Prof. Zenclussen

Prof. Dr. rer. nat. Ana Claudia Zenclussen
Universitätsfrauenklinik (KGYN/UFK)
Aktuelle Projekte
- Kälteschockproteine in der Reproduktion: Relevanz der Expression von Trophoblast-spezifischen YB-1 für die Entwicklung des Embryos
Laufzeit: 01.11.2018 - 31.10.2021
Abgeschlossene Projekte
- Einfluss von Mastzellen und ihren Mediatoren auf das Wachstum und die Entwicklung von Ovarialtumoren
Laufzeit: 01.12.2016 - 30.11.2018 - Untersuchung der protektiven HO-1-assoziierten Mechanismen bei der Implantation, Plazentation und den fötalen Wachstum im Mausmodell und anhand von in vitro Modellen. Beteiligung von Kohlenmonoxid bei der Vorbereitung eines optimalen uterinen Mikromilieu
Laufzeit: 01.11.2015 - 31.10.2018 - Unraveling the molecular mechanisms of B-cell associated IL-10 protective effects in pre-term delivery.
Laufzeit: 01.11.2015 - 31.10.2018 - Einfluss von Umweltöstrogenen auf endokrine Faktoren, die während der Schwangerschaft die Immunantwort modulieren
Laufzeit: 01.09.2016 - 31.08.2018 - Mast cells as critical regulators of tissue remodeling during implantation an placentation mechanisms of action and
Laufzeit: 01.07.2012 - 30.04.2017 - Teilprojekt 3: Uterines inflammatorisches Mikromilieu nach Chlamydien-Infektion als Risiko für Zervix-karzinom: Rolle von Hämoxygenase-1 und therapeutische Möglichkeiten im Mausmodell
Laufzeit: 01.02.2014 - 01.02.2017 - Expressionsregulation von Y-P30 in maternalen T-Zellen und ihr Einfluss auf die Neuritogenese thalamischer/kortikaler Neurone
Laufzeit: 01.01.2010 - 31.12.2013 - B-1a B Zellen in Präeklampsie
Laufzeit: 01.08.2012 - 31.10.2013 - Immunologische Toleranz beim Neuroblastom als Grundlage für die Entwicklung neuer immuntherapeutischer Ansätze (in Kooperation mit Dr. Stefan Fest Pädiatrische Immuntherapie)
Laufzeit: 01.01.2010 - 31.12.2012 - Humanes Choriongonadotropin und Luteinisierendes Hormon als Chemoattraktoren von regulatorischen T-Zellen in der Schwangerschaft
Laufzeit: 15.04.2010 - 14.10.2012 - Mast cells as novel regulators of tolerance at the fetal-maternal interface: their role in pregnancy success as "Treg-helpers" and study of their therapeutic potential in spontaneous abortions
Laufzeit: 01.10.2009 - 30.09.2012 - Herbstschule 2011: Reproduktionsbiologie und -immunologie
Laufzeit: 01.08.2011 - 31.10.2011 - Characterization of tolerance mechanisms at the fetal-maternal interface - Treg cells and novel tolerance-related molecules
Laufzeit: 01.10.2009 - 31.12.2010 - Participation of mast cells in regulatory T cells (Treg)-induced tolerance at the fetal-maternal interface: Consequences of mast cells or mast cell-related genes absence in pregnancy outcome
Laufzeit: 01.08.2008 - 31.08.2010 - Reprogrammierung der Toleranz in murinen Modellen immunologischer Schwangerschaftskomplikationen mittels regulatorischer T-Zellen
Laufzeit: 24.05.2005 - 01.02.2010 - Study of the therapeutic potential of CO during implantation in a mouse model of spontaneous abortion
Laufzeit: 01.10.2007 - 30.09.2009 - Study of the therapeutic potential of HO-1 and its metabolite CO in avoiding immunological fetal rejection in murine models of pregnancy complications
Laufzeit: 01.07.2006 - 30.12.2008 - Vorsetzungsantrag: Reprogrammierung der Toleranz in murinen Modellen immunologischer Schwangerschaftskomplikationen mittels regulatorischer T-Zellen II
Laufzeit: 01.12.2007 - 30.11.2008
2020
Abstract
Human chorionic gonadotropin acts as a central regulator of adaptive immune responses during early pregnancy safeguarding fetal survival
In: The journal of immunology - Bethesda, Md.: Soc., 1916, Vol. 204.2020, Suppl. 1, 235.17
Begutachteter Zeitschriftenartikel
A checkpoint cliffhanger at the dawn of placental mammals
In: The journal of biological chemistry - Bethesda, Md.: Soc., 1905, Bd. 295.2020, 14, S. 4381-4382
Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice
In: Archives of toxicology: official journal of EUROTOX - Berlin: Springer, 1930, Bd. 94.2020, 8, S. 2847-2859
Heme oxygenase-1 is a pivotal modulator of bone turnover and remodeling - molecular implications for prostate cancer bone metastasis
In: Antioxidants & redox signaling: ARS - Larchmont, NY: Liebert, 1999, Bd. 32.2020, 17, S. 1243-1258
Immune cells in the uterine remodeling - are they the target of endocrine disrupting chemicals?
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Vol. 11.2020, Art.-Nr. 246, insgesamt 15 Seiten
Innate and adaptive immune responses in HELLP syndrome
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Vol. 11.2020, Art.-Nr. 667, insgesamt 10 Seiten
Plasma membrane Ca2+ ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca2+ homeostasis in mice
In: European journal of immunology - Weinheim: Wiley-VCH, 1971, Bd. 50.2020, insges. 9 S.
Regulatory B cells are decreased and impaired in their function in peripheral maternasl blood in pre-term birth
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Vol. 11.2020, Art.-Nr. 386, insgesamt 10 Seiten
Using ultrasound to define the time point of intrauterine growth retardation in a mouse model of heme oxygenase-1 deficiency
In: Biology of reproduction: official journal of the Society for the Study of Reproduction - Cary, NC: Oxford University Press, 1969, Bd. 103.2020, 1, S. 126-134
Y-box binding protein 1 expression in trophoblast cells promotes fetal and placental development
In: Cells: open access journal - Basel: MDPI, 2012, Vol. 9.2020, 9, Art.-Nr. 1942, insgesamt 16 Seiten
c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, Bd.11.2020, Art.-Nr. 1056, insgesamt 16 Seiten
2019
Abstract
Impaired B cell-specific LPS-signaling culminates in infection-induced preterm birth via decreased IL-10 expression
In: European journal of immunology - Weinheim: Wiley-VCH, Bd. 49.2019, Suppl. 1, P7, Seite 77-78
Mast cells influence ovarian tumor growth in vitro and in vivo
In: European journal of immunology - Weinheim: Wiley-VCH, Bd. 49.2019, Suppl. 1, P184, Seite 167-168
Selective depletion of regulatory T cells suppressed neuroblastoma tumor growth in mice
In: Cancer research - Philadelphia, Pa: AACR, Vol. 79.2019, 13, Suppl., Abs. 4570, insges. 2 S.
Begutachteter Zeitschriftenartikel
Chymase-Cre; Mcl-1fl/fl mice exhibit reduced numbers of mucosal mast cells
In: Frontiers in immunology - Lausanne: Frontiers Media, Bd. 10.2019, Art.-Nr. 2399, insges. 10 S.
Exposure to 17α-ethinyl estradiol during early pregnancy affects fetal growth and survival in mice
In: Environmental pollution - Amsterdam [u.a.]: Elsevier Science, Bd. 251.2019, S. 493-501
Human chorionic gonadotropin-mediated immune responses that facilitate embryo implantation and placentation
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 10.2019, Art.-Nr. 2896, insges. 14 S.
Human miscarriage is associated with dysregulations in peripheral blood-derived myeloid dendritic cell subsets
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 10.2019, Art.-Nr. 2440, insges. 12 S.
IL-10 producing B cells rescue mouse fetuses from inflammation-driven fetal death and are able to modulate T cell immune responses
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 9.2019, Art.-Nr. 9335, insges. 10 S.
Mast cells as protectors of health
In: The journal of allergy and clinical immunology - Amsterdam [u.a.]: Elsevier, Bd.144.2019, 4 Suppl., S. S4-S18
The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures
In: Toxicology letters - Amsterdam [u.a.]: Elsevier Science, Bd. 303.2019, S. 48-54
2018
Begutachteter Zeitschriftenartikel
Bisphenol A exposure during early pregnancy impairs uterine spiral artery remodeling and provokes intrauterine growth restriction in mice
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 8.2018, Art.-Nr. 9196, insges. 10 S.
Cold shock Y-box binding protein-1 acetylation status in monocytes is associated with systemic inflammation and vascular damage
In: Atherosclerosis - Amsterdam [u.a.]: Elsevier Science, Bd. 278.2018, S. 156-165
High frequency ultrasound for the analysis of fetal and placental development in vivo
In: JoVE - [S.l.], 2018, 141, Art.-Nr. e58616
Immune cells at the fetomaternal interface - how the microenvironment modulates immune cells to foster fetal development
In: The journal of immunology - Bethesda, Md.: Soc., Bd. 201.2018, 2, S. 325-334
In situ detection of CD73+ CD90+ CD105+ lineage - mesenchymal stromal cells in human placenta and bone marrow specimens by chipcytometry
In: Cytometry / A - Hoboken, NJ: Wiley-Liss, Bd. 93.2018, 9, S. 889-893
Mast cells - good guys with a bad image?
In: American journal of reproductive immunology - Oxford: Wiley Blackwell, Bd. 80.2018, 4, Art.-Nr. e13002
Plasma cell alloantigen 1 and IL-10 secretion define two distinct peritoneal B1a B cell subsets with opposite functions, PC1high cells being protective and PC1low cells harmful for the growing fetus
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 9.2018, Art.-Nr. 1045, insges. 10 S.
Simultaneous ablation of uterine natural killer cells and uterine mast cells in mice leads to poor vascularization and abnormal Doppler measurements that compromise fetal well-being
In: Frontiers in immunology - Lausanne: Frontiers Media, Bd. 8.2018, Article 1913 insges. 8 S.
The pregnancy hormone human chorionic gonadotropin differentially regulates plasmacytoid and myeloid blood dendritic cell subsets
In: American journal of reproductive immunology: official journal of the American Society for Reproductive Immunology - Oxford: Wiley Blackwell, 1980, Bd. 79.2018, 4, Art.-Nr. e12837
Dissertation
Einfluss von Hypoxie und Differenzierung auf CX43, Gap-Junctions und Gap-Junction-vermittelte Kommunikation in Monozyten und Makrophagen
In: Magdeburg: Otto-von-Guericke-Universität Magdeburg, 2018, verschiedene Seitenzählung, Illustrationen, Diagramme
Welcher mikrobielle, vaginale Fingerabdruck gehört zu einer gesunden, Vaginose-freien Schwangerschaft? - Anwendung des Terminalen Restriktionsfragmentlängenpolymorphismus (T-RFLP)
In: Magdeburg: Otto-von-Guericke-Universität Magdeburg, 2018, 7 ungezählte Blätter, 66 Blätter, Diagramme
2017
Abstract
B cells play an important role in the protection against infection-induced preterm birth
In: European journal of immunology - Weinheim: Wiley VCH, 1971, Bd. 47.2017, Suppl. 2, P45, S. 104
Galectin-1 modulates CD8+T cell response towards tolerance and can be targeted by DNA vaccine to suppress tumor growth in murine neuroblastoma
In: European journal of immunology - Weinheim: Wiley VCH, 1971, Bd. 47.2017, Suppl. 2, P473, S. 315
IL-10 producing B cells protect against LPS-induced intrauterine fetal death in B cell deficient mice
In: European journal of immunology - Weinheim: Wiley VCH, 1971, Bd. 47.2017, Suppl. 2, P44, S. 103
Begutachteter Zeitschriftenartikel
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, 8(2017) Artikel-Nummer 311, 16 Seiten
Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 7.2017, Art.-Nr. 45106, insges. 14 S.
GPER promoter methylation controls GPER expression in breast cancer patients
In: Cancer investigation - Abingdon: Taylor & Francis Group, 1983, Bd. 35.2017, 2, S. 100-107
Progesterone-driven local regulatory T cell induction does not prevent fetal loss in the CBA/J×DBA/2J abortion-prone model
In: American journal of reproductive immunology: official journal of the American Society for Reproductive Immunology - Oxford: Wiley Blackwell, Bd. 77.2017, 3, Art.-Nr. e12626
Safeguarding of fetal growth by mast cells and natural killer cells - deficiency of one is counterbalanced by the other
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 8.2017, Art.-Nr. 711, insges. 10 S.
p45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction
In: Cell death & disease - London [u.a.]: Nature Publishing Group, 2010, Bd. 8.2017, Art.-Nr. e2730, insges. 12 S.
Dissertation
Der G-Protein gekoppelte Östrogenrezeptor als Tumorsuppressor im Mammakarzinom
In: Magdeburg, 2016, VII, 128 Blätter, Illustrationen ; [Literaturverzeichnis: Blatt 107-122]
Habilitation
Toleranz-assoziierte Mechanismen der hormonellen Steuerung von Immunantworten in der Schwangerschaft
In: Magdeburg, 2017, 1 Band (verschiedene Seitenzählungen), Illustrationen, Diagramme
2016
Abstract
Gesteigerte Hämoxygenase-1-Expression in zervikalen Dysplasien und dem Zervixkarzinom
In: Geburtshilfe und Frauenheilkunde - Stuttgart: Thieme, 1980, Bd. 76.2016, 10, Abs. P136, insges. 1 S.
Begutachteter Zeitschriftenartikel
A Jacob/Nsmf gene knockout results in hippocampal dysplasia and impaired BDNF signaling in dendritogenesis
In: PLoS Genetics: a peer-reviewed, open-access journal/ Public Library of Science - San Francisco, Calif.: Public Library of Science, 2005, Bd. 12.2016, 3, Art.-Nr. e1005907, insges. 32 S.
Human umbilical vein endothelial cells foster conversion of CD4+CD25 Foxp3 T cells into CD4+Foxp3+ regulatory T cells via transforming growth factor-[beta]
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 6, 2016, Art.-Nr. 23278, insges. 8 S.
Immune modulatory effects of human chorionic gonadotropin on dendritic cells supporting fetal survival in murine pregnancy
In: Frontiers in endocrinology - Lausanne: Frontiers Research Foundation, 2010, Bd. 7.2016, Art.-Nr. 146, insges. 11 S.
JEG-3 trophoblast cells producing human Chorionic Gonadotropin promote conversion of human CD4+FOXP3- T cells into CD4+FOXP3+ Regulatory T cells and foster T cell suppressive activity
In: Biology of reproduction: official journal of the Society for the Study of Reproduction - Cary, NC: Oxford University Press, 1969, Bd. 94.2016, 5, Art.-Nr. 106, insges. 11 S.
Maternal and fetal mechanisms of B cell regulation during pregnancy - human Chorionic Gonadotropin stimulates B cells to produce IL-10 while alpha-fetoprotein drives them into apoptosis
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 7.2016, Art.-Nr. 495, insges. 13 S.
Maternal extracellular vesicles and platelets promote preeclampsia through inflammasome activation in trophoblasts
In: Blood - Washington, DC: American Society of Hematology, 1946, Bd. 128.2016, 17, S. 2153-2164
Placental immune editing switch (PIES) - learning about immunomodulatory pathways from a unique case report
In: OncoTarget - [S.l.]: Impact Journals LLC, 2010, Bd. 7.2016, 50, S. 83817-83827
Targeting of heme oxygenase-1 as a novel immune regulator of neuroblastoma
In: International journal of cancer: publication of the International Union against Cancer (UICC) - Bognor Regis: Wiley-Liss, 1966, Bd. 138.2016, 8, S. 2030-2042
Dissertation
Die Beteiligung von uterinen Mastzellen und uterinen Natürlichen Killerzellen an einer erfolgreichen Schwangerschaft und einer gesunden Entwicklung des Fetus
In: Magdeburg, 2016, X, 146 Blätter, Illustrationen ; [Literaturverzeichnis: Blatt 125-140]
Die regulatorische Funktion von HO-1 auf uterine NK Zellen an der feto-maternalen Grenzfläche
In: Magdeburg, 2016, 141 Blätter, Illustrationen ; [Literaturverzeichnis: Blatt 126-137]
2015
Abstract
Mechanism of the increased thrombosis risk induced by blood loss during caesarian section
In: Journal of thrombosis and haemostasis: the official journal of the International Society on Thrombosis and Haemostasis ; JTH - Oxford: Blackwell, 2003, Bd. 13.2015, Suppl. 2, PO518-MON, S. 449
Regulation of immune tolerance during pregnancy
In: Placenta - Amsterdam [u.a.]: Elsevier, 1980, Bd. 36.2015, 4, Abs. S6., S. 478
Role of p45-NF-E2 in regulating syncytiotrophoblast formation in human placenta
In: Thrombosis research: an international journal on vascular obstruction, hemorrhage and hemostasis - Amsterdam: Elsevier, 1972, Vol. 35.2015, Suppl. 1, OC-3a, S. S66
Begutachteter Zeitschriftenartikel
Cellular regulation of the uterine microenvironment that enables embryo implantation
In: Frontiers in immunology - Lausanne: Frontiers Media, Bd. 6.2015, Art.-Nr. 321, insges. 12 S.
Effects of heme oxygenase-1 on innate and adaptive immune responses promoting pregnancy success and allograft tolerance
In: Frontiers in pharmacology - Lausanne: Frontiers Media, 2010, Bd. 5.2015, Art.-Nr. 288, insges. 9 S.
Heme oxygenase-1 is critically involved in placentation, spiral artery remodeling, and blood pressure regulation during murine pregnancy
In: Frontiers in pharmacology - Lausanne: Frontiers Media, Bd. 5.2015, Art.-Nr. 291, insges. 10 S.
Heme oxygenases: novel regulators of reproductive processes. Editorial
In: Frontiers in pharmacology - Lausanne: Frontiers Media, 2010, Bd. 6.2015, Art.-Nr. 282, insges. 3 S.
Low molecular weight heparin modulates maternal immune response in pregnant women and mice with thrombophilia
In: American journal of reproductive immunology - Oxford: Wiley Blackwell, 1980, Bd. 73.2015, 5, S. 417-427
Transfer of regulatory T cells into abortion-prone mice promotes the expansion of uterine mast cells and normalizes early pregnancy angiogenesis
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 5.2015, Art.-Nr. 13938, insges. 10 S.
Buchbeitrag
The paternal contribution to fetal tolerance
In: The male role in pregnancy loss and embryo implantation failure - Cham [u.a.]: Springer, 2015; Bronson, Richard . - 2015, S. 211-225
2014
Abstract
Epidermal cFLIP regulates skin homeostasis and protects adult skin from TNF-induced keratinocyte apoptosis - beneficial effect of TNF-R2-Fc
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 23.2014, 3, P052, S. e10
GPER-1 acts as a tumor suppressor in ovarian cancer
In: Oncology research and treatment - Basel: Karger, 2014, Bd. 37.2014, Suppl. 1, ID273, S. 71
Begutachteter Zeitschriftenartikel
Analysis of Y-P30/Dermcidin expression and properties of the Y-P30 peptide
In: BMC Research Notes. - London; Bd. 7.2014, Art.-Nr. 400, insges. 12 S.
B cell development undergoes profound modifications and adaptations during pregnancy in mice
In: Biology of reproduction - Cary, NC: Oxford University Press, 1969, Bd. 91.2014, 5, Art.-Nr.115, insges. 11 S.
B cells - the old new players in reproductive immunology
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 5.2014, Art.-Nr. 285, insges. 10 S.
B-1a B cells regulate T cell differentiation associated with pregnancy disturbances
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 5.2014, Art.-Nr.6, insges. 8 S.
Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 9.2014, 2, Art.-Nr.e85924, insges. 11 S.
Carbon monoxide promotes proliferation of uterine natural killer cells and remodeling of spiral arteries in pregnant hypertensive heme oxygenase-1 mutant mice
In: Hypertension - Baltimore, Md: Williams & Wilkins, 1979, Bd. 63.2014, 3, S. 580-588
Endocrine factors modulating immune responses in pregnancy
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 5.2014, Art.-Nr. 196, insges. 12 S.
GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells
In: Journal of cancer research and clinical oncology - Berlin: Springer, 1904, Bd. 140.2014, 4, S. 663-671
GPER functions as a tumor suppressor in triple-negative breast cancer cells
In: Journal of cancer research and clinical oncology - Berlin: Springer, 1904, Bd. 140.2014, 5, S. 713-723
Hormonal fluctuations during the estrous cycle modulate heme oxygenase-1 expression in the uterus
In: Frontiers in endocrinology. - Lausanne : Frontiers Research Foundation; Bd. 5.2014, Art.-Nr. 32, insges. 6 S.
How cells of the immune system prepare the endometrium for implantation
In: Seminars in reproductive medicine - New York, NY: Thieme Medical Publ, 1983, Bd. 32.2014, 5, S. 358-364
In vivo visualization of uterine mast cells by 2-photon microscopy
In: Reproduction - Bristol: BioScientifica, 2001, Bd. 147.2014, 6, S. 781-788
Luteinizing hormone contributes to fetal tolerance by regulating adaptive immune responses
In: American journal of reproductive immunology - Oxford: Wiley Blackwell, 1980, Bd. 71.2014, 5, S. 434-440
Mast cell-mediated and associated disorders in pregnancy - a risky game with an uncertain outcome?
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 5.2014, Art.-Nr. 231, insges. 9 S.
Regulatory T cells: regulators of life
In: American journal of reproductive immunology - Oxford: Wiley Blackwell, 1980, Bd. 72.2014, 2, S. 158-170
2013
Abstract
Epidermal cFLIP is a critical regulator of skin homeostasis and protects embryonic development in mice
In: Experimental dermatology. - Oxford : Wiley-Blackwell; Bd. 22.2013, 3, S. e8
Epidermal cFLIP is a critical regulator of skin homeostasis and protects from TNF-induced keratinocyte apoptosis
In: The journal of investigative dermatology. - New York, NY : Nature Publishing Group; Bd. 133.2013, Suppl. 1, Abs.187, S. S32
Human chorionic gonadotropin and luteinizing hormone, but not progesterone, contribute to the initiation of a tolerogenic immune response in pregnancy
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 190.2013, Suppl., 124.19, insges. 1 S.
Pregnancy establishment is influenced by CCR7 and CCR9 (P6360)
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 190.2013, Suppl., 199.6, insges. 1 S.
Begutachteter Zeitschriftenartikel
Adaptive immune responses during pregnancy
In: American journal of reproductive immunology. - Oxford : Wiley-Blackwell, Bd. 69.2013, 4, S. 291-303
Control of uterine microenvironment by Foxp3+ cells facilitates embryo implantation
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 4.2013, Art.-Nr. 158, insges. 12 S.
Cutting edge: IL-10-producing regulatory B cells in early human pregnancy
In: American journal of reproductive immunology - Oxford: Wiley Blackwell, 1980, Bd. 70.2013, 6, S. 448-453
GPER-1 acts as a tumor suppressor in ovarian cancer
In: Journal of ovarian research: JOR - London: BioMed Central, 2008, Bd. 6.2013, Art.-Nr. 51, insges. 10 S.
HO-1 as modulator of the innate immune response in pregnancy
In: American journal of reproductive immunology - Oxford: Wiley Blackwell, 1980, Bd. 70.2013, 1, S. 24-30
Human chorionic gonadotropin as a central regulator of pregnancy immune tolerance
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 190.2013, 6, S. 2650-2658
In vivo multiphoton microscopy technique to reveal the physiology of the mouse uterus
In: American journal of reproductive immunology: AJRI ; official journal of the American Society for Reproductive Immunology - Oxford: Wiley-Blackwell, 1980, Bd. 69.2013, 3, S. 281-289
Mast cells as novel mediators of reproductive processes
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 4.2013, Art. 29, insges. 6 S.
Mast cells rescue implantation defects caused by c-kit deficiency
In: Cell death & disease - London [u.a.]: Nature Publishing Group, 2010, Bd. 4.2013, Art.-Nr. e462, insges. 11 S.
Origin of Foxp3+ cells during pregnancy
In: American journal of clinical and experimental immunology - Madison, Wis: e-Century Publ, 2012, Bd. 2.2013, 3, S. 222-233
Regulatory B10 cells restore pregnancy tolerance in a mouse model
In: Biology of reproduction - Cary, NC: Oxford University Press, 1969, Bd. 89.2013, 4, Art.-Nr. 90, S. 1-7
Regulatory T cells are baby's best friends
In: American journal of reproductive immunology: AJRI ; official journal of the American Society for Reproductive Immunology - Oxford: Wiley-Blackwell, 1980, Bd. 69.2013, 4, S. 331-339
Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma
In: Cancer letters - Amsterdam [u.a.]: Elsevier Science, 1975, Bd. 331.2013, 2, S. 167-173
The role of B cells in pregnancy: the good and the bad
In: American journal of reproductive immunology: AJRI ; official journal of the American Society for Reproductive Immunology - Oxford: Wiley-Blackwell, 1980, Bd. 69.2013, 4, S. 408-412
cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis
In: Cell reports. - Maryland Heights, MO : Cell Press, Bd. 5.2013, 2, S. 397-408
2012
Originalartikel in begutachteter internationaler Zeitschrift
Blockage of Heme oxygenase-1 abrogates the protective effect of regulatory T cells on murine pregnancy and promotes the maturation of dendritic cells
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 7, 2012, 8 Art.e42301, insges.13 S.
CD19+CD5+ cells as indicators of preeclampsia
In: Hypertension - Baltimore, Md: Lippincott Williams & Wilkins, 1952, Bd. 59.2012, 4, S. 861-868
Exploring the potential of low doses carbon monoxide as therapy in pregnancy complications
In: Medical Gas Research - London: BioMed Central, 2011, Bd. 2, 2012, Art.4, insges.10 S.
Heme oxygenase-1 expression in the ovary dictates a proper oocyte ovulation, fertilization, and corpora lutea maintenance
In: American journal of reproductive immunology. - Oxford : Wiley-Blackwell, Bd. 67.2012, 5, S. 376-382
In vivo multiphoton microscopy technique to reveal the physiology of the mouse placenta
In: American journal of reproductive immunology. - Oxford : Wiley-Blackwell, Bd. 68.2012, 3, S. 271-278
Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments
In: International journal of cancer: IJC / International Union against Cancer: IJC - Malden, Mass.: Wiley-Blackwell, 1966, Bd. 131.2012, 5, S. 1131-1141
Role of female sex hormones, estradiol and progesterone, in mast cell behavior
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 3, 2012, Art.169, insges.4 S.
Study of the uterine local immune response in a murine model of embryonic death due to tritrichomonas foetus
In: American journal of reproductive immunology: AJRI ; official journal of the American Society for Reproductive Immunology - Oxford: Wiley-Blackwell, 1980, Bd. 68.2012, 2, S. 128-137
2011
Dissertation
Immunhistologische Untersuchungen an Ovarbiopsien von Frauen mit Ovarialfunktionsstörungen
In: Magdeburg, Univ., Med. Fak., Diss., 2011; 80 Bl: Ill., graph. Darst
SDF-1/CXCR4-dependet effects of tissue resident stem cells on breast cancer development
In: Magdeburg, Univ., Med. Fak., Diss., 2011; 94 Bl: Ill., graph. Darst
Originalartikel in begutachteter internationaler Zeitschrift
Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide
In: The journal of pathology. - Chichester [u.a.] : Wiley, Bd. 225.2011, 2, S. 293-304
2010
Originalartikel in begutachteter internationaler Zeitschrift
Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 5, 2010, 12, Art.e14409, insges.12 S.
Regulatory T cells and their role in pregnancy
In: American journal of reproductive immunology: AJRI ; official journal of the American Society for Reproductive Immunology - Oxford: Wiley-Blackwell, 1980, Bd. 63.2010, 6, S. 445-459
The implication of aberrant GM-CSF expression in decidual cells in the pathogenesis of preeclampsia
In: The American journal of pathology: cellular and molecular biology of disease ; official publication of the American Society for Investigative Pathology - New York, NY [u.a.]: Elsevier, 1925, Bd. 177.2010, 5, S. 2472-2482
The persistence of paternal antigens in the maternal body is involved in regulatory T-cell expansion and fetal-maternal tolerance in murine pregnancy
In: American journal of reproductive immunology . - Oxford : Wiley-Blackwell, Bd. 63.2010, 3, S. 200-208
Originalartikel in begutachteter zeitschriftenartiger Reihe
Pregnancy: tolerance and suppression of immune responses
In: Suppression and regulation of immune responses: methods and protocols / ed. by Maria Christina Cuturi and Ignacio Anegon: methods and protocols - New York, NY [u.a.]: Humana Press [u.a.], 2010; Cuturi, Maria Cristina . - 2010, S. 397-417
2009
Originalartikel in begutachteter internationaler Zeitschrift
Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 182.2009, 9, S. 5488-5497
PD-1 but not CTLA-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model
In: American journal of reproductive immunology. - Oxford : Wiley-Blackwell, Bd. 62.2009, 5, S. 283-292
Survivin minigene DNA vaccination is effective against neuroblastoma
In: International journal of cancer: IJC / International Union against Cancer: IJC - Malden, Mass.: Wiley-Blackwell, 1966, Bd. 125.2009, 1, S. 104-114
2008
Originalartikel in begutachteter internationaler Zeitschrift
Mechanisms behind flare of renal lupus during murine pregnancy
In: Reproductive biomedicine online . - Oxford : Elsevier, Bd. 17.2008, 1, S. 114-126
Novel Role for Inhibitor of Differentiation 2 in the Genesis of Angiotensin IIInduced Hypertension
In: Circulation May 20;117(20):2645-56.
Supporting the hypothesis of pregnancy as a tumor: survivin is upregulated in normal pregnant mice and participates in human trophoblast proliferation
In: American journal of reproductive immunology. - Oxford : Wiley-Blackwell, Bd. 59.2008, 1, S. 75-83
Supporting the hypothesis of pregnancy as a tumor: survivin is upregulated in normal pregnant mice and participates in human trophoblast proliferation.
In: Am J Reprod Immunol. 2008 Jan;59(1):75-83.
2007
Originalartikel in begutachteter internationaler Zeitschrift
Immunology of pregnancy: cellular mechanisms allowing fetal survival within the maternal uterus.
In: Expert Rev Mol Med. 2007 Apr 27;9(10):1-14. Review.
Kinetics of regulatory T cells during murine pregnancy
In: American journal of reproductive immunology: AJRI ; official journal of the American Society for Reproductive Immunology - Oxford: Wiley-Blackwell, 1980, Bd. 58.2007, 6, S. 514-523
Mechanisms of action of regulatory T cells specific for paternal antigens during pregnancy
In: Obstetrics & gynecology / American College of Obstetricians and Gynecologists - Hagerstown, MD: Wolters Kluwer, 1953, Bd. 110.2007, 5, S. 1137-1145
Murine Pre-Eclampsia Induced by Unspecific Activation of the Immune System Correlates with Alterations in the eNOS and AT1 Receptor Expression in the Kidneys and Placenta.
In: Placenta. 2007 Jul;28(7):688-700. Epub 2006 Nov 28.
Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/LPR mice.
In: 2014,
2006
Originalartikel in begutachteter internationaler Zeitschrift
A novel mouse model for preeclampsia by transferring activated th1 cells into normal pregnant mice.
In: Methods Mol Med. 2006;122:401-12.
Stress and substance P but not the substance P-metabolite SP5-11 trigger murine abortion by augmenting TNF-alpha levels at the feto-maternal interface
In: Scand J Immunol. 2006 Jan;63(1):42-9.
2005
Originalartikel in begutachteter internationaler Zeitschrift
Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+T regulatory cells prevents fetal rejection in a murine abortion model
In: Am J Pathol.
Anti-P- and E-selectin therapy prevents abortion in the CBA/J x DBA/2J combination by blocking the migration of Th1 lymphocytes into the foetal-maternal interface.
In: Cell Immunol. 2005 Dec;238(2):97-102. Epub 2006 Mar 31.
CD4(+)CD25+ T regulatory cells in murine pregnancy.
In: J Reprod Immunol. 2005 Apr;65(2):101-10.
Heme oxygenase as a therapeutic target in immunological pregnancy complications.
In: Int Immunopharmacol. 2005 Jan;5(1):41-51.
Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion.
In: J Reprod Immunol. 2006 Feb;69(1):35-52. Epub 2005 Dec 28.
Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood.
In: Am J Reprod Immunol. 2005 Dec;54(6):384-9.
Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface.
In: J Immunol. 2005 Oct 15;175(8):4875-4885.
Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface.
In: Eur J Immunol. 2006 Jan;36(1):82-94.
Stress and substance P but not the substance P-metabolite SP5-11 trigger murine abortion by augmenting TNF-alpha levels at the feto-maternal interface.
In: Scand J Immunol. 2006 Jan;63(1):42-9.
The use of gene therapy tools in reproductive immunology research.
In: Curr Gene Ther. 2005 Oct;5(5):459-66.
Upregulation of Bcl-2 at the foetal-maternal interface from mice undergoing abortion.
In: Scand J Immunol. 2005 Jun;61(6):492-502.
2004
Originalartikel in begutachteter internationaler Zeitschrift
Human miscarriage is associated with increased number of CD26 decidual lymphocytes.
In: Scand J Immunol. 2004 Apr;59(4):400-7.
Intratumoral infusion of interleukin-1beta and interferon-gamma induces tumor invasion with macrophages and lymphocytes in a rat glioma model.
In: Neurosci Lett. 2004 Jul 8;364(3):145-8.
Introducing a mouse model for pre-eclampsia: adoptive transfer of activated Th1 Cells leads to pre-eclampsia-like symptoms exclusively in pregnant mice
In: Eur J Immunol.
Nerve Growth Factor and its Functional Receptor TrkA are Up-regulated in Murine Decidual Tissue of Stress-triggered and Substance P-mediated Abortion.
In: Am J Reprod Immunol. 2004 Jan;51(1):86-93.
2003
Originalartikel in begutachteter internationaler Zeitschrift
Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies.
In: Am J Reprod Immunol. 2003 Jul;50(1):66-76.
Murine abortion is associated with enhanced interleukin-6 levels at the feto-maternal interface.
In: Cytokine. 2003 Nov 21;24(4):150-60.
Th1 cytokines and the prothrombinase fgl2 in stress-triggered and inflammatory abortion.
In: Am J Reprod Immunol. 2003 Apr;49(4):210-20.
The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response.
In: Steroids. 2003 Nov;68(10-13):931-40.
2002
Originalartikel in begutachteter internationaler Zeitschrift
Heme Oxygenase is Downregulated in Stress-Triggered and Interleukin-12-Mediated Murine Abortion.
In: Scand J Immunol. 2002 Jun;55(6):560-9.
Interleukin regulation of asymmetric antibody synthesized by isolated placental B cells.
In: Am J Reprod Immunol. 2002 Oct;48(4):275-82.
Questioning the Th1/Th2 Paradigm in Reproduction: Peripheral Levels of IL-12 are Down-Regulated in Miscarriage Patients.
In: Am J Reprod Immunol. 2002 Oct;48(4):245-51.
2001
Originalartikel in begutachteter internationaler Zeitschrift
Asymmetric antibodies and pregnancy.
In: Am J Reprod Immunol. 2001 May;45(5):289-94.
During pregnancy, in the context of a Th2-type cytokine profile, serum IL-6 levels might condition the quality of the synthesized antibodies.
In: Am J Reprod Immunol. 2001 Sep;46(3):181-187.
Upregulation of decidual P-selectin expression is associated with an increased number of Th1 cell populations in patients suffering from spontaneous abortions.
In: Cell Immunol. 2001 Nov 1;213(2):94-103.
- Prof. Dr. Ralf Dechend, Experimental and Clinical Research Center, Charit Campus Buch, Berlin, Deutschland.
- Prof. Dr. Dr. Serban-Dan Costa, Direktor der Universitätsfrauenklinik, Universitätsklinikum der Otto-von-Guericke-Universität Magdeburg, Deutschland.
- Prof. Gabriel Rabinovich, Instituto de Biologia y Medicina Expermenta, Universität Cordoba, Argentinien
- Prof. Dr. Marcus Maurer, Charit Berlin - Campus Mitte, Klinik für Dermatologie, Venerologie und Allergologie, Deutschland.
- Prof. Gil Mor, Reproductive Immunology Unit, Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, USA.
- Priv. Doz. Dr. habil Stefan Fest, Universität Leipzig, Zentrales Forschungslabor, Leipzig, Deutschland
- Prof. Dr. Ingo Bechmann, Universität Leipzig, Institut für Anatomie, Deutschland
- Dr. rer. nat. Mario Lorenz, Charit-Universitätsmedizin Berlin, Campus Mitte, Medizinische Klinik für Kardiologie und Angiologie, Deutschland
- Univ.-Lektor Ass.-Prof. Mag. Dr. Jürgen Pollheimer, Dept. of Obstetrics and Fetal-Maternal Medicine, Medical University of Vienna
- apl. Prof. Dr. Atanas Ignatov, Geschäftsführender Oberarzt der Universitätsfrauenklinik, Universitätsklinikum der Otto-von-Guericke-Universität Magdeburg, Deutschland.
Immunologie: Toleranz
Gynäkologie und Geburtshilfe: Experimentelle Gynäkologie, Mausmodelle
Schwangerschaft
Fehlgeburt und Präeklampsie
Toleranzmechanismen in Mausmodellen
Trophoblasten
molekularbiologische und immunologische Methoden wie Immunhistochemie (IHC),
Prof. Dr. Ana Claudia ZENCLUSSEN Abteilungsleiterin: Experimentelle Gynäkologie und Geburtshilfe Universitätsfrauenklinik Magdeburg Gerhart-Hauptmann-Straße 35 | ||
D - 39108 | Magdeburg Tel.: (0391) 67-17460 | |
Fax :(0391) 67-17440 | Stand: Dez 2010 | |
Curriculum Vitae | ||
Geburtsdatum 16. November 1971 | Geburtsort Esperanza, Argentinien Ausbildung und Werdegang | |
1978-1984 | Grundschule "Don José de San Martín", Esperanza, Argentinien | |
1985-1989 | Gymnasium "Escuela Normal Superior Domingo F. Sarmiento" Abschluss: Abitur | |
1990-1996 | Biochemiestudium an der Universität "Universidad Nacional del Litoral", Santa Fe, Argentinien | |
1993-1996 | Wissenschaftliche Hilfskraft am Institut für Zelluläre Biologie der Universität "Universidad Nacional del Litoral", Santa Fe, Argentinien | |
1996-1998 | Wissenschaftliche Mitarbeiterin am Institut für Zelluläre Biologie der Universität "Universidad Nacional del Litoral", Santa Fe | |
1996-2001 | Promotion (PhD, Dr.rer.nat.) an der Universität von Buenos Aires im Bereich Immunologie, unter der Leitung von Herrn Prof. Dr. Ricardo Margni. Abgeschlossen mit "ausgezeichnet" (10). Anerkannt in Deutschland (Juli 2001) | |
2000 | DAAD Stipendiatin am BMFZ, Charité, Humboldt Universität zu Berlin | |
Mai-Oktober 2001 | Post-Doc Wissenschaftliche Mitarbeiterin in der Charité (BAT IIa), Humboldt Universität zu Berlin. | |
Oktober 2001- März 2003 | Gastwissenschaftlerin und Stipendiatin der Alexander von Humboldt Stiftung. Thema: Stress und Präeklampsie, Charité, Humboldt Universität zu Berlin. | |
April 2003-Mai 2007 | Arbeitsgruppenleiterin und wissenschaftliche Mitarbeiterin und am Institut für Medizinische Immunologie (Dir: Prof. Dr. Hans-Dieter Volk), Charité, Humboldt Universität zu Berlin. | |
2004-2006 | Gastprofessorin an der Universidad Nacional del Litoral, Santa Fe, Argentinien. | |
2005 | Antrag auf Habilitationsverfahren (Charité, Medizinische Universität Berlin). | |
Feb. 2006 | Lehrbefugnis. Charité, Universitätsmedizin Berlin. Antrittsvorlesung: 07. Juni 2006. Fach: Immunologie | |
Sept. 2006 | Ruf W2 Professur für Experimentelle Gynäkologie. Otto-von-Guericke Universität, Magdeburg. | |
Okt. 2006 | Ruf W1 Professur für Reproduktive Immunologie. Charité, Medizinische Universität zu Berlin. Ruf abgelehnt | |
Mai 2007 | Universitätsprofessorin (W2, unbefristet) an der Otto-von-Guericke-Universität Magdeburg, Medizinische Fakultät (Experimentelle Gynäkologie und Geburtshilfe mit Schwerpunkt Immunologie). | |
Mai 2007 | Gastwissenschaftlerin am Institut für Medizinische Immunologie (Dir: Prof. Dr. Hans-Dieter Volk), Charité, UniversitätsmedizinGastprofessorin an der Universidad del. Sur, Bahia Blanca, Argentinien | |
Akademische Aktivitäten | ||
2009-2013 | Vorstandsmitglied, SFB 854 | |
Seit 2012 | Vorsitzende der Nachwuchskommission, FME, OvGU, Magdeburg | |
Seit 2012 | Mitglied der Forschungskommission, FME, OvGU, Magdeburg | |
Stipendien | ||
1998-2001 | Forschungsstipendium der FOMEC,Buenos Aires (Doktorarbeit) | |
1999 | Reisestipendium der NIH (Cooperstown, NY,USA) | |
1999 | Reisestipendium der SAI (SociedadArgentina de Inmunología), Punta del Este,Uruguay | |
2000 | Forschungsstipendium der DAAD | |
2000 | Reisestipendium der American Society for Reproductive Immunology (Jacksonsville, FL, USA) | |
2001 | Reisestipendium der International Society for Reproductive Immunology (Opatija, Kroatien) | |
2001-2002 | Post-Doc Stipendium, Alexander von Humboldt Stiftung | |
2003-2006 | Rahel Hirsch-Habililtationstipendium | |
2005 | Stipendium der Boehringer IngelheimStiftung zum Forschungsaufenthalt in Oeiras,Portugal (Prof. Soares) | |
Preise und Auszeichnungen | ||
2002 | New Investigator Award für: "Introducing a Novel Model for Pre-eclampsia", von: American Society of Reproductive Immunology. Chicago, Juni 2002. | |
2002 | Certificate of Excelence für "Heme Oxygenases (HOs) in pregnancy II¿: HO-2 expression is downregulated in pathologic pregnancy placentas¿, von: American Society of Reproductive Immunology, Chicago, Juni 2002. | |
2004 | Doktoranden der AG (Sollwedel, Zambon Bertoja und Zenclussen ML) erhalten "Young Investigator Award" in Japan (9th International Congress of Reproductive Immunology) | |
2008 | Doktorandin der Abteilung (Leber, geb. Schumacher) erhält Outstanding New Investigator Award der American Society of Reproductive Immunology | |
2009 | PostDoc der Abteilung (Dr. Jensen) bekommt New Investigator Award der International Federation of Placenta Associations. | |
2011 | PostDoc der Abteilung (Dr. Jensen) bekommt New Investigator Travel Award der European Society for Organ Transplantation | |
2011 | Manuskript "Zenclussen et al., Am J Pathol 2005¿ 3. Meistzitierte Artikel von deutschen Wissenschaftlern in der Reproduktionsbiologie (laut Labor Journal) | |
2013 | Paper Schumacher et al., J Immunol 2013, erwähnt als "Research Highlight¿ in Nature Reviews Immunology.eburg | |
Lehre | ||
1994-1998 | Zellularbiologie, Universidad Nacional del Litoral, Santa Fe, Argentinien. | |
1996-1998 | Molekularbiologie, Universidad Nacional del Litoral, Santa Fe, Argentinien | |
2001-2004 | Biochemie, Charité, Charité, Campus Mitte | |
2003-2007 | Immunologie, Charité | |
Seit 2007 | Exp Gynäkologie und Geburtshilfe ; Immunologie. Medizinische Fakultät. Otto-von-Guericke Universität Magdeburg. | |
Seit 2009 | Nicht fakultative Lehrveranstaltung: Seminar und Praktikum: Feto-maternale Biologie und Immunologie. Medizinische Fakultät. Otto-von-Guericke Universität Magdeburg (Blockpraktikum für maximal 20 Studenten) | |
2009 | Postgraduierter intensiver Kurs (2 Wochen). Universidad del Sur, Bahia Blanca, Argentinien |