Research group  „Neuronal and behavioral plasticity“   Leiter: PD Dr. Volker Korz

Objectives:

We are interested in cellular and systemic correlates of memory consolidation. By using hippocampal long-term potentiation (LTP) and –depression (LTD) as cellular, and spatial learning as systemic models  for memory formation, we aim at identifying involved hormones, neurotransmitters and molecular markers.

Projects:

Effects of low and high stress conditions during learning on memory formation and neuronal and synaptic plasticity with special emphasis on roles of adrenal and  gonadal steroid hormones and monoaminergic neurotransmitters

 

Early postnatal stress and epigenetic effects on memory formation and neuronal plasticity during adulthood 

Methods

In vivo-electrophysiology (short and long-term plasticity; long-term potentiation, -depression, EEG)

Spatial training paradigms (holeboard, water maze)

Behavioral and physiological pharmacology

Hormone assays (ELISA; estradiol, testosterone, corticosterone) of brain and blood samples

Microdialysis and HPLC

Head

Dr. Volker Korz

Coworkers

Meyer, Katrin (doctoral  thesis)

Wang, Han (doctoral  thesis)

Selected publications

Korz, V. and Frey, J.U. (2003)

Stress-related modulation of hippocampal long-term potentiation in rats: Involvement of adrenal steroid receptors. J. Neurosci. 23: 7281-7287.

 

Korz, V., Frey, J.U. (2004)

Emotional and cognitive reinforcement of rat hippocampal long term potentiation by different learning paradigms. Neuron Glia Biol. 1, 253-261.

 

Korz, V., Frey, J.U. (2005)

Bidirectional modulation of hippocampal long-term potentiation under stress and no-stress conditions in basolateral amygdala-lesioned and intact rats. J. Neurosci. 25, 7393-7400.

 

Uzakov, S., Frey, J.U., Korz, V. (2005)

Reinforcement of rat hippocampal LTP by holeboard training. Learn. Mem. 12, 165-171.

 

Ahmed, T, Frey, J.U., Korz, V. (2006)

Long-term effects of brief acute stress on cellular signaling and hippocampal LTP. J. Neurosci. 26:3951-3958

 

Korz, V.,  Frey, J.U. (2007)

Hormonal and monoamine signaling during reinforcement of hippocampal long-term potentiation and memory retrieval. Learn. Mem. 14, 160-166.

 

Sajikumar, S., Navakkode, S., Korz, V., Frey, J.U. (2007)

Cognitive and emotional information processing: protein synthesis versus gene expression. J. Physiol. 584.2, 389-400.

 

Gruss, M., Braun, K., Frey, J.U., Korz, V. (2008)

Maternal separation during a specific postnatal time window prevents reinforcement of hippocampal long-term potentiation in adolescent rats. Neuroscience, 152:1-7.

 

Makhracheva-Stepochkina, D., Frey, J.U., Korz, V. (2008)

Spatial learning in the holeboard impairs an early phase of long-term potentiation in the rat hippocampal CA1-region.. Neurobiol. Learn. Mem. 89:545-551.

 

Woldeit, M.L., Korz, V. (2010)

Theta oscillations during holeboard training in rats: Different learning strategies entail different context-dependent modulations in the hippocampus. Neuroscience, 165: 642-653.

 

Schulz, K., Korz, V. (2010)

Emotional and cognitive information processing: relations to behavioral performance and hippocampal long-term potentiation in vivo during a spatial water maze training in rats. Learn. Mem. 17: 552-560.

 

[zurück Abt.Zoologie/Entwicklunsbiologie]