http://www.uni-magdeburg.de/search

Prof. Fendt

Prof. apl. Dr. rer. nat. Markus Fendt

Medizinische Fakultät
Institut für Pharmakologie und Toxikologie (IPT)
Haus 20a, Leipziger Straße 44, 39120, Magdeburg,
Tel.: +49 391 67 21982
Fax: +49 391 67 15869

Prof. apl. Dr. rer. nat. Markus Fendt

Medizinische Fakultät
Institut für Pharmakologie und Toxikologie (IPT)
Haus 20a, Leipziger Straße 44, 39120, Magdeburg,
Tel.: +49 391 67 21982
Fax: +49 391 67 15869
Projekte
Publikationen

2017

Begutachteter Zeitschriftenartikel
Vincenz, Daniel;  Wernecke, Kerstin E.A.;  Fendt, Markus;  Goldschmidt, Jürgen 

Habenula and interpeduncular nucleus differentially modulate predator odor-induced innate fear behavior in rats
In: Behavioural brain research: an international journal - Amsterdam: Elsevier, Bd. 332.2017, S. 164-171; http://dx.doi.org/10.1016/j.bbr.2017.05.053

Khalil, Radwa;  Fendt, Markus 

Increased anxiety but normal fear and safety learning in orexin-deficient mice
In: Behavioural brain research: an international journal - Amsterdam: Elsevier, Bd. 320.2017, S. 210-218; http://dx.doi.org/10.1016/j.bbr.2016.12.007

Bergado Acosta, Jorge R.;  Schneider, Miriam;  Fendt, Markus 

Intra-accumbal blockade of endocannabinoid CB1 receptors impairs learning but not retention of conditioned relief
In: Neurobiology of learning and memory - Orlando, Fla: Academic Press, Bd. 144.2017, S. 48-52; http://dx.doi.org/10.1016/j.nlm.2017.06.001

Fragoulis, Athanassios;  Siegl, Stephanie;  Fendt, Markus;  Jansen, Sandra;  Soppa, Ulf-Werner;  Brandenburg, Lars-Ove;  Pufe, Thomas;  Weis, Joachim;  Wruck, Christoph Jan 

Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease
In: Redox Biology: an official journal of the Society for Free Radical Biology and Medicine, an official journal of the Society for Free Radical Research-Europe, an affiliate journal of the International Society for Free Radical Research (SFRRI) - Amsterdam [u.a.]: Elsevier, Bd. 12.2017, S. 843-853; http://dx.doi.org/10.1016/j.redox.2017.04.024

Bergado Acosta, Jorge R.;  Kahl, Evelyn;  Kogias, Georgios;  Uzuneser, Taygun C.;  Fendt, Markus 

Relief learning requires a coincident activation of dopamine D1 and NMDA receptors within the nucleus accumbens
In: Neuropharmacology - Amsterdam [u.a.]: Elsevier Science, Bd. 114.2017, S. 58-66; http://dx.doi.org/10.1016/j.neuropharm.2016.11.022

2016

Begutachteter Zeitschriftenartikel
Fendt, Markus;  Kiyokawa, Yasushi;  Endres, Thomas 

Editorial - Scents that matter : from olfactory stimuli to genes, behaviors and beyond
In: Frontiers in neuroscience. - Lausanne : Frontiers Research Foundation; Bd. 10.2016, Art.-Nr. 29, insges. 3 S.

Kahl, Evelyn;  Fendt, Markus 

Metabotropic glutamate receptors 7 within the nucleus accumbens are involved in relief learning in rats
In: Current neuropharmacology. - Hilversum [u.a.] : Bentham Science Publ, Bd. 14.2016, 5, S. 405-412

Wernecke, Kerstin E. A.;  Brüggemann, Judith;  Fendt, Markus 

Predator odor exposure increases food-carrying behavior in rats
In: Physiology & behavior : official journal of the International Behavioral Neuroscience Society. - Amsterdam [u.a.] : Elsevier Science, Bd. 154.2016, S. 15-19

Bruning, Johann E.A.;  Breitfeld, Tino;  Kahl, Evelyn;  Bergado-Acosta, Jorge R.;  Fendt, Markus 

Relief memory consolidation requires protein synthesis within the nucleus accumbens
In: Neuropharmacology. - Amsterdam [u.a.] : Elsevier Science, Bd. 105.2016, S. 10-14

Schmidt, Christian;  Leibiger, Judith;  Fendt, Markus 

The norepinephrine reuptake inhibitor reboxetine is more potent in treating murine narcoleptic episodes than the serotonin reuptake inhibitor escitalopram
In: Behavioural brain research : an international journal. - Amsterdam : Elsevier, Bd. 308.2016, S. 205-210

Herausgeberschaft
Fendt, Markus [HerausgeberIn];  Kiyokawa, Yasushi [HerausgeberIn];  Endres, Thomas [HerausgeberIn] 

Scents that matter - from olfactory stimuli to genes, behaviors and beyond
In: Lausanne: Frontiers Media, 2016; 256 Seiten - (Frontiers Research Topics)

2015

Begutachteter Zeitschriftenartikel
Shanmugasundaram, Bharanidharan;  Korz, Volker;  Fendt, Markus;  Braun, Katharina;  Lubec, Gert 

Differential effects of wake promoting drug modafinil in aversive learning paradigms
In: Frontiers in behavioral neuroscience. - Lausanne : Frontiers Research Foundation; Bd. 9.2015, Art.-Nr. 220, insges. 9 S.

Behnke, D.;  Cotesta, S.;  Hintermann, S.;  Fendt, M.;  Gee, C.E.;  Jacobson, L.H.;  Laue, G.;  Meyer, A.;  Wagner, T.;  Badiger, S.;  Chaudhari, V.;  Chebrolu, M.;  Pandit, C.;  Hoyer, D.;  Betschart, C. 

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs)
In: Bioorganic and Medicinal Chemistry Letters, Vol. 25, 2015, Issue 23, S. 5555-5560, 10.1016/j.bmcl.2015.10.055

Daldrup, Thiemo;  Remmes, Jasmin;  Lesting, Jörg;  Gaburro, Stefano;  Fendt, Markus;  Meuth, Patrick;  Kloke, Vanessa;  Pape, Hans-Christian;  Seidenbecher, Thomas 

Expression of freezing and fear-potentiated startle during sustained fear in mice
In: Genes, brain and behavior : official journal of IBANGS - International Behavioural and Neural Genetics Society. - Copenhagen [u.a.] : Blackwell Munksgaard, Bd. 14.2015, 3, S. 281-291

Wernecke, Kerstin E.A.;  Vincenz, Daniel;  Storsberg, Silke;  Dʾ  Hanis, Wolfgang;  Goldschmidt, Jürgen;  Fendt, Markus 

Fox urine exposure induces avoidance behavior in rats and activates the amygdalar olfactory cortex
In: Behavioural brain research : an international journal. - Amsterdam : Elsevier, Bd. 279.2015, S. 76-81

Wernecke, K.E.A.;  Vincenz, D.;  Storsberg, S.;  D’  Hanis, W.;  Goldschmidt, J.;  Fendt, M. 

Fox urine exposure induces avoidance behavior in rats and activates the amygdalar olfactory cortex
In: Behavioural Brain Research, 2015, S. 76-81, ISSN 01664328, 10.1016/j.bbr.2014.11.020

Mohammadi, Milad;  Fendt, Markus 

Relief learning is dependent on NMDA receptor activation in the nucleus accumbens
In: British journal of pharmacology : BJP online. - Malden, MA : Wiley, Bd. 172.2015, 9, S. 2419-2426

Chindo, Ben A.;  Kahl, Evelyn;  Trzeczak, Doris;  Dehmel, Petra;  Becker, Axel;  Fendt, Markus 

Standardized extract of Ficus platyphylla reverses apomorphine-induced changes in prepulse inhibition and locomotor activity in rats
In: Behavioural brain research : an international journal. - Amsterdam : Elsevier, Bd. 293.2015, S. 74-80

Breitfeld, Tino;  Bruning, Johann E. A.;  Inagaki, Hideaki;  Takeuchi, Yukari;  Kiyokawa, Yasushi;  Fendt, Markus 

Temporary inactivation of the anterior part of the bed nucleus of the stria terminalis blocks alarm pheromone-induced defensive behavior in rats
In: Frontiers in neuroscience. - Lausanne : Frontiers Research Foundation; Bd. 9.2015, Art.-Nr. 321, insges. 8 S.

Wernecke, Kerstin, E. A.;  Fendt, Markus 

The olfactory hole-board test in rats - a new paradigm to study aversion and preferences to odors
In: Frontiers in behavioral neuroscience. - Lausanne : Frontiers Research Foundation; Bd. 9.2015, Art.-Nr. 223, insges. 9 S.

2014

Begutachteter Zeitschriftenartikel
Leibiger, Judith;  Fendt, Markus 

Behavioral analysis of narcoleptic episodes in orexin-deficient mice
In: Behavior genetics : an international journal devoted to research in the inheritance of behavior in animals and man. - Dordrecht [u.a.] : Springer Science + Business Media B.V, Bd. 44.2014, 2, S. 136-143

Gee, Christine E.;  Peterlik, Daniel;  Neuhäuser, Christoph;  Bouhelal, Rochdi;  Kaupmann, Klemens;  Laue, Grit;  Uschold-Schmidt, Nicole;  Feuerbach, Dominik;  Zimmermann, Kaspar;  Ofner, Silvio;  Cryan, John F.;  Putten, Herman van der;  Fendt, Markus;  Vranesic, Ivo;  Glatthar, Ralf;  Flor, Peter J. 

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior
In: The journal of biological chemistry. - Bethesda, Md : Soc, Bd. 289.2014, 16, S. 10975-10987

Gee, C.E.;  Peterlik, D.;  Neuhäuser, C.;  Bouhelal, R.;  Kaupmann, K.;  Laue, G.;  Uschold-Schmidt, N.;  Feuerbach, D.;  Zimmermann, K.;  Ofner, S.;  Cryan, J.F.;  Van Der Putten, H.;  Fendt, M.;  Vranesic, I.;  Glatthar, R.;  Flor, P.J. 

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior
In: Journal of Biological Chemistry, Vol. 289, 2014, Issue 16, S. 10975-10987, 10.1074/jbc.M113.542654

Auberson, Yves P.;  Troxler, Thomas;  Zhang, Xuechun;  Yang, Charles R.;  Fendt, Markus;  Feuerbach, Dominik;  Liu, Yu-Chih;  Lagu, Bharat;  Lerchner, Andreas;  Perrone, Mark;  Lei, Lijun;  Zhang, Chao;  Wang, Chunxiu;  Wang, Tie-Lin;  Bock, Mark G. 

Ergoline-derived inverse agonists of the human H3 receptor for the treatment of narcolepsy
In: ChemMedChem : chemistry enabling drug discovery. - Weinheim [u.a.] : Wiley-VCH, Bd. 9.2014, 8, S. 1683-1696

Saumweber, Timo;  Cano, Carmen;  Klessen, Juliane;  Eichler, Katharina;  Fendt, Markus;  Gerber, Bertram 

Immediate and punitive impact of mechanosensory disturbance on olfactory behaviour of larval Drosophila
In: Biology open : BiO. - Cambridge : Company, Bd. 3.2014, S. 1005-1010

Kahl, Evelyn;  Fendt, Markus 

Injections of the somatostatin receptor type 2 agonist L-054,264 into the amygdala block expression but not acquisition of conditioned fear in rats
In: Behavioural brain research : an international journal. - Amsterdam : Elsevier, Bd. 265.2014, S. 49-52

Gerber, Bertram;  Yarali, Ayse;  Diegelmann, Sören;  Wotjak, Carsten T.;  Pauli, Paul;  Fendt, Markus 

Pain-relief learning in flies, rats, and man - basic research and applied perspectives
In: Learning & memory. - Plainview, NY : Cold Spring Harbor Laboratory Press, Bd. 21.2014, 4, S. 232-252

Gerber, B.;  Yarali, A.;  Diegelmann, S.;  Wotjak, C.T.;  Pauli, P.;  Fendt, M. 

Pain-relief learning in flies, rats, and man: Basic research and applied perspectives
In: Learning and Memory, Vol. 21, 2014, Issue 4, S. 232-252, ISSN 10720502, 10.1101/lm.032995.113

Mohammadi, Milad;  Bergado-Acosta, Jorge R.;  Fendt, Markus 

Relief learning is distinguished from safety learning by the requirement of the nucleus accumbens
In: Behavioural brain research : an international journal. - Amsterdam : Elsevier, Bd. 272.2014, S. 40-45

2013

Begutachteter Zeitschriftenartikel
Fendt, Markus;  Imobersteg, Stefan;  Peterlik, Daniel;  Chaperon, Frédérique;  Mattes, Catherine;  Wittmann, Christina;  Olpe, Hans-Rudolf;  Mosbacher, Johannes;  Vranesic, Ivo;  Putten, Herman van der;  McAllister, Kevin H.;  Flor, Peter J.;  Gee, Christine E. 

Differential roles of mGlu7 and mGlu8 in amygdala-dependent behavior and physiology
In: Neuropharmacology. - Amsterdam [u.a.] : Elsevier Science, Bd. 72.2013, S. 215-223

Hoyer, Daniel;  Dürst, Thomas;  Fendt, Markus;  Jacobson, Laura H.;  Betschart, Claudia;  Hintermann, Samuel;  Behnke, Dirk;  Cotesta, Simona;  Laue, Grit;  Ofner, Silvio;  Legangneux, Eric;  Gee, Christine E. 

Distinct effects of IPSU and suvorexant on mouse sleep architecture
In: Frontiers in neuroscience. - Lausanne : Frontiers Research Foundation; Bd. 7.2013, Art.-Nr. 235, insges. 6 S.

Betschart, C.;  Hintermann, S.;  Behnke, D.;  Cotesta, S.;  Fendt, M.;  Gee, C.E.;  Jacobson, L.H.;  Laue, G.;  Ofner, S.;  Chaudhari, V.;  Badiger, S.;  Pandit, C.;  Wagner, J.;  Hoyer, D. 

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia
In: Journal of Medicinal Chemistry, Vol. 56, 2013, Issue 19, S. 7590-7607, 10.1021/jm4007627

Callander, Gabrielle E.;  Olorunda, Morenike;  Monna, Dominique;  Schuepbach, Edi;  Langenegger, Daniel;  Betschart, Claudia;  Hintermann, Samuel;  Behnke, Dirk;  Cotesta, Simona;  Fendt, Markus;  Laue, Grit;  Ofner, Silvio;  Briard, Emmanuelle;  Gee, Christine E.;  Jacobson, Laura H.;  Hoyer, Daniel 

Kinetic properties of "dualʺ orexin receptor antagonists at OX1R and OX2R orexin receptors
In: Frontiers in neuroscience. - Lausanne : Frontiers Research Foundation; Bd. 7.2013, Art.-Nr. 230, insges. 10 S.

Fendt, Markus;  Koch, Michael 

Translational value of startle modulations
In: Cell & tissue research. - Berlin : Springer, Bd. 354.2013, 1, S. 287-295

2012

Begutachteter Zeitschriftenartikel
Chaperon, Frederique;  Fendt, Markus;  Kelly, Peter H;  Lingenhoehl, Kurt;  Mosbacher, Johannes;  Olpe, Hans-Rudolf;  Schmid, Peter;  Sturchler, Christine;  McAllister, Kevin H;  van der Putten, P Herman;  Gee, Christine E 

Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory.
In: PloS one, Vol. 7, ISSN 1932-6203, 2012, 10.1371/journal.pone.0034963

Andreatta, Marta;  Fendt, Markus;  Mühlberger, Andreas;  Wieser, Matthias J;  Imobersteg, Stefan;  Yarali, Ayse;  Gerber, Bertram;  Pauli, Paul 

Onset and offset of aversive events establish distinct memories requiring fear and reward networks.
In: Learning & memory (Cold Spring Harbor, N.Y.), Vol. 19, ISSN 1549-5485, 2012, 10.1101/lm.026864.112

Li, Qian;  Korzan, Wayne J;  Ferrero, David M;  Chang, Rui B;  Roy, Dheeraj S;  Buchi, Mélanie;  Lemon, Jamie K;  Kaur, Angeldeep W;  Stowers, Lisa;  Fendt, Markus;  Liberles, Stephen D 

Synchronous evolution of an odor biosynthesis pathway and behavioral response.
In: Current biology : CB, Vol. 23, ISSN 1879-0445, 2012, 10.1016/j.cub.2012.10.047

Morawska, M.M.;  Fendt, M. 

The effects of muscimol and AMN082 injections into the medial prefrontal cortex on the expression and extinction of conditioned fear in mice
In: Journal of Experimental Biology, Vol. 215, 2012, Issue 8, S. 1394-1398, 10.1242/jeb.068213

Originalartikel in begutachteter internationaler Zeitschrift
Mang, Géraldine M.;  Dürst, Thomas;  Bürki, Hugo;  Imobersteg, Stefan;  Abramowski, Dorothee;  Schuepbach, Edi;  Hoyer, Daniel;  Fendt, Markus;  Gee, Christine E. 

The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors
In: Sleep : official publication of the Associated Professional Sleep Societies, LLC (APSS), a joint venture of the American Academy of Sleep Medicine and the Sleep Research Society. - Darien, Ill, Bd. 35.2012, 12, S. 1625-1635

2011

Begutachteter Zeitschriftenartikel
Leiner, L.;  Fendt, M. 

Behavioural fear and heart rate responses of horses after exposure to novel objects: Effects of habituation
In: Applied Animal Behaviour Science, Vol. 131, 2011, Issue 3-4, S. 104-109, 10.1016/j.applanim.2011.02.004

Carcache, D.;  Vranesic, I.;  Blanz, J.;  Desrayaud, S.;  Fendt, M.;  Glatthar, R. 

Benzimidazoles as potent and orally active mGlu5 receptor antagonists with an improved pk profile
In: ACS Medicinal Chemistry Letters, Vol. 2, 2011, Issue 1, S. 58-62, 10.1021/ml100215b

Ferrero, David M;  Lemon, Jamie K;  Fluegge, Daniela;  Pashkovski, Stan L;  Korzan, Wayne J;  Datta, Sandeep Robert;  Spehr, Marc;  Fendt, Markus;  Liberles, Stephen D 

Detection and avoidance of a carnivore odor by prey.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, ISSN 1091-6490, 2011, 10.1073/pnas.1103317108

Morawska, Marta;  Buchi, Mélanie;  Fendt, Markus 

Narcoleptic episodes in orexin-deficient mice are increased by both attractive and aversive odors.
In: Behavioural brain research, Vol. 222, ISSN 1872-7549, 2011, 10.1016/j.bbr.2011.04.005

Nuber, Silke;  Petrasch-Parwez, Elisabeth;  Arias-Carrión, Oscar;  Koch, Leanie;  Kohl, Zacharias;  Schneider, Jacqueline;  Calaminus, Carsten;  Dermietzel, Rolf;  Samarina, Anna;  Boy, Jana;  Nguyen, Huu P;  Teismann, Peter;  Velavan, Thirumalaisamy Palanichamy;  Kahle, Philipp J;  von Hörsten, Stephan;  Fendt, Markus;  Krüger, Rejko;  Riess, Olaf 

Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.
In: Neurobiology of disease, Vol. 44, ISSN 1095-953X, 2011, 10.1016/j.nbd.2011.06.017

Toth, Iulia;  Dietz, Monika;  Peterlik, Daniel;  Huber, Sabine E;  Fendt, Markus;  Neumann, Inga D;  Flor, Peter J;  Slattery, David A 

Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear.
In: Neuropharmacology, Vol. 62, ISSN 1873-7064, 2011, 10.1016/j.neuropharm.2011.10.021

Schmitt, A.;  Gebicke-Haerter, P.;  Sommer, U.;  Heck, M.;  Lex, A.;  Herrera-Marschitz, M.;  Zink, M.;  Fendt, M.;  Falkai, P. 

The hypoxic rat model for obstetric complications in schizophrenia
In: Neuromethods, Vol. 59, 2011, S. 93-111, 10.1007/978-1-61779-157-4_4

Originalartikel in begutachteter internationaler Zeitschrift
Endres, Thomas;  Fendt, Markus 

Aversion- vs fear-inducing properties of 2,4,5-trimethyl-3-thiazoline, a component of fox odor, in comparison with those of butyric acid.
In: Experimental Biology, 2009, 2324-2327

2010

Begutachteter Zeitschriftenartikel
Sommer, J U;  Schmitt, A;  Heck, M;  Schaeffer, E L;  Fendt, M;  Zink, M;  Nieselt, K;  Symons, S;  Petroianu, G;  Lex, A;  Herrera-Marschitz, M;  Spanagel, R;  Falkai, P;  Gebicke-Haerter, P J 

Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia.
In: European archives of psychiatry and clinical neuroscience, Vol. 260 Suppl 2, ISSN 1433-8491, 2010, 10.1007/s00406-010-0159-1

Schmid, S.;  Brown, T.;  Simons-Weidenmaier, N.;  Weber, M.;  Fendt, M. 

Group III metabotropic glutamate receptors inhibit startle-mediating giant neurons in the caudal pontine reticular nucleus but do not mediate synaptic depression/short-term habituation of startle
In: Journal of Neuroscience, Vol. 30, 2010, Issue 31, S. 10422-10430, 10.1523/JNEUROSCI.0024-10.2010

Fendt, Markus;  Imobersteg, Stefan;  Bürki, Hugo;  McAllister, Kevin H;  Sailer, Andreas W 

Intra-amygdala injections of neuropeptide S block fear-potentiated startle.
In: Neuroscience letters, Vol. 474, ISSN 1872-7972, 2010, 10.1016/j.neulet.2010.03.028

Fendt, Markus;  Buchi, Mélanie;  Bürki, Hugo;  Imobersteg, Stefan;  Ricoux, Bérangère;  Suply, Thomas;  Sailer, Andreas W 

Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response.
In: Behavioural brain research, Vol. 217, ISSN 1872-7549, 2010, 10.1016/j.bbr.2010.09.022

2009

Begutachteter Zeitschriftenartikel
Mohr, Daniela;  von Ameln-Mayerhofer, Andreas;  Fendt, Markus 

5,7-dihydroxytryptamine injections into the prefrontal cortex and nucleus accumbens differently affect prepulse inhibition and baseline startle magnitude in rats.
In: Behavioural brain research, Vol. 202, ISSN 1872-7549, 2009, 10.1016/j.bbr.2009.03.014

Endres, T.;  Fendt, M. 

Aversion- Vs fear-inducing properties of 2,4,5-trimethyl-3-thiazoline, a component of fox odor, in comparison with those of butyric acid
In: Journal of Experimental Biology, Vol. 212, 2009, Issue 15, S. 2324-2327, 10.1242/jeb.028498

Fendt, Markus;  Bürki, Hugo;  Imobersteg, Stefan;  Lingenhöhl, Kurt;  McAllister, Kevin H;  Orain, David;  Uzunov, Doncho P;  Chaperon, Frederique 

Fear-reducing effects of intra-amygdala neuropeptide Y infusion in animal models of conditioned fear: an NPY Y1 receptor independent effect.
In: Psychopharmacology, Vol. 206, ISSN 1432-2072, 2009, 10.1007/s00213-009-1610-8

Kindermann, T.;  Siemers, B.M.;  Fendt, M. 

Innate or learned acoustic recognition of avian predators in rodents?
In: Journal of Experimental Biology, Vol. 212, 2009, Issue 4, S. 506-513, 10.1242/jeb.024174

Spanka, Carsten;  Glatthar, Ralf;  Desrayaud, Sandrine;  Fendt, Markus;  Orain, David;  Troxler, Thomas;  Vranesic, Ivo 

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.
In: Bioorganic & medicinal chemistry letters, Vol. 20, ISSN 1464-3405, 2009, 10.1016/j.bmcl.2009.11.001

Fendt, M;  Bürki, H;  Imobersteg, S;  van der Putten, H;  McAllister, K;  Leslie, J C;  Shaw, D;  Hölscher, C 

The effect of mGlu8 deficiency in animal models of psychiatric diseases.
In: Genes, brain, and behavior, Vol. 9, ISSN 1601-183X, 2009, 10.1111/j.1601-183X.2009.00532.x

Originalartikel in begutachteter internationaler Zeitschrift
Endres, Thomas;  Fendt, Markus 

Aversion- vs fear-inducing properties of 2,4,5-trimethyl-3-thiazoline, a component of fox odor, in comparison with those of butyric acid
In: The journal of experimental biology . - Cambridge : Company of Biologists, Bd. 212.2009, 15, S. 2324-2327

2008

Begutachteter Zeitschriftenartikel
Fendt, M.;  Endres, T. 

2,3,5-Trimethyl-3-thiazoline (TMT), a component of fox odor - Just repugnant or really fear-inducing?
In: Neuroscience and Biobehavioral Reviews, Vol. 32, 2008, Issue 7, S. 1259-1266, 10.1016/j.neubiorev.2008.05.010

Siegl, S.;  Flor, P.J.;  Fendt, M. 

Amygdaloid metabotropic glutamate receptor subtype 7 is involved in the acquisition of conditioned fear
In: NeuroReport, Vol. 19, 2008, Issue 11, S. 1147-1150, 10.1097/WNR.0b013e328307f295

Fendt, M.;  Lex, A.;  Falkai, P.;  Henn, F.A.;  Schmitt, A. 

Behavioural alterations in rats following neonatal hypoxia and effects of clozapine: Implications for schizophrenia
In: Pharmacopsychiatry, Vol. 41, 2008, Issue 4, S. 138-145, 10.1055/s-2008-1058107

Originalartikel in begutachteter internationaler Zeitschrift
Fendt, Markus;  Endres, Thomas 

2,3,5-Trimethyl-3-thiazoline (TMT), a component of fox odor - just repugnant or really fear-inducing?
In: Neuroscience, Biobehavioral Reviews, 2008; 1259-66

Endres, Thomas;  Fendt, Markus 

Inactivation of the lateral septum blocks fox odor-induced fear behavior
In: NeuroReport, 2008, 16: 667-670

2007

Begutachteter Zeitschriftenartikel
Mohr, D.;  Pilz, P.K.D.;  Plappert, C.F.;  Fendt, M. 

Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice
In: NeuroReport, Vol. 18, 2007, Issue 14, S. 1493-1497, 10.1097/WNR.0b013e3282e9a863

Endres, T.;  Fendt, M. 

Conditioned Behavioral Responses to a Context Paired With the Predator Odor Trimethylthiazoline
In: Behavioral Neuroscience, Vol. 121, 2007, Issue 3, S. 594-601, 10.1037/0735-7044.121.3.594

Fendt, M;  Schmid, S;  Thakker, D R;  Jacobson, L H;  Yamamoto, R;  Mitsukawa, K;  Maier, R;  Natt, F;  Hüsken, D;  Kelly, P H;  McAllister, K H;  Hoyer, D;  van der Putten, H;  Cryan, J F;  Flor, P J 

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.
In: Molecular psychiatry, Vol. 13, ISSN 1476-5578, 2007, 10.1038/sj.mp.4002073

Originalartikel in begutachteter internationaler Zeitschrift
Endres, Thomas;  Widmann, Katrin;  Fendt, Markus 

Are rats predisposed to learn 22 kHz calls as danger-predicting signals
In: Behavioural Brain Research, 2007, 69-75

Endres, Thomas;  Fendt, Markus 

Conditioned behavioral responses to a context paired with the predator odor trimethylthiazoline
In: Behavioral Neuroscience, 2007, 594-601

2006

Begutachteter Zeitschriftenartikel
Schmitt, A;  Fendt, M;  Zink, M;  Ebert, U;  Starke, M;  Berthold, M;  Herb, A;  Petroianu, G;  Falkai, P;  Henn, F A 

Altered NMDA receptor expression and behavior following postnatal hypoxia: potential relevance to schizophrenia.
In: Journal of neural transmission (Vienna, Austria : 1996), Vol. 114, ISSN Print0300-9564, 2006, 10.1007/s00702-006-0440-7

Schwienbacher, I;  Schnitzler, H-U;  Westbrook, R F;  Richardson, R;  Fendt, M 

Carbachol injections into the nucleus accumbens disrupt acquisition and expression of fear-potentiated startle and freezing in rats.
In: Neuroscience, Vol. 140, ISSN Print0306-4522, 2006, 10.1016/j.neuroscience.2006.02.052

Fendt, Markus;  Schwienbacher, Isabel;  Schnitzler, Hans-Ulrich 

Carbachol injections into the nucleus accumbens induce 50 kHz calls in rats.
In: Neuroscience letters, Vol. 401, ISSN Print0304-3940, 2006, 10.1016/j.neulet.2006.02.069

Fendt, M. 

Exposure to urine of canids and felids, but not of herbivores, induces defensive behavior in laboratory rats
In: Journal of Chemical Ecology, Vol. 32, 2006, Issue 12, S. 2617-2627, 10.1007/s10886-006-9186-9

Pfeiffer, U.J.;  Fendt, M. 

Prefrontal dopamine D4 receptors are involved in encoding fear extinction
In: NeuroReport, Vol. 17, 2006, Issue 8, S. 847-850, 10.1097/01.wnr.0000220142.29413.6f

Herausgeberschaft
Fendt, M. 

Animal models of fear and anxiety
In: Animal Models of Neuropsychiatric Diseases, 2006, S. 293-336, 10.1142/9781860948022_0007

2005

Anderes Material
Banjaw, Mehret Yerdaw;  Fendt, Markus;  Schmidt, Werner J 

Clozapine attenuates the locomotor sensitisation and the prepulse inhibition deficit induced by a repeated oral administration of Catha edulis extract and cathinone in rats.
In: Behavioural brain research, Vol. 160, ISSN Print0166-4328, 2005, 10.1016/j.bbr.2005.01.002

Schmid, Susanne;  Fendt, Markus 

Effects of the mGluR8 agonist (S)-3,4-DCPG in the lateral amygdala on acquisition/expression of fear-potentiated startle, synaptic transmission, and plasticity.
In: Neuropharmacology, Vol. 50, ISSN Print0028-3908, 2005, 10.1016/j.neuropharm.2005.08.002

Müller, Martin;  Fendt, Markus 

Temporary inactivation of the medial and basolateral amygdala differentially affects TMT-induced fear behavior in rats.
In: Behavioural brain research, Vol. 167, ISSN Print0166-4328, 2005, 10.1016/j.bbr.2005.08.016

Begutachteter Zeitschriftenartikel
Laska, M.;  Fendt, M.;  Wieser, A.;  Endres, T.;  Hernandez Salazar, L.T.;  Apfelbach, R. 

Detecting danger - Or just another odorant? Olfactory sensitivity for the fox odor component 2,4,5-trimethylthiazoline in four species of mammals
In: Physiology and Behavior, Vol. 84, 2005, Issue 2, S. 211-215, 10.1016/j.physbeh.2004.11.006

Fendt, M.;  Fanselow, M.S.;  Koch, M. 

Lesions of the dorsal hippocampus block trace fear conditioned potentiation of startle
In: Behavioral Neuroscience, Vol. 119, 2005, Issue 3, S. 834-838, 10.1037/0735-7044.119.3.834

Fendt, M.;  Siegl, S.;  Steiniger-Brach, B. 

Noradrenaline transmission within the ventral bed nucleus of the stria terminalis is critical for fear behavior induced by trimethylthiazoline, a component of fox odor
In: Journal of Neuroscience, Vol. 25, 2005, Issue 25, S. 5998-6004, 10.1523/JNEUROSCI.1028-05.2005

Schulz-Klaus, B.;  Fendt, M.;  Schnitzler, H.-U. 

Temporary inactivation of the rostral perirhinal cortex induces an anxiolytic-like effect on the elevated plus-maze and on the yohimbine-enhanced startle response
In: Behavioural Brain Research, Vol. 163, 2005, Issue 2, S. 168-173, 10.1016/j.bbr.2005.04.022

Originalartikel in begutachteter internationaler Zeitschrift
Endres, Thomas;  Apfelbach, Raimund;  Fendt, Markus 

Behavioral changes induced in rats by exposure to trimethylthiazoline, a component of fox odor
In: Behavioral Neuroscience, 2005, 1004-1010

Laska, Matthias;  Fendt, Markus;  Wieser, Alexandra;  Endres, Thomas;  Laura Teresa Hernandez Salazar;  Apfelbach, Raimund 

Detecting danger--or just another odorant? Olfactory sensitivity for the fox odor component 2,4,5-trimethylthiazoline in four species of mammals.
In: Physiology & Behavior, 2005, 211-215

Fendt, Markus;  Endres, Thomas;  Lowry, Catherine;  Apfelbach, Raimund;  McGregor, Iain 

TMT-induced autonomic and behavioral changes and the neural basis of its processing
In: Neuroscience Biobehavioral Reviews, 2005, 1145-1156

2004

Anderes Material
Schweimer, Judith;  Fendt, Markus;  Schnitzler, Hans-Ulrich 

Effects of clonidine injections into the bed nucleus of the stria terminalis on fear and anxiety behavior in rats.
In: European journal of pharmacology, Vol. 507, ISSN Print0014-2999, 2004, 10.1016/j.ejphar.2004.11.044

Begutachteter Zeitschriftenartikel
Schwienbacher, Isabel;  Fendt, Markus;  Schnitzler, Hans-Ulrich 

Amphetamine injections into the nucleus accumbens affect neither acquisition/expression of conditioned fear nor baseline startle response.
In: Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, Vol. 160, ISSN Print0014-4819, 2004, 10.1007/s00221-004-2160-2

Schwienbacher, I.;  Fendt, M.;  Richardson, R.;  Schnitzler, H.-U. 

Temporary inactivation of the nucleus accumbens disrupts acquisition and expression of fear-potentiated startle in rats
In: Brain Research, Vol. 1027, 2004, Issue 1-2, S. 87-93, 10.1016/j.brainres.2004.08.037

Schulz, B.;  Fendt, M.;  Richardson, R.;  Schnitzler, H.-U. 

Temporary inactivation of the perirhinal cortex by muscimol injections block acquisition and expression of fear-potentiated startle
In: European Journal of Neuroscience, Vol. 19, 2004, Issue 3, S. 713-720, 10.1111/j.1460-9568.2004.03180.x

2003

Originalartikel in begutachteter internationaler Zeitschrift
Fendt, Markus;  Endres, Thomas;  Apfelbach, Raimund 

Temporary inactivation of the bed nucleus of the stria terminalis but not of the amygdala blocks freezing induced by trimethylthiazoline, a component of fox feces
In: Journal of Neuroscience, 2003, 23-28

2002

Begutachteter Zeitschriftenartikel
Schulz, B.;  Fendt, M.;  Schnitzler, H.-U. 

Clonidine injections into the lateral nucleus of the amygdala block acquisition and expression of fear-potentiated startle
In: European Journal of Neuroscience, Vol. 15, 2002, Issue 1, S. 151-157, 10.1046/j.0953-816x.2001.01831.x

Schwienbacher, I.;  Fendt, M.;  Hauber, W.;  Koch, M. 

Dopamine D<inf>1</inf> receptors and adenosine A<inf>1</inf> receptors in the rat nucleus accumbens regulate motor activity but not prepulse inhibition
In: European Journal of Pharmacology, Vol. 444, 2002, Issue 3, S. 161-169, 10.1016/S0014-2999(02)01622-9

Fendt, M.;  Schmid, S. 

Metabotropic glutamate receptors are involved in amygdaloid plasticity
In: European Journal of Neuroscience, Vol. 15, 2002, Issue 9, S. 1535-1541, 10.1046/j.1460-9568.2002.01988.x

2001

Begutachteter Zeitschriftenartikel
Fendt, M.;  Mucha, R.F. 

Anxiogenic-like effects of opiate withdrawal seen in the fear-potentiated startle test, an interdisciplinary probe for drug-related motivational states
In: Psychopharmacology, Vol. 155, 2001, Issue 3, S. 242-250, 10.1007/s002130100709

Fendt, M.;  Li, L.;  Yeomans, J.S. 

Brain stem circuits mediating prepulse inhibition of the startle reflex
In: Psychopharmacology, Vol. 156, 2001, Issue 2-3, S. 216-224, 10.1007/s002130100794

Fendt, M. 

Injections of the NMDA receptor antagonist aminophosphonopentanoic acid into the lateral nucleus of the amygdala block the expression of fear-potentiated startle and freezing
In: Journal of Neuroscience, Vol. 21, 2001, Issue 11, S. 4111-4115

Schulz, B.;  Fendt, M.;  Pedersen, V.;  Koch, M. 

Sensitization of prepulse inhibition deficits by repeated administration of dizocilpine
In: Psychopharmacology, Vol. 156, 2001, Issue 2-3, S. 177-181, 10.1007/s002130100776

Schulz, B.;  Fendt, M.;  Gasparini, F.;  Lingenhöhl, K.;  Kühn, R.;  Koch, M. 

The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats
In: Neuropharmacology, Vol. 41, 2001, Issue 1, S. 1-7, 10.1016/S0028-3908(01)00036-3

2000

Begutachteter Zeitschriftenartikel
Fendt, M.;  Schwienbacher, I.;  Koch, M. 

Amygdaloid N-methyl-D-aspartate and γ-aminobutyric acid(A) receptors regulate sensorimotor gating in a dopamine-dependent way in rats
In: Neuroscience, Vol. 98, 2000, Issue 1, S. 55-60, 10.1016/S0306-4522(00)00086-5

Fendt, M. 

Expression and conditioned inhibition of fear-potentiated startle after stimulation and blockade of AMPA/Kainate and GABA(A) receptors in the dorsal periaqueductal gray
In: Brain Research, Vol. 880, 2000, Issue 1-2, S. 1-10, 10.1016/S0006-8993(00)02665-2

Koch, M.;  Fendt, M.;  Kretschmer, B.D. 

Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats
In: Behavioural Brain Research, Vol. 117, 2000, Issue 1-2, S. 153-162, 10.1016/S0166-4328(00)00299-0

Wagner, T.;  Pilz, P.K.D.;  Fendt, M. 

The superior olivary complex is necessary for the full expression of the acoustic but not tactile startle response in rats
In: Behavioural Brain Research, Vol. 108, 2000, Issue 2, S. 181-188, 10.1016/S0166-4328(99)00146-1

1999

Begutachteter Zeitschriftenartikel
Fendt, M.;  Koch, M. 

Cholinergic modulation of the acoustic startle response in the caudal pontine reticular nucleus of the rat
In: European Journal of Pharmacology, Vol. 370, 1999, Issue 2, S. 101-107, 10.1016/S0014-2999(99)00156-9

Fendt, M. 

Enhancement of prepulse inhibition after blockade of GABA activity within the superior colliculus
In: Brain Research, Vol. 833, 1999, Issue 1, S. 81-85, 10.1016/S0006-8993(99)01525-5

Fendt, M.;  Fanselow, M.S. 

The neuroanatomical and neurochemical basis of conditioned fear
In: Neuroscience and Biobehavioral Reviews, Vol. 23, 1999, Issue 5, S. 743-760, 10.1016/S0149-7634(99)00016-0

1998

Begutachteter Zeitschriftenartikel
Fendt, M. 

Different regions of the periaqueductal grey are involved differently in the expression and conditioned inhibition of fear-potentiated startle
In: European Journal of Neuroscience, Vol. 10, 1998, Issue 12, S. 3876-3884, 10.1046/j.1460-9568.1998.00395.x

1997

Begutachteter Zeitschriftenartikel
Fendt, M. 

Corticotropin-releasing factor in the caudal pontine reticular nucleus mediates the expression of fearpotentiated startle in the rat
In: European Journal of Neuroscience, Vol. 9, 1997, Issue 2, S. 299-305

Schwegler, H.;  Pilz, P.K.D.;  Koch, M.;  Fendt, M.;  Linke, R.;  Driscoll, P. 

The acoustic startle response in inbred Roman high- and low-avoidance rats
In: Behavior Genetics, Vol. 27, 1997, Issue 6, S. 579-582, 10.1023/A:1021465217299

1996

Begutachteter Zeitschriftenartikel
Fendt, M.;  Koch, M.;  Schnitzler, H.-U. 

Lesions of the central gray block conditioned fear as measured with the potentiated startle paradigm
In: Behavioural Brain Research, Vol. 74, 1996, Issue 1-2, S. 127-134, 10.1016/0166-4328(96)82984-6

Fendt, M.;  Koch, M.;  Schnitzler, H.-U. 

NMDA receptors in the pontine brainstem are necessary for fear potentiation of the startle response
In: European Journal of Pharmacology, Vol. 318, 1996, Issue 1, S. 1-6, 10.1016/S0014-2999(96)00749-2

Fendt, M.;  Koch, M.;  Schnitzler, H.-U. 

Somatostatin in the pontine reticular formation modulates fear potentiation of the acoustic startle response: An anatomical, electrophysiological, and behavioral study
In: Journal of Neuroscience, Vol. 16, 1996, Issue 9, S. 3097-3103

1995

Begutachteter Zeitschriftenartikel
Fendt, M.;  Koch, M.;  Kungel, M.;  Schnitzler, H.-U. 

Cholecystokinin enhances the acoustic startle response in rats
In: NeuroReport, Vol. 6, 1995, Issue 15, S. 2081-2084

1994

Begutachteter Zeitschriftenartikel
Fendt, M.;  Koch, M.;  Schnitzler, H.-U. 

Amygdaloid noradrenaline is involved in the sensitization of the acoustic startle response in rats
In: Pharmacology, Biochemistry and Behavior, Vol. 48, 1994, Issue 2, S. 307-314, 10.1016/0091-3057(94)90532-0

Fendt, M.;  Koch, M.;  Schnitzler, H.-U. 

Lesions of the central gray block the sensitization of the acoustic startle response in rats
In: Brain Research, Vol. 661, 1994, Issue 1-2, S. 163-173, 10.1016/0006-8993(94)91193-2

Fendt, M.;  Koch, M.;  Schnitzler, H.U. 

Sensorimotor gating deficit after lesions of the superior colliculus
In: NeuroReport, Vol. 5, 1994, Issue 14, S. 1725-1728

Kooperationen
  • Prof. Dr. Bertram Geber, Leibniz-Instit für Neurobiologie, Magdeburg
  • Prof. Dr. Michael Koch. Institut für Hirnforschung II (Abteilung Neuropharmakologie), Bremen
  • Dr. Markus Wöhr, Institut für Psychologie, Marburg
  • Prof. Dr. Stephen Liberles, Cell Biology, Harvard Medical School, USA
  • Prof. Dr. Peter J. Flor, Institut für Biologie, Regensburg
  • Prof. Dr. Dr. Yasushi Kiyokawa, Laboratory of Veterinary Ethology, University of Tokyo, Japan
  • Dr. Vegard Brun & Dr. Kirsten Brun Kjelstrup, Department of Clinical Medicine, University of Tromso, Norwegen
  • Dr. Rafa&322; Stryjek, Institute of Psychology, Polish Academy of Sciences, Warschau, Polen
  • Dr. Thomas Endres, Institut für Physiologie, OvGU Magdeburg
  • Prof. Dr. Oliver Stork, Institut für Biologie, OvGU Magdeburg
  • Dr. Xenia Gorny, Institut für Immunologie, OvGU Magdeburg
Profil
Neurobiologie angeborener Furcht
Rolle von mGluRs und Neuropeptiden bei erlernter Furcht
Eventlernen: Charakterisierung und neuronale Grundlage
Narkolepsie: Neuronale Grundlage, Bedeutung von Emotionen und potentielle Behandlungsstrategien
Service
Testen von Substanzen in verschiedenen Tierparadigmen für neuropsychiatrische Erkrankungen (Furcht/Angst, Narkolepsie, Schizophrenie, Lernen & Gedächtnis)
Vita
seit 2013         Außerplanmäßigen Professor, Otto-von-Guericke-Universität Magdeburg
2013                Umhabilitierung & Erweiterung Fachbereich"Neuropharmakologie", Otto-von-Guericke-Universität Magdeburg
seit 2012         Arbeitsgruppenleiter am Institut für Pharmakologie und Toxikologie, Otto-von-Guericke-Universität Magdeburg
2006 - 2012    Senior Investigator, Novartis Instituts for BioMedical Research, Neuropsychiatry, Basel
2006 - 2012    Außerplanmäßigen Professor, Fakultät für Biologie, Eberhard-Karls-Universität Tübingen
2002                Habilitation und Venia legendi, Fachbereich "Tierphysiologie", Eberhard-Karls-Universität Tübingen
1999 - 2006    Arbeitsgruppenleiter am Lehrstuhl Tierphysiologie, Eberhard-Karls-Universität Tübingen
1997 - 1999    Postdoktorand Universität Tübingen, Forschungsaufenthalt an der Yale University, USA
1993 - 1997    Doktorarbeit, Betreuer: Michael Koch & Hans-Ulrich Schnitzler, Lehrstuhl Tierphysiologie, Universität Tübingen
1987 - 1993    Studium der Biologie/Diplom. Hauptfach Tierphysiologie, Nebenfächer Humangenetik, Botanik & physiol. Psychologie
presse

Letzte Änderung: 28.08.2017 - Ansprechpartner:

Sie können eine Nachricht versenden an: Webmaster
Sicherheitsabfrage:
Captcha
 
Lösung: