, Nirdosh; Degen, Janine; Sticht, Jana; Hilal, Tarek; Wegner, Tatjana; Reichardt, Peter; Lyck, Ruth; Abadier, Michael; Hons, Miroslas; Mix, Charlie; Kuropka, Benno; Stephanowitz, Heike; Liu, Fan; Schraven, Burkhart; Wülfing, Christoph; Kliche, Stefanie; Freund, Christian

In: bioRxiv beta - Cold Spring Harbor: Cold Spring Harbor Laboratory, NY . - 2021, insges. 20 S.

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Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal

Baumann, Tobias; Dunkel, Andreas; Schmid, Christian; Schmitt, Sabine; Hiltensperger, Michael; Lohr, Kerstin; Laketa, Vibor; Donakonda, Sainitin; Ahting, Uwe; Lorenz-Depiereux, Bettina; Heil, Jan Erik; Schredelseker, Johann; Simeoni, Luca; Fecher, Caroline; Körber, Nina; Bauer, Tanja; Hüser, Norbert; Hartmann, Daniel; Laschinger, Melanie; Eyerich, Kilian; Eyerich, Stefanie; Anton, Martina; Streeter, Matthew; Wang, Tina; Schraven, Burkhart; Spiegel, David; Assaad, Farhah; Misgeld, Thomas; Zischka, Hans; Murray, Peter J.; Heine, Annkristin; Heikenwälder, Mathias; Korn, Thomas; Dawid, Corinna; Hofmann, Thomas F.; Knolle, Percy A.; Höchst, Bastian

In: Nature immunology - London: Springer Nature Limited, Bd. 21 (2020), 5, S. 555-566, insges. 12 S.

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Ratio and index of neurofilament light chain indicate its origin in GuillainBarré Syndrome

Körtvélyessy, Péter; Kuhle, Jens; Düzel, Emrah; Vielhaber, Stefan; Schmidt, Christian; Heinius, Annika; Leypoldt, Frank; Schraven, Burkhart; Reinhold, Dirk; Leppert, David; Goihl, Alexander

In: Annals of Clinical and Translational Neurology - Chichester [u.a.] : Wiley, Bd. 7 (2020), Heft 11, S. 2213-2220

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Tyrosine 192 within the SH2 domain of the Srcprotein tyrosine kinase p56Lck regulates Tcell activation independently of Lck/CD45 interactions

Kästle, Matthias; Merten, Camilla; Hartig, Roland; Kaehne, Thilo; LiaunardyJopeace, Ardiyanto; Woessner, Nadine M.; Schamel, Wolfgang; James, John; Minguet, Susana; Simeoni, Luca; Schraven, Burkhart

In: Cell communication and signaling - London: Biomed Central, 2003, Vol. 18.2020, Art.-Nr. 183, insgesamt 18 Seiten

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Serum and CSF cytokine levels mirror different neuroimmunological mechanisms in patients with LGI1 and Caspr2 encephalitis

Körtvélyessy, Péter; Goihl, Alexander; Guttek, Karina; Schraven, Burkhart; Prüß, Harald; Reinhold, Dirk

In: Cytokine - Oxford [u.a.] : Elsevier - Vol. 135.2020, 155226

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Kv1.3 potassium channels - promising therapeutic targets in hematological malignancies

Lowinus, Theresa; Bose, Tanima; Simeoni, Luca; Schraven, Burkhart; Bommhardt, Ursula

In: Journal of cellular signaling - Wilmington: Scientific Archives LLC, 2020, Bd. 1 (2020), 3, S. 79-86

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ADAP promotes degranulation and migration of NK cells primed during in vivo Listeria monocytogenes infection in mice

Böning, Martha A. L.; Trittel, Stephanie; Riese, Peggy; Ham, Marco Adrianus; Heyner, Maxi; Voss, Martin; Parzmair, Gerald P.; Klawonn, Frank; Jeron, Andreas; Guzmán, Carlos; Jänsch, Lothar; Schraven, Burkhart; Reinhold, Annegret; Bruder, Dunja

In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Vol. 10.2020, Art.-Nr. 3144, insgesamt 16 Seiten

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Inflammatory CD11c+ monocytes constitute a main reservoir for high proliferation and cell-to-cell transmission of Leishmania major

Heyde, Sandrina; Philipsen, Lars; Formaglio, Pauline; Fu, Yan; Baars, Iris; Höbbel, Guido; Kleinholz, Corinna L.; Seiß, Elena Anne; Stettin, Juliane; Gintschel, Patricia; Dudeck, Anne; Bousso, Philippe; Schraven, Burkhart; Müller, Andreas Johann

In: European journal of immunology: basic, clinical, translational - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 3, P0943, S. 1195

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Regulating microvesicle transport at the immunological synapse

Ham, Marco; Amsberg, Nicole; Reinking, Janne; Philipsen, Lars; Müller, Andreas Johann; Hühn, Jochen; Schraven, Burkhart; Jänsch, Lothar

In: European journal of immunology: basic, clinical, translational - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 1, P379, Seite 281

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Regulation of Lck activity via a highly conserved cysteine residue within the kinase domain

Kritikos, Andreas; Kowallik, Sarah; Schraven, Burkhart; Simeoni, Luca

In: European journal of immunology - Weinheim : Wiley-VCH - Bd. 49.2019, Suppl. 1, P231, Seite 194-195

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A highly conserved tyrosine residue within the SH2 domain of Lck regulates T-cell development and activation

Kästle, Matthias; Merten, Camilla; Simeoni, Luca; Schraven, Burkhart

In: European journal of immunology - Weinheim : Wiley-VCH - Bd. 49.2019, Suppl. 1, P208, Seite 182

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Cytokine release, degranulation and migratory capacity of NK cells depends on ADAP during Listeria monocytogenes infection of mice

Böning, Martha A. L.; Parzmair, Gerald P.; Jeron, Andreas; Riese, Peggy; Trittel, Stephanie; Heyner, Maxi; Voss, Martin; Jänsch, Lothar; Guzmán, Carlos; Schraven, Burkhart; Reinhold, Annegret; Bruder, Dunja

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Beyond TCR signaling - emerging functions of Lck in cancer and immunotherapy

Bommhardt, Ursula; Schraven, Burkhart; Simeoni, Luca

In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 14, Art.-Nr. 3500, insges. 18 S.

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Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling

Lowinus, Theresa; Heidel, Florian; Bose, Tanima; Nimmagadda, Subbaiah Chary; Schnöder, Tina; Cammann, Clemens; Schmitz, Ingo; Seifert, Ulrike; Fischer, Thomas; Schraven, Burkhart; Bommhardt, Ursula

In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 17.2019, Art.-Nr. 5, insges. 13 S.

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Immune cell-type specific ablation of adapter protein ADAP differentially modulates EAE

Rudolph, Jochen M.; Meinke, Clara; Voss, Martin; Guttek, Karina; Kliche, Stefanie; Reinhold, Dirk; Schraven, Burkhart; Reinhold, Annegret

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Characterization of mice with a platelet-specific deletion of the adapter molecule ADAP

Rudolph, Jochen M.; Guttek, Karina; Weitz, Gabriele; Meinke, Clara Antonia; Kliche, Stefanie; Reinhold, Dirk; Schraven, Burkhart; Reinhold, Annegret

In: Molecular and cellular biology - Washington, DC : Soc - Bd. 39.2019, 9, Art.-Nr. e00365-18, insges. 16 S.

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Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils

Seiß, Elena Anne; Krone, Anna; Formaglio, Pauline; Goldmann, Oliver; Engelmann, Susanne; Schraven, Burkhart; Medina, Eva; Müller, Andreas Johann

In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 9.2019, Art.-Nr. 5703, insges. 10 S.

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Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency

Dudeck, Jan; Froebel, Julia; Kotrba, Johanna; Lehmann, Christian H.K.; Dudziak, Diana; Speier, Stephan; Nedospasov, Sergei A.; Schraven, Burkhart; Dudeck, Anne

In: The journal of allergy and clinical immunology - Amsterdam [u.a.]: Elsevier, Bd. 143.2019, 5, S. 1849-1864.e4

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HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience

Raza, Syed Ahsan; Albrecht, Anne; Çalişkan, Gürsel; Müller, Bettina; Demiray, Yunus Emre; Ludewig, Susann; Meis, Susanne; Faber, Nicolai; Hartig, Roland; Schraven, Burkhart; Leßmann, Volkmar; Schwegler, Herbert; Stork, Oliver

In: 11th FENS Forum of Neuroscience: 7-11 July 2018, Berlin, Germany ; abstracts - FENS, 2018, 2018, Abstract 3915

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Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells

Mix, Charlie; Waldt, Natalie; Seifert, Anke; Demiray, Yunus Emre; Reichardt, Peter; Reinhold, Annegret; Freund, Christian; Müller, Andreas Johann; Schraven, Burkhart; Stork, Oliver; Kliche, Stefanie

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CD45 in human physiology and clinical medicine

Rheinländer, Andreas; Schraven, Burkhart; Bommhardt, Ursula

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Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells

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CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission

Heyde, Sandrina; Philipsen, Lars; Formaglio, Pauline; Fu, Yan; Baars, Iris; Höbbel, Guido; Kleinholz, Corinna L.; Seiß, Elena Anne; Stettin, Juliane; Gintschel, Patricia; Dudeck, Anne; Bousso, Philippe; Schraven, Burkhart; Müller, Andreas Johann

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JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation

Edelmann, Bärbel; Gupta, Nibedita; Schnöder, Tina; Oelschlegel, Anja Maria; Shahzad, Khurrum; Goldschmidt, Jürgen; Philipsen, Lars; Weinert, Sönke; Ghosh, Aniket; Saalfeld, Felix C.; Nimmagadda, Subbaiah Chary; Müller, Peter; Braun-Dullaeus, Rüdiger C.; Mohr, Juliane; Wolleschak, Denise; Kliche, Stefanie; Amthauer, Holger; Heidel, Florian; Schraven, Burkhart; Isermann, Berend; Müller, Andreas Johann; Fischer, Thomas

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Beware the intruder - real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo

Neumann, Jens; Henneberg, Sophie; Kenne, Susanne; Nolte, Niklas; Müller, Andreas Johann; Schraven, Burkhart; Görtler, Michael; Reymann, Klaus G.; Gunzer, Matthias; Riek-Burchardt, Monika

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De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

Philipsen, Lars; Reddycherla, Amarendra Varma; Hartig, Roland; Gumz, Janine; Kästle, Matthias; Kritikos, Andreas; Poltorak, Mateusz Pawel; Prokazov, Yury; Turbin, Evgeny; Weber, André; Zuschratter, Werner; Schraven, Burkhart; Simeoni, Luca; Müller, Andreas Johann

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A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity

Thurm, Christoph; Poltorak, Mateusz Pawel; Reimer, Elisa; Brinkmann, Melanie M.; Leichert, Lars I.; Schraven, Burkhart; Simeoni, Luca

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Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells

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HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience

Raza, Ahsan Syed; Albrecht, Anne; Çalişkan, Gürsel; Müller, Bettina; Demiray, Yunus Emre; Ludewig, Susann; Meis, Susanne; Faber, Nicolai; Hartig, Roland; Schraven, Burkhart; Leßmann, Volkmar; Schwegler, Herbert; Stork, Oliver

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JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1

Gupta, Nibedita; Edelmann, Bärbel; Schnöder, Tina; Saalfeld, Felix C.; Wolleschak, Denise; Kliche, Stefanie; Schraven, Burkhart; Heidel, Florian; Fischer, Thomas

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D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes

Witte, Amelie; Meineke, Bernhard; Sticht, Jana; Philipsen, Lars; Kuropka, Benno; Müller, Andreas Johann; Freund, Christian; Schraven, Burkhart; Kliche, Stefanie

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LPS stimulation induces ROS formation, apoptosis, DNA damage and oxidation of cysteine residues in FLT3-ITD positive cell lines resulting in FLT3-tyrosine kinase inhibitor resistance

Müller, Christian; Schnöder, Tina; Simeoni, Luca; Heidel, Florian; Thurm, Christoph; Schraven, Burkhart; Fischer, Thomas

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Reactive oxygen species (ROS) modulates sensitivity to FLT3-tyrosine kinase inhibitors in murine and human FLT3-ITD positive AML cell lines

Müller, Christian; Simeoni, Luca; Heidel, Florian; Schraven, Burkhart; Fischer, Thomas

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Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling

Kuropka, Benno; Schraven, Burkhart; Kliche, Stefanie; Krause, Eberhard; Freund, Christian

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ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens

Parzmair, Gerald P.; Gereke, Marcus; Haberkorn, Oxana; Annemann, Michaela; Podlasly, Lisa; Kliche, Stefanie; Reinhold, Annegret; Schraven, Burkhart; Bruder, Dunja

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Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness

Lowinus, Theresa; Bose, Tanima; Busse, Stefan Gregor; Busse, Mandy; Reinhold, Dirk; Schraven, Burkhart; Bommhardt, Ursula H. H.

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Normal development and function of T cells in proline rich 7 (Prr7) deficient mice

Hrdinka, Matous; Sudan, Kritika; Just, Sissy; Drobek, Ales; Stepanek, Ondrej; Schlüter, Dirk; Reinhold, Dirk; Jordan, Bryen A.; Gintschel, Patricia; Schraven, Burkhart; Kreutz, Michael R.

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Early changes in the metabolic profile of activated CD8+ T cells

Cammann, Clemens; Rath, Alexander; Reichl, Udo; Lingel, Holger; Brunner-Weinzierl, Monika; Simeoni, Luca; Schraven, Burkhart; Lindquist, Jonathan A.

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Atypical I[kappa]B proteins in immune cell differentiation and function

Annemann, Michaela; Plaza-Sirvent, Carlos; Schuster, Marc; Katsoulis-Dimitriou, Konstantinos; Kliche, Stefanie; Schraven, Burkhart; Schmitz, Ingo

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Catchup - a mouse model for imaging-based tracking and modulation of neutrophil granulocytes

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Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function

Perner, Florian; Schnöder, Tina; Ranjan, Satish; Wolleschak, Denise; Ebert, Carolin; Pils, Marina C.; Frey, Stephanie; Polanetzki, Anja; Fahldieck, Corinna; Schönborn, Uta; Schraven, Burkhart; Isermann, Berend; Fischer, Thomas; Heidel, Florian

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Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64+ cells

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Analysis of phosphorylation-dependent protein interactions of adhesion and degranulation promoting adaptor protein (ADAP) reveals novel interaction partners required for chemokine-directed T cell migration

Kuropka, Benno; Witte, Amelie; Sticht, Jana; Waldt, Natalie; Majkut, Paul; Hackenberger, Christian; Schraven, Burkhart; Krause, Eberhard; Kliche, Stefanie; Freund, Christian

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T cells and reactive oxygen species

Belikov, Aleksey V.; Schraven, Burkhart; Simeoni, Luca

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MiR-20a inhibits TCR-mediated signaling and cytokine production in human naïve CD4+ T cells

Reddycherla, Amarendra Varma; Meinert, Ines; Reinhold, Annegret; Reinhold, Dirk; Schraven, Burkhart; Simeoni, Luca

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Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

Neumann, Jens; Riek-Burchardt, Monika; Herz, Josephine; Döppner, Thorsten Roland; König, Rebecca; Hütten, Heiko; Etemire, Eloho; Männ, Linda; Klingberg, Anika; Fischer, Thomas; Görtler, Michael; Heinze, Hans-Jochen; Reichardt, Peter; Schraven, Burkhart; Hermann, Dirk Matthias; Reymann, Klaus G.; Gunzer, Matthias

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The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis

Engelmann, Swen; Togni, Mauro; Kliche, Stefanie; Reinhold, Dirk; Schraven, Burkhart; Reinhold, Annegret

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TCR-triggered extracellular superoxide production is not required for T-cell activation

Belikov, Aleksey V.; Schraven, Burkhart; Simeoni, Luca

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Immunosuppression by N-Methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells

Kahlfuß, Sascha; Simma, Narasimhulu; Mankiewicz, Judith; Bose, Tanima; Lowinus, Theresa; Klein-Heßling, Stefan; Sprengel, Rolf; Schraven, Burkhart; Heine, Martin; Bommhardt, Ursula

In: Molecular and cellular biology - Washington, DC: Soc., Bd. 34 (2014), 5, S. 820-831, insges. 12 S.

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Clinically relevant doses of FLT3-kinase inhibitors Quizartinib and Midostaurin do not impair T-cell reactivity and function

Wolleschak, Denise; Mack, Thomas S.; Perner, Florian; Frey, Stephanie; Schnöder, Tina; Wagner, Marie-Christine; Höding, Christine; Pils, Marina C.; Parkner, Andreas; Kliche, Stefanie; Schraven, Burkhart; Hebel, Katrin; Brunner-Weinzierl, Monika; Ranjan, Satish; Isermann, Berend; Lipka, Daniel; Fischer, Thomas; Heidel, Florian

In: Haematologica - Pavia : Ferrata Storti Foundation - Bd. 99.2014, 6, S. e90-e93

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Hippocampus-dependent learning in SKAP-HOM deficient mice

Fiedler, Anna; Grecksch, Gisela; Reinhold, Annegret; Schraven, Burkhart; Becker, Axel

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Tetanus toxoid-pulsed monocyte vaccination for augmentation of collateral vessel growth

Herold, Jörg; Francke, Alexander; Weinert, Soenke; Schmeisser, Alexander; Hebel, Katrin; Schraven, Burkhart; Roehl, Friedich-Wilhelm; Strasser, Ruth H.; Braun-Dullaeus, Ruediger C.

In: Journal of the American Heart Association - New York, NY : Association - Bd. 3.2014, 2, Art.-Nr. e000611, insges. 12 S.

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Sos1 regulates sustained TCR-mediated Erk activation

Poltorak, Mateusz; Meinert, Ines; Stone, James C.; Schraven, Burkhart; Simeoni, Luca

In: European journal of immunology. - Weinheim : Wiley-VCH, Bd. 44.2014, 5, S. 1535-1540

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Negative interactions and feedback regulations are required for transient cellular response

Mobashir, Mohammad; Madhusudhan, Thati; Isermann, Berend; Beyer, Tilo; Schraven, Burkhart

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Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation

Harder, Thomas; Guttek, Karina; Philipsen, Lars; Simeoni, Luca; Schraven, Burkhart; Reinhold, Dirk

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NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells

Simma, Narasimhulu; Bose, Tanima; Kahlfuß, Sascha; Mankiewicz, Judith; Lowinus, Theresa; Lühder, Fred; Schüler, Thomas; Schraven, Burkhart; Heine, Martin; Bommhardt, Ursula

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PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells

Smida, Michal; Cammann, Clemens; Gurbiel, Slavyana; Kerstin, Nadja; Lingel, Holger; Lindquist, Sabine; Simeoni, Luca; Brunner-Weinzierl, Monika; Suchanek, Miloslav; Schraven, Burkhart; Lindquist, Jonathan A.

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Discrete, qualitative models of interaction networks

Ballerstein, Kathrin; Haus, Utz-Uwe; Lindquist, Jonathan Axel; Beyer, Tilo; Schraven, Burkhart; Weismantel, Robert

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TCR activation kinetics and feedback regulation in primary human T cells

Poltorak, Mateusz; Arndt, Börge; Kowtharapu, Bhavani Shankar; Reddycherla, Amarendra V.; Witte, Vanessa Alexandra; Lindquist, Jonathan A.; Schraven, Burkhart; Simeoni, Luca

In: Cell communication and signaling - London: Biomed Central, Bd. 11.2013, Art.-Nr. 4, insges. 22 S.

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Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX

Arndt, Börge; Kalinski, Thomas; Reinhold, Dirk; Thielitz, Anja; Roessner, Albert; Schraven, Burkhart; Simeoni, Luca

In: Journal of leukocyte biology. - Bethesda, Md : FASEB, Bd. 93.2013, 3, S. 353-362

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Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters

Philipsen, Lars; Engels, Thomas; Schilling, Kerstin; Gurbiel, Slavyana; Fischer, Klaus-Dieter; Tedford, Kerry; Schraven, Burkhart; Gunzer, Matthias; Reichardt, Peter

In: Molecular & cellular proteomics - Bethesda, Md.: The American Society for Biochemistry and Molecular Biology, Bd. 12 (2013), 9, S. 2551-2567

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T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice

Engelmann, Swen; Togni, Mauro; Reinhold, Dirk; Thielitz, Anja; Reichardt, Peter; Kliche, Stefanie; Schraven, Burkhart; Reinhold, Annegret

In: The journal of immunology - Bethesda, Md: Soc, Bd. 191 (2013), 10, S. 4950-4959

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Cross-talk between the signalling pathways of the receptor for interleukin 2 and the T-cell antigen in human T-blasts

Hristov, Kroum; Lindquist, Jonathan; Schraven, Burkhart

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T cell activation results in conformational changes in the Src family kinase Lck to induce its activation

Stirnweiss, Anja; Hartig, Roland; Gieseler, Steffi; Lindquist, Jonathan A.; Reichardt, Peter; Philipsen, Lars; Simeoni, Luca; Poltorak, Mateusz; Merten, Camilla; Zuschratter, Werner; Prokazov, Yury; Paster, Wolfgang; Stockinger, Hannes; Harder, Thomas; Gunzer, Matthias; Schraven, Burkhart

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Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation

Arndt, Börge; Poltorak, Mateusz; Kowtharapu, Bhavani Shankar; Reichardt, Peter; Philipsen, Lars; Lindquist, Jonathan A.; Schraven, Burkhart; Simeoni, Luca

In: Journal of immunological methods: JIM - Amsterdam [u.a.]: Elsevier, Bd. 387 (2013), 1/2, S. 276-283

Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.

Arndt, Boerge; Poltorak, Mateusz; Kowtharapu, Bhavani S; Reichardt, Peter; Phillipsen, Lars; Lindquist, Jonathan A; Schraven, Burkhart; Simeoni, Luca

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SKAP2/SCAP2 (Src kinase-associated phosphoprotein 2)

Reinhold, Annegret; Schraven, Burkhart L.

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TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.

Warnecke, Nicole; Poltorak, Mateusz; Kowtharapu, Bhavani S; Arndt, Boerge; Stone, James C; Schraven, Burkhart; Simeoni, Luca

In: EMBO reports, Vol. 13, ISSN 1469-3178, , 10.1038/embor.2012.17

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An inhibitor study of interleukin 2 receptor (IL2R) signalling mechanisms in human T-lymphoblasts

Hristov, Kroum; Lindquist, Jonathan; Schraven, Burkhart

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CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules

Kliche, Stefanie; Worbs, Tim; Wang, Xiaoqian; Degen, Janine; Patzak, Irene Maria; Meineke, Bernhard; Togni, Mauro; Moser, Markus; Reinhold, Annegret; Kiefer, Friedemann; Freund, Christian; Förster, Reinhold; Schraven, Burkhart

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Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function

Pierau, Mandy; Na, Shin-Young; Simma, Narasimhulu; Lowinus, Theresa; Marx, Alexander; Schraven, Burkhart; Bommhardt, Ursula H.

In: European journal of immunology - Weinheim: Wiley, Bd. 42 (2012), 12, S. 3381-3393

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The adapter protein ADAP is required for selected dendritic cell functions

Togni, Mauro; Engelmann, Swen; Reinhold, Dirk; Schraven, Burkhart; Reinhold, Annegret

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Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

Linka, René M.; Risse, S. L.; Bienemann, K.; Werner, Markus; Linka, Yvonne; Krux, Frank; Synaeve, Cindy; Deenen, René; Ginzel, Sebastian; Dvorsky, Radovan; Gombert, Michael; Halenius, Anne; Hartig, Roland; Helminen, Merja; Fischer, Alain; Stepensky, Polina; Vettenranta, Kim; Köhrer, Karl; Ahmadian, M. Reza; Laws, Hans-Jürgen; Fleckenstein, Bernhard; Jumaa, Hassan; Latour, Sylvain; Schraven, Burkhart; Borkhardt, Arndt

In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 26.2012, 5, S. 963-971

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TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells

Warnecke, Nicole; Poltorak, Mateusz; Kowtharapu, Bhavani Shankar; Arndt, Börge; Stone, James C.; Schraven, Burkhart; Simeoni, Luca

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Re-stimulation of T-cell antigen receptor and regulation of the tyrosine phosphorylation in peripheral T-cells

Hristov, Kroum; Lindquist, Jonathan; Schraven, Burkhart

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Emerging roles of ADAP, SKAP55, and SKAP-HOM for integrin and NF-[kappa]B signaling in T cells

Witte, Amelie; Degen, Janine; Baumgart, Kathleen; Waldt, Natalie; Kuropka, Benno; Freund, Christian; Schraven, Burkhart; Kliche, Stefanie

In: Journal of clinical & cellular immunology - Sunnyvale, Calif.: OMICS Publishing Group, Bd. 3.2012, Nr. S12, Artikel-Nr.002, insges. 8 S.

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Simulated Evolution of Signal Transduction Networks

Mobashir, Mohammad; Schraven, Burkhart; Beyer, Tilo

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First insight into the kinome of human regulatory T cells

König, Sebastian; Probst-Kepper, Michael; Reinl, Tobias; Jeron, Andreas; Hühn, Jochen; Schraven, Burkhart; Jänsch, Lothar

In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 7.2012, 7, Art.-Nr. e40896, insges. 12 S.

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Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates Src kinase activity in brain maturation

Lindquist, Sabine; Karitkina, Diana; Langnäse, Kristina; Posevitz-Fejfár, Anita; Schraven, Burkhart; Xavier, Ramnik; Seed, Brian; Lindquist, Jonathan A.

In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 6.2011, 9, Art.-Nr. e23978 insges. 14 S.

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Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo

Hasenberg, Mike; Köhler, Anja; Bonifatius, Susanne; Borucki, Katrin; Riek-Burchardt, Monika; Achilles, Julia; Männ, Linda; Baumgart, Kathleen; Schraven, Burkhart; Gunzer, Matthias

In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 6, 2011, 2, Art. e17314, insges. 11 S.

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Integrating signals from the T-cell receptor and the interleukin-2 receptor

Beyer, Tilo; Busse, Mandy; Hristov, Kroum; Gurbiel, Slavyana; Smida, Michal; Haus, Utz-Uwe; Ballerstein, Kathrin; Pfeuffer, Frank; Weismantel, Robert; Schraven, Burkhart; Lindquist, Jonathan A.

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Protocol optimization for DOK2 immunoprecipitation from murine splenic and thymic T-cell preparations

Hristov, Kroum; Lindquist, Jonathan A.; Schraven, Burkhart

In: Dokladi na Bălgarskata Akademija na Naukite. - Sofija : Akademija, Bd. 64.2011, 7, S. 979-986

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G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands

Köhler, Anja; Filippo, Katia; Hasenberg, Mike; Brandt, Cindy; Nye, Emma; Hosking, Martin P.; Lane, Thomas E.; Männ, Linda; Ransohoff, Richard M.; Hauser, Anja E.; Winter, Oliver; Schraven, Burkhart; Geiger, Hartmut; Hogg, Nancy; Gunzer, Matthias

In: Blood: the journal of hematology / American Society of Hematology. William Dameshek, founding ed. - Washington, DC: American Society of Hematology, Bd. 117 (2011), 16, S. 4349-4357

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The SLP-76 Src homology 2 domain is required for T cell development and activation

Burns, Jeremy C.; Corbo, Evann; Degen, Janine; Gohil, Mercy; Anterasian, Christine; Schraven, Burkhart; Koretzky, Gary A.; Kliche, Stefanie; Jordan, Martha S.

In: The journal of immunology. - Bethesda, Md : American Assoc. of Immunologists, Bd. 187.2011, 9, S. 4459-4466

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The transmembrane adaptor protein SIT inhibits TCR-mediated signaling

Arndt, Börge; Krieger, Tina; Kalinski, Thomas; Thielitz, Anja; Reinhold, Dirk; Roessner, Albert; Schraven, Burkhart; Simeoni, Luca

In: PLoS one. - Lawrence, Kan : PLoS, Bd. 6.2011, 9, insges. 7 S.

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Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells

Sylvester, Marc; Kliche, Stefanie; Lange, Sabine; Geithner, Sabine; Klemm, Clementine; Schlosser, Andreas; Großmann, Arndt; Stelzl, Ulrich; Schraven, Burkhart; Krause, Eberhard; Freund, Christian

In: Public Library of Science : PLoS one . - Lawrence, Kan. : PLoS, Bd. 5.2010, 7, insges. 11 S.; Abstract

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Stoichiometry and intracellular fate of TRIM-containing TCR complexes

Swamy, Mahima; Siegers, Gabrielle M; Fiala, Gina J; Molnar, Eszter; Dopfer, Elaine P; Fisch, Paul; Schraven, Burkhart; Schamel, Wolfgang W. A.

In: Cell communication and signaling . - London : Biomed Central, Bd. 8.2010, insges. 10 S.; Abstract

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Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells

Rieke, Cornelia; Kähne, Thilo; Schweitzer, Katrin; Schraven, Burkhart; Wienands, Jürgen; Engelke, Michael; Naumann, Michael

In: Cellular signalling - Amsterdam: Elsevier, Bd. 22 (2010), 3, S. 395-403

Exploring the immune system - systems biology research networks in quest for new therapy options

Höfer, Thomas; Lindquist, Jonathan; Schraven, Burkhart; Schamel, Wolfgang

In: Systembiologie.de - Heidelberg : Dt. Krebsforschungszentrum, Abt. Theoret. Bioinformatik . - 2010, Heft 1, S. 51-55

Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells

Horn, Jessica; Wang, Xiaoqian; Reichardt, Peter; Stradal, Theresia; Warnecke, Nicole; Simeoni, Luca; Gunzer, Matthias; Yablonski, Deborah; Schraven, Burkhart; Kliche, Stefanie

In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 183.2009, 9, S. 5756-5767

Systematic amino acid substitutions improved efficiency of GD2-peptide mimotope vaccination against neuroblastoma

Bleeke, Matthias; Fest, Stefan; Hübener, Nicole; Landgraf, Christiane; Schraven, Burkhart; Gaedicke, Gerhard; Volkmer, Rudolf; Lode, Holger N.

In: The European journal of cancer: EJC ; the official journal of EORTC, European Organization for Research and Treatment of Cancer, ESO, European School of Oncology, EACR, European Association for Cancer Research, FECS, Federation of European Cancer Societies - Amsterdam [u.a.]: Elsevier, 1965, Bd. 45.2009, 16, S. 2915-2921

Mechanisms of opioid-mediated inhibition of human T cell receptor signaling

Börner, Christine; Warnick, Beate; Smida, Michal; Hartig, Roland; Lindquist, Jonathan; Schraven, Burkhart; Höllt, Volker; Kraus, Jürgen

In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 2, S. 882-889

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Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation

Pierau, Mandy; Engelmann, Swen; Reinhold, Dirk; Lapp, Thabo; Schraven, Burkhart; Bommhardt, Ursula

In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 10, S. 6124-6134

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Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo

Reinhold, Annegret; Reimann, Sibylle; Reinhold, Dirk; Schraven, Burkhart; Togni, Mauro

In: Journal of leukocyte biology . - Bethesda, Md. : FASEB, Bd. 86.2009, 1, S. 61-71

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Cannabinoid receptor type 1 and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling

Börner, Christine; Smida, Michal; Höllt, Volker; Schraven, Burkhart; Kraus, Jürgen

In: The journal of biological chemistry . - Bethesda, Md. : ASBMB, Bd. 284.2009, 51, S. 35450-35460

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Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling

Linnemann, Carsten; Schildberg, Frank A.; Schurich, Anna; Diehl, Linda; Hegenbarth, Silke I.; Endl, Elmar; Lacher, Svenja K.; Müller, Christa E.; Frey, Jürgen; Simeoni, Luca; Schraven, Burkhart; Wohlleber, Dirk; Knolle, Percy A.

In: Immunology - Oxford [u.a.]: Wiley-Blackwell, 1958, Bd. 128.2009, 1,Pt.2, S. e728-e737

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Sparking signals - kinases as molecular signaltransducers and pharmacological drug targets in inflammation

Baier, Gottfried; Schraven, Burkhart

In: Heidelberg [u.a.]: Springer, 2008, XIV, 185 S., Ill., graph. Darst., 22 cm - (Ernst Schering Foundation symposium proceedings; 2007,3)Kongress: Symposium. Ernst Schering Foundation (Potsdam : 2007.06.20-22)

A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration

Posevitz-Fejfár, Anita; Smída, Michal; Kliche, Stefanie; Hartig, Roland; Schraven, Burkhart; Lindquist, Jonathan

In: European journal of immunology . - Weinheim : Wiley VCH, Bd. 38.2008, 1, S. 250-259

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Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells

Wang, Xiaoqian; Simeoni, Luca; Lindquist, Jonathan A.; Saez-Rodriguez, Julio; Ambach, Andreas; Gilles, Ernst D.; Kliche, Stefanie; Schraven, Burkhart

In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 180.2008, 10, S. 6703-6712

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TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells

Bekeredjian-Ding, Isabelle; Doster, Anne; Schiller, Martin; Heyder, Petra; Lorenz, Hanns-Martin; Schraven, Burkhart; Bommhardt, Ursula; Heeg, Klaus

In: The journal of immunology - Rockville, Md.: American Association of Immunologists, Bd. 181 (2008), 12, S. 8267-8277

CD28 superagonists: what makes the difference in humans?

Schraven, Burkhart; Kalinke, Ulrich

In: Immunity . - Cambridge, Mass. : Cell Press, Bd. 28.2008, 5, S. 591-595

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The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1

Veracini, Laurence; Simon, Valérie; Richard, Véronique; Schraven, Burkhart; Horejsi, Vaclav; Roche, Serge; Benistant, Christine

In: The journal of cell biology . - New York, NY : Rockefeller Univ. Press, Bd. 182.2008, 3, S. 603-614

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Regulation of T cell homeostasis by the transmembrane adaptor protein SIT

Posevitz, Vilmos; Arndt, Börge; Krieger, Tina; Warnecke, Nicole; Schraven, Burkhart; Simeoni, Luca

In: The journal of immunology : official journal of the American Association of Immunologists. - Bethesda, Md : American Assoc. of Immunologists, Bd. 180.2008, 3, S. 1634-1642

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Signaling signatures and functional properties of antihuman CD28 superagonistic antibodies

Waibler, Zoe; Sender, Linda Y.; Merten, Camilla; Hartig, Roland; Kliche, Stefanie; Gunzer, Matthias; Reichardt, Peter; Kalinke, Ulrich; Schraven, Burkhart

In: PLoS one . - Lawrence, Kan. : PLoS, Bd. 3.2008, 3, insges. 13 S.; Abstract

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SIT and TRIM determine T cell fate in the thymus

Kölsch, Uwe; Schraven, Burkhart; Simeoni, Luca

In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 181.2008, 9, S. 5930-5939

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T-cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional [mu]-opioid receptors

Börner, Christine; Kraus, Jürgen; Bedini, Andrea; Schraven, Burkhart; Höllt, Volker

In: Molecular pharmacology . - Bethesda, Md. : American Society for Pharmacology and Experimental Therapeutics, ISSN 0026-895x, Bd. 74.2008, 2, S. 496-504

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Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts

Tauzin, Sebastien; Ding, Heidrun; Khatib, Karim; Ahmad, Ishtiaq; Burdevet, Dimitri; Echten-Deckert, Gerhild van; Lindquist, Jonathan; Schraven, Burkhart; Din, Nasir-ud-; Borisch, Bettina; Hoessli, Daniel C.

In: Blood . - Washington, DC : American Society of Hematology, Bd. 111.2008, 4, S. 2310-2320

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Systems biology of T cell activation

Lindquist, Jonathan; Schraven, Burkhart

In: Sparking signals . - Berlin [u.a.] : Springer, ISBN 978-3-540-73500-7, S. 43-61

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Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins

Simeoni, Luca; Lindquist, Jonathan A.; Smida, Michal; Witte, Vanessa Alexandra; Arndt, Börge; Schraven, Burkhart

In: Inhibition of immune cell function / Max D. Cooper guest ed. - Oxford: Blackwell Munksgaard, 2008; Cooper, Max D., Bd. 224 (2008), S. 215-228

Immunoreceptors & integrins

Schraven, Burkhart

In: Munksgaard: Blackwell, 2007, 264 S., Ill., graph. Darst. - (Immunological reviews; 218)

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Immunoreceptors & integrins

Schraven, Burkhart

In: Munksgaard: Blackwell, 2007, 264 S. - (Immunological reviews; 218)

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In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction

Jordan, Martha S.; Maltzman, Jonathan S.; Kliche, Stefanie; Shabason, Jacob; Smith, Jennifer E.; Obstfeld, Amrom; Schraven, Burkhart; Koretzky, Gary A.

In: European journal of immunology - Weinheim: Wiley, Bd. 37 (2007), 10, S. 2961-2972

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Fyn regulates the duration of TCR engagement needed for commitment to effector function

Filby, Andrew; Seddon, Benedict; Kleczkowska, Joanna; Salmond, Robert; Tomlinson, Peter; Smida, Michal; Lindquist, Jonathan A.; Schraven, Burkhart; Zamoyska, Rose

In: The journal of immunology - Rockville, Md. : American Association of Immunologists, Bd. 179 (2007), Heft 7, S. 4635-4644

Impact of HMG-CoA reductase inhibition on brain pathology

Zipp, Frauke; Waiczies, Sonia; Aktaş, Orhan; Neuhaus, Oliver; Hemmer, Bernhard; Schraven, Burkhart; Nitsch, Robert; Hartung, Hans-Peter

In: Trends in pharmacological sciences - Amsterdam : Cell Press, Bd. 28 (2007), Heft 7, S. 342-349

RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation

Ménasché, Gaël; Kliche, Stefanie; Chen, Emily J. H.; Stradal, Theresia E. B.; Schraven, Burkhart; Koretzky, Gary A.

In: Molecular and cellular biology - Washington, DC : American Society for Microbiology, Bd. 27 (2007), Heft 11, S. 4070-4081

Deletion of the LIME adaptor protein minimally affects T and B cell development and function

Grégoire, Claude; Simova, Sarka; Wang, Ying; Sansoni, Amandine; Richelme, Sylvie; Schmidt-Giese, Anja; Simeoni, Luca; Angelisova, Pavla; Reinhold, Dirk; Schraven, Burkhart; Horejsi, Vaclav; Malissen, Bernard; Malissen, Marie

In: European journal of immunology - Weinheim: Wiley, Bd. 37 (2007), 11, S. 3259-3269

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Fyn regulates the duration of TCR engagement needed for commitment to effector function

Filby, Andrew; Seddon, Benedict; Kleczkowska, Joanna; Salmond, Robert; Tomlinson, Peter; Smida, Michal; Lindquist, Jonathan A.; Schraven, Burkhart; Zamoyska, Rose

In: The journal of immunology - Rockville, Md.: American Association of Immunologists, Bd. 179 (2007), 7, S. 4635-4644

Impact of HMG-CoA reductase inhibition on brain pathology

Zipp, Frauke; Waiczies, Sonia; Aktaş, Orhan; Neuhaus, Oliver; Hemmer, Bernhard; Schraven, Burkhart; Nitsch, Robert; Hartung, Hans-Peter

In: Trends in pharmacological sciences: TIPS ; including toxicological sciences - Amsterdam: Cell Press, Bd. 28 (2007), 7, S. 342-349

A logical model provides insights into T cell receptor signaling

Sáez Rodríguez, Julio; Simeoni, Luca; Lindquist, Jonathan A.; Hemenway, Rebecca; Bommhardt, Ursula; Arndt, Börge; Haus, Utz-Uwe; Weismantel, Robert; Gilles, Ernst D.; Klamt, Steffen; Schraven, Burkhart

In: PLoS Computational Biology - San Francisco, Calif: Public Library of Science, Bd. 3(2007), 8, insges. 11 S.

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PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes

Davidson, Dominique; Schraven, Burkhart; Veillette, André

In: Molecular and cellular biology: MCB / American Society for Microbiology - Washington, DC: American Society for Microbiology, Bd. 27 (2007), 5, S. 1960-1973

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A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains - blocking Ras activation

Smida, Michal; Posevitz-Fejfár, Anita; Horejsi, Vaclav; Schraven, Burkhart; Lindquist, Jonathan A.

In: Blood: the journal of hematology / American Society of Hematology. William Dameshek, founding ed. - Washington, DC: American Society of Hematology, Bd. 110 (2007), 2, S. 596-605

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RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation

Ménasché, Gaël; Kliche, Stefanie; Chen, Emily J. H.; Stradal, Theresia; Schraven, Burkhart; Koretzky, Gary

In: Molecular and cellular biology: MCB / American Society for Microbiology - Washington, DC: American Society for Microbiology, Bd. 27 (2007), 11, S. 4070-4081

TGF-[beta]1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26

Preller, Vera; Gerber, Annegret; Wrenger, Sabine; Togni, Mauro; Marguet, Didier; Tadje, Janine; Lendeckel, Uwe; Röcken, Christoph; Faust, Jürgen; Neubert, Klaus; Schraven, Burkhart; Martin, Roland; Ansorge, Siegfried; Brocke, Stefan; Reinhold, Dirk

In: The journal of immunology - Rockville, Md.: American Association of Immunologists, Bd. 178 (2007), 7, S. 4632-4640

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ADAP is required for normal [alpha]IIb[beta]3 activation by VWF/GP Ib-IX-V and other agonists

Kasirer-Friede, Ana; Moran, Barry; Nagrampa-Orje, Jennifer; Swanson, Ken; Ruggeri, Zaverio M.; Schraven, Burkhart; Neel, Benjamin G.; Koretzky, Gary; Shattil, Sanford J.

In: Blood: the journal of hematology / American Society of Hematology. William Dameshek, founding ed. - Washington, DC: American Society of Hematology, Bd. 109 (2007), 3, S. 1018-1025

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Immunoreceptors and integrins

Schraven, Burkhart; Reth, Michael

In: Immunoreceptors & integrins - Munksgaard: Blackwell, 2007; Schraven, Burkhart, Bd. 218 (2007), S. 5-8

Publikationslink

Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap 1 effector molecules

Ménasché, Gaël; Kliche, Stefanie; Bezman, Natalie; Schraven, Burkhart

In: Immunoreceptors & integrins - Munksgaard: Blackwell, 2007; Schraven, Burkhart, Bd. 218 (2007), S. 82-91

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Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap 1 effector molecules

Ménasché, Gaël; Kliche, Stefanie; Bezman, Natalie; Schraven, Burkhart

In: Immunoreceptors & integrins - Munksgaard : Blackwell , 2007 ; Schraven, Burkhart, Bd. 218 (2007), S. 82-91

Cell communication in nervous and immune system

Gundelfinger, Eckart D.; Seidenbecher, Constanze I.; Schraven, Burkhart

In: Heidelberg: Springer, 2006, XIV, 313 S. - (Results and problems in cell differentiation; 43), ISBN: 3-540-36828-0, 978-3-540-36828-1 EUR 160.45 (freier Pr.), sfr 254.00 (freier Pr.)

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Cell communication in nervous and immune system

Gundelfinger, Eckart D.; Seidenbecher, Constanze; Schraven, Burkhart

In: Heidelberg: Springer, 2006, XIV, 313 S., Ill., graph. Darst., 24 cm - (Results and problems in cell differentiation; 43)

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Normal T-cell development and immune functions in TRIM-deficient mice

Kölsch, Uwe; Arndt, Börge; Reinhold, Dirk; Lindquist, Jonathan A.; Jüling, Nicole; Kliche, Stefanie; Pfeffer, Klaus; Bruyns, Eddy; Schraven, Burkhart; Simeoni, Luca

In: Molecular and cellular biology - Washington, DC : American Society for Microbiology, Bd. 26 (2006), Heft 9, S. 3639-3648

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The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1

Kliche, Stefanie; Breitling, Dennis; Togni, Mauro; Pusch, Rico; Heuer, Katja; Wang, Xiaoqian; Freund, Christian; Kasirer-Friede, Ana; Menasche, Gael; Koretzky, Gary A.; Schraven, Burkhart

In: Molecular and cellular biology: MCB / American Society for Microbiology - Washington, DC: American Society for Microbiology, Bd. 26 (2006), 19, S. 7130-7144

Normal T-cell development and immune functions in TRIM-deficient mice

Kölsch, Uwe; Arndt, Börge; Reinhold, Dirk; Lindquist, Jonathan A.; Jüling, Nicole; Kliche, Stefanie; Pfeffer, Klaus; Bruyns, Eddy; Schraven, Burkhart; Simeoni, Luca

In: Molecular and cellular biology: MCB / American Society for Microbiology - Washington, DC: American Society for Microbiology, Bd. 26 (2006), Heft 9, S. 3639-3648

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Fatal neonatal-onset mitochondrial respiratory chain disease with T cell immunodeficiency

Reichenbach, Janine; Schubert, Ralf; Horvàth, Rita; Petersen, Jens; Fütterer, Nancy; Malle, Elisabeth; Stumpf, Andreas; Gebhardt, Boris R.; Koehl, Ulrike; Schraven, Burkhart; Zielen, Stefan

In: Pediatric research - New York : Springer Nature, Bd. 60 (2006), Heft 3, S. 321-326

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Lipid-binding hSH3 domains in immune cell adapter proteins

Heuer, Katja; Sylvester, Marc; Kliche, Stefanie; Pusch, Rico; Thiemke, Katharina; Schraven, Burkhart; Freund, Christian

In: Journal of molecular biology / ed.-in-chief J. C. Kendrew - Amsterdam [u.a.]: Elsevier, Bd. 361 (2006), 1, S. 94-104

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The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1

Kliche, Stefanie; Breitling, Dennis; Togni, Mauro; Pusch, Rico; Heuer, Katja; Wang, Xiaoqian; Freund, Christian; Kasirer-Friede, Ana; Menasche, Gael; Koretzky, Gary A.; Schraven, Burkhart

In: Molecular and cellular biology - Washington, DC : American Society for Microbiology, Bd. 26 (2006), Heft 19, S. 7130-7144

Lipid-binding hSH3 domains in immune cell adapter proteins

Heuer, Katja; Sylvester, Marc; Kliche, Stefanie; Pusch, Rico; Thiemke, Katharina; Schraven, Burkhart; Freund, Christian

In: Journal of molecular biology - Amsterdam [u.a.] : Elsevier, Bd. 361 (2006), Heft 1, S. 94-104

Fatal neonatal-onset mitochondrial respiratory chain disease with T cell immunodeficiency

Reichenbach, Janine; Schubert, Ralf; Horvàth, Rita; Petersen, Jens; Fütterer, Nancy; Malle, Elisabeth; Stumpf, Andreas; Gebhardt, Boris R.; Koehl, Ulrike; Schraven, Burkhart; Zielen, Stefan

In: Pediatric research: official journal of the Society for Pediatric Research, the American Pediatric Society, and the European Society for Paedriatic Research - New York: Springer Nature, Bd. 60 (2006), 3, S. 321-326

Publikationslink

CD26/DP IV in T cell activation and autoimmunity

Preller, Vera; Gerber, Annegret; Togni, Mauro; Wrenger, Sabine; Schraven, Burkhart; Röcken, Christoph; Marguet, Didier; Ansorge, Siegfried; Brocke, Stefan; Reinhold, Dirk

In: Dipeptidyl aminopeptidases - basic science and clinical applications , 1. Ed. - New York : Springer Science + Business Media , 2006, S. 187-193

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CD26/DP IV in T cell activation and autoimmunity

Preller, Vera; Gerber, Annegret; Togni, Mauro; Wrenger, Sabine; Schraven, Burkhart; Röcken, Christoph; Marguet, Didier; Ansorge, Siegfried; Brocke, Stefan; Reinhold, Dirk

In: Dipeptidyl aminopeptidases - New York: Springer Science + Business Media, 2006 . - 2006, S. 187-193

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The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.

Simeoni, Luca; Posevitz, Vilmos; Koelsch, Uwe; Meinert, Ines; Bruyns, E.; Pfeffer, K.; Reinhold, Dirk; Schraven, Burkhart

In: Mol. Cell. Biol. 25(2005), Nr. 17, S. 7557 - 7568

Right time, right place : the organization of membrane proximal signaling.

Simeoni, Luca; Smida, Michal; Posevitz, Vilmos; Schraven, Burkhart; Lindquist, Jonathan

In: Semin. Immunol. 17(2005), Nr. 1, S. 35 - 49

Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.

Togni, Mauro; Swanson, K.; Reimann, Sibylle; Kliche, Stefanie; Pearce, A.; Simeoni, Luca; Reinhold, Dirk; Wienands, J.; Neel, B.; Schraven, Burkhart; Gerber, Annegret

In: Mol. Cell. Biol. 25(2005), Nr. 18, S. 8052 - 8063

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.

Wang, Y.; Horvath, O.; Hamm-Baarke, Andrea; Richelme, M.; Grgoire, C.; Schraven, Burkhart; ...,

In: Mol. Cell. Biol. 25(2005), Nr. 11, S. 4455 - 4465

Adaptors and linkers in T and B cells.

Simeoni, Luca; Kliche, Stefanie; Lindquist, Jonathan; Schraven, Burkhart

In: Curr. Opin. Immunol. 16(2004), Nr. 3, S. 304 - 313

Transmembrane adaptor proteins : organizers of immunoreceptor signalling.

Horejs¡, V.; Zhang, W.; Schraven, Burkhart

In: Nat. Rev. Immunol. 4(2004), Nr. 8, S. 603 - 616

Transmembrane adapters : structure, biochemistry and biology.

Kliche, Stefanie; Lindquist, Jonathan; Schraven, Burkhart

In: Semin. Immunol. 16(2004), Nr. 6, S. 367 - 377

The role of adaptor proteins in lymphocyte activation.

Togni, Mauro; Lindquist, Jonathan; Gerber, Annegret; Koelsch, Uwe; Hamm-Baarke, Andrea; Kliche, Stefanie; Schraven, Burkhart

In: Mol. Immunol. 41(2004), Nr. 6-7, S. 615 - 630

Shp2 regulates Src family kinase activity and Ras/Erk activation by controlling Csk recruitment.

Zhang, S.; Yang, W.; Kontaridis, M.; Schraven, Burkhart; Philips, M.; Neel, B.

In: Mol. Cell 13(2004), Nr. 3, S. 341 - 355

Expression of cell surface antigens in diabetic patients and healthy controls after injury.

Lobmann, Ralf; Ittenson, Annelore; Schiweck, S.; Motzkau, Markus; Schraven, Burkhart; Winckler, Stephan; Lehnert, Hendrik

In: Diabetes Nutr. Metab. 17(2004), Nr. 4, S. 244 - 246

A novel flow cytometric assay focusing on perforin release mechanisms of cytotoxic T lymphocytes.

Weren, Andrea; Bonnekoh, Bernd; Schraven, Burkhart; Gollnick, Harald; Ambach, Andreas

In: J. Immunol. Methods 289(2004), Nr. 1-2, S. 17 - 26

Grb2 and the non-T cell activation linker NTAL constitute a Ca2+-regulating signal circuit in B lymphocytes.

Stork, B.; Engelke, M.; Frey, J.; Horejs¡, V.; Hamm-Baarke, Andrea; Schraven, Burkhart; Kurosaki, T.; Wienands, J.

In: Immunity 21(2004), Nr. 5, S. 681 - 691

Grundsätzliches und Neues aus der Immunologie.

Schraven, Burkhart

In: Dtsch. Z. Klin. Forsch. 8(2004), Nr. 9/10, [8 S.]

Transmembrane adapters : attractants for cytoplasmic effectors.

Lindquist, Jonathan; Simeoni, Luca; Schraven, Burkhart

In: Immunol. Rev. 191(2003), Nr. 1, S. 165 - 182

LIME : a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.

Brdickov, N.; Brdicka, T.; Schmidt, Peter; Simeoni, Luca; Kliche, Stefanie; Merten, Camilla; Schraven, Burkhart; Horejs¡, V.

In: J. Exp. Med. 198(2003), Nr. 10, S. 1453 - 1462

The activation of Csk by CD4 interferes with TCR-mediated activatory signaling.

Marinari, B.; Simeoni, Luca; Schraven, Burkhart; Piccolella, E.; Tuosto, L.

In: Eur. J. Immunol. 33(2003), Nr. 9, S. 2609 - 2618

Neue immologische Signale aus Magdeburg.

Schraven, Burkhart

In: Magdeburger Wissenschaftsjournal [Magdeburg] 8(2003), Nr. 1/2, S. 29 - 44

Perioperative Immunmodulation beim Nierenzellkarzinom.

Boehm, Malte; Klatte, T.; Ittenson, Annelore; Roehl, Friedrich Wilhelm; Ansorge, Siegfried; Schraven, Burkhart; Allhoff, Ernst Peter

In: Tumorzentrum aktuell(2003), Nr. 2, S. 10 - 18

Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein.

Fortin, M.; Steff, A.M.; Felberg, J.; Ding, I.; Schraven, Burkhart; Johnson, P.; Hugo, P.

In: J. Immunol. 168(2002), S. 6084 - 6089

Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin- mediated phospholipase Cg2 regulation in platelets.

Wonerow, P.; Obergfell, A.; Wilde, J.; Bobe, R.; Asazuma, N.; Brdika, T.; Leo, A.; Schraven, Burkhart; Hoeji, V.; Shattil, S.; Watson, S.

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Non-T cell activation linker (NTAL) : a transmembrane adaptor protein involved in immunoreceptor signaling.

Brdicka, T.; Imrich, M.; Schmidt, Peter; Brdickov, N.; Horv th, O.; Simeoni, Luca; Oesterreicher, J.; Aguado, E.; Malissen, M.; Schraven, Burkhart; Horejs¡, V.

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Process outgrowth of oligodendrocytes is promoted by interaction of Fyn kinase with the cytoskeletal protein Tau.

Klein, C.; Kraemer, E.M.; Cardine, A.M.; Schraven, Burkhart; Brandt, R.; Trotter, J.

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Adapters in lymphocyte signaling.

Leo, A.; Wienands, J.; Baier, G.; Horejsi, V.; Schraven, Burkhart

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