Prof. Reinhold

Prof. Dr. med. Dirk Reinhold
Institut für Molekulare und Klinische Immunologie (IMKI)
Aktuelle Projekte
- "Autonomie im Alter" - "Immuntherapeutika - Entwicklung neuartiger präventiver und/oder therapeutischer Wirkprinzipien zur Minimierung entzündlicher Erkrankungen"
Laufzeit: 01.04.2019 - 31.03.2022
Abgeschlossene Projekte
- "Autonomie im Alter" - Entwicklung neuartiger präventiver und/oder therapeutischer Wirkprinzipien
Laufzeit: 01.01.2016 - 31.03.2019 - Entwicklung eines neuartigen dsDNA-Fluorescence-Linked Immuno-sorbent Assay (FLISA)-Testsystems für die verbesserte Diagnostik systemischer Autoimmunerkrankungen, insbesondere des Systemischen Lupus erythematodes (SLE)
Laufzeit: 01.06.2014 - 31.05.2016 - Entwicklung von spezifischen ELISA-Systemen zur Quantifizierung des Proteins GP2 in Seren von Patienten mit Pankreatitis
Laufzeit: 01.03.2013 - 31.12.2014 - Entwicklung eines automatisierten Zell-Mikropartikel-Kombinationsassays für die Detektion antineutrophiler zytoplasmatischer Antikörper (ANCA) ¿ klinische Validierung und Evaluierung des Kombinationsassys
Laufzeit: 01.01.2011 - 31.12.2012 - IL-16-vermittelte Wirkung von neuen DP IV- und APN-Inhibitoren sowie die Funktion von Th17-Zellen im Tiermodell der Multiplen Sklerose
Laufzeit: 20.01.2009 - 31.12.2011 - Zellbiologische, biochemische und molekular biologische Untersuchungen zur Rolle des Adaptorproteins SKAP HOM bei der Integrim - vermittelten Adhäsion
Laufzeit: 01.10.2005 - 31.05.2009 - In vivo-Untersuchungen zum Wirkmechanismus dualer Inhibitoren der Dipeptidylpeptidase IV (DP IV, CD26) und der Aminopeptidase N (APN, CD13) als Therapie der Multiplen Sklerose
Laufzeit: 21.03.2006 - 31.12.2008 - Untersuchungen zur Bedeutung von Inhibitoren der Dipeptidylpeptidase IV (DP IV) für die Neuroprotektion nach zerebraler Ischämie
Laufzeit: 01.10.2004 - 30.09.2007 - Untersuchungen zur Bedeutung von Inhibitoren der Dipeptidylpeptidase IV (DP IV) und der Aminopeptidase N (APN) für die Therapie und Prävention dermatologischer Erkrankungen mit Hyperproliferation von Fibroblasten
Laufzeit: 01.01.2004 - 31.12.2005 - In vitro- und in vivo-Untersuchungen zur möglichen therapeutischen Anwendung von Inhibitoren der DP IV und der AP N bei der Multiplen Sklerose und der Psoriasis
Laufzeit: 01.01.2001 - 31.12.2003 - Enzymatische Funktion der Dipeptidylpeptidase IV (DP IV, CD26) bei der Regulation der T-Zell-Aktivierung in vitro und in vivo
Laufzeit: 01.01.2001 - 31.12.2003 - Die Rolle von Zytokinen und membranst. Pept. bei Wundheilung
Laufzeit: 01.01.1996 - 31.03.1998
2019
Begutachteter Zeitschriftenartikel
Characterization of mice with a platelet-specific deletion of the adapter molecule ADAP
In: Molecular and cellular biology - Washington, DC: Soc, Bd. 39.2019, 9, Art.-Nr. e00365-18, insges. 16 S.
Immune cell-type specific ablation of adapter protein ADAP differentially modulates EAE
In: Frontiers in immunology - Lausanne: Frontiers Media, Bd. 10.2019, Art.-Nr. 2343, insges. 13 S.
2018
Begutachteter Zeitschriftenartikel
The potential toxic impact of different gadolinium-based contrast agents combined with 7-T MRI on isolated human lymphocytes
In: European radiology experimental - [Cham]: Springer International Publishing, Bd. 2.2018, Art.-Nr. 40, insges. 9 S.
Expression of Zinc transporters ZIP4, ZIP14 and ZnT9 in hepatic carcinogenesis - an immunohistochemical study
In: Journal of trace elements in medicine and biology - München: Elsevier, Bd. 49.2018, S. 35-42
Zinc aspartate suppresses proliferation and Th1/Th2/Th17 cytokine production of pre-activated human T cells in vitro
In: Journal of trace elements in medicine and biology - München: Elsevier, Bd. 49.2018, S. 86-90
Biomarkers of neurodegeneration in autoimmune-mediated encephalitis
In: Frontiers in neurology - Lausanne: Frontiers Research Foundation, Bd. 9.2018, Art.-Nr. 668, insges. 10 S.
CSF macrophage migration inhibitory factor levels did not predict steroid treatment response after optic neuritis in patients with multiple sclerosis
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 13.2018, 11, Art.-Nr. e0207726, insges. 11 S.
Lower serum zinc levels in patients with multiple sclerosis compared to healthy controls
In: Nutrients - Basel: MDPI, Bd. 10.2018, 8, Art.-Nr. 967, insges. 9 S.
Comparison of different immunoassays for γH2AX quantification
In: Journal of laboratory and precision medicine: an open access journal for high-quality research in laboratory medicine : JLPM - Hong Kong: AME Publishing Company, Bd. 3.2018, Art.-Nr. 80, insges. 9 S.
DNA damage assessment and potential applications in laboratory diagnostics and precision medicine
In: Journal of laboratory and precision medicine - Hong Kong: AME Publishing Company, Bd. 3.2018, Art.-Nr. 31, insges. 15 S.
Generation and validation of murine monoclonal and camelid recombinant single domain antibodies specific for human pancreatic glycoprotein 2
In: New biotechnology - New York, NY [u.a.]: Elsevier, Bd. 45.2018, S. 60-68
Phosphorylated histone 2AX foci determination in capillary blood mononuclear cells
In: Journal of laboratory and precision medicine - Hong Kong: AME Publishing Company, Bd. 3.2018, Art.-Nr. 45, insges. 6 S.
ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia
In: Blood - Washington, DC: American Society of Hematology, Bd. 132.2018, 6, S. 635-646
Combined treatment with zinc aspartate and intravenous immunoglobulins (IVIGs) ameliorates experimental autoimmune encephalomyelitis (EAE)
In: Journal of Immunology Research - New York, NY: Hindawi, 2018, Art.-ID 5982169, insges. 7 S.
Antibodies against glycoprotein 2 display diagnostic advantages over ASCA in distinguishing CD from intestinal tuberculosis and intestinal Behçet's disease
In: Clinical and translational gastroenterology - London: Nature Publ. Group, Bd. 9.2018, Art.-Nr. e133, insges. 11 S.
Dissertation
Faktoren einer radiologischen Progression der chronisch progredient verlaufenden rheumatoiden Arthritis
In: Magdeburg: Otto-von-Guericke-Universität Magdeburg, 2018, 72 Blätter, Diagramme
2017
Abstrakt
Clinical symptom tool raises index of suspicion for eosinophilic oesophagitis in adults and drives earlier biopsy for definitive diagnosis
In: Gastroenterology: official publication of the American Gastroenterological Association - Stanford, Calif: HighWire Press, Bd. 152.2017, 5, Suppl. 1, Abs. Tu1094, S. S-859
Insights into the mechanism of action of insulin-like growth factor-1 and insulin in human T cells in vitro
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 26.2017, 3, P081 (OP06/06), S. E35
Insights into the mechanism of action of isotretinoin in human sebocytes in vitro
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 26.2017, 3, P082, S. E35-E36
Gastric cancer in autoimmune gastritis - a casecontrol study from the Star Project on Gastric Cancer Research
In: Gastroenterology: official publication of the American Gastroenterological Association - Stanford, Calif: HighWire Press, Bd. 152.2017, 5, Suppl. 1, Abs. Tu1991, S. S-1028
Magenkarzinom auf dem Boden einer Autoimmungastritis - eine Fall-Kontroll-Studie aus dem staR (gastric cancer research)-Konsortium
In: Zeitschrift für Gastroenterologie: offizielles Organ: Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten mit Sektion Gastroenterologische Endoskopie : Österreichische Gesellschaft für Gastroenterologie und Hepatologie : Ungarische Gesellschaft für Gastroenterologie und Hepatologie - Stuttgart [u.a.]: Thieme, Bd. 55.2017, 8, insges. 1 S.
Begutachteter Zeitschriftenartikel
Clinical symptom tool that raises the index of suspicion for eosinophilic oesophagitis in adults and drives earlier biopsy for definitive diagnosis
In: Alimentary pharmacology & therapeutics - Oxford: Blackwell Science, Bd. 45.2017, 3, S. 417-426
Letter - multivariate clinical model for eosinophilic oesophagitis is this generalisable to a general population? : Authors reply
In: Alimentary pharmacology & therapeutics - Oxford: Blackwell Science, Bd. 45.2017, 6, S. 861
MRI and genetic damage - an update
In: Current radiology reports - New York, NY: Springer, insges. 7 S., 2017
Der neuroimmunologische Boomerang nach Herpes-Simplex-Enzephalitis
In: Klinische Neurophysiologie: Zeitschrift für Funktionsdiagnostik des Nervensystems : EEG, EMG, MEP, Motorik, Elektronystagmographie, Kognitive Prozesse, Schlafstörungen - Stuttgart [u.a.]: Thieme, Bd. 48.2017, 1, S. 44-45
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
In: Nature Communications - [London]: Nature Publishing Group UK, Bd. 8.2017, Artikel-Nummer 311, 16 Seiten
Impact of in vivo high-field-strength and ultra-high-field-strength MR imaging on DNA double-strand-break formation in human lymphocytes
In: Radiology - Oak Brook, Ill: Soc, Bd. 282.2017, 3, S. 782-789
Serological diagnosis and prognosis of severe acute pancreatitis by analysis of serum glycoprotein 2
In: Clinical chemistry and laboratory medicine - Berlin [u.a.]: De Gruyter, Bd. 55.2017, 6, S. 854-864
Autoantibodies against glycoprotein 2 isoforms in pediatric patients with inflammatory bowel disease
In: Inflammatory bowel diseases: official journal of the Crohn\'s & Colitis Foundation of America - Philadelphia, Pa: Lippincott Williams & Wilkins, Bd. 23.2017, 9, S. 1624-1636
Next-generation autoantibody testing by combination of screening and confirmation - the CytoBead® technology
In: Clinical reviews in allergy & immunology - [S.l.]: Springer US, Bd. 53.2017, 1, S. 87-104
2016
Abstrakt
In-vivo-Analyse von DNA-Doppelstrangbrüchen in humanen mononukleären Zellen (MNZ) nach klinischen MRT-Untersuchungen
In: RöFo: Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren - Stuttgart [u.a.]: Thieme, Bd. 188.2016, S01, Abs. WISS307_1, insges. 1 S.
Camelid nanobodies specific to human pancreatic glycoprotein 2
In: The journal of immunology : official journal of the American Association of Immunologists. - Rockville, Md : American Association of Immunologists; Bd. 196.2016, 1 Suppl.,Abs. 209.8, insges. 1 S.
Characterisation of 242 patients with bullous pemphigoid with and without neurological disorder
In: Experimental dermatology : the official journal of the European Immunodermatology Society. - Oxford : Wiley-Blackwell; Bd. 25.2016, 3, P098, S. E17
Begutachteter Zeitschriftenartikel
Serologic anti-GP2 antibodies are associated with genetic polymorphisms, fibrostenosis, and need for surgical resection in Crohn's disease
In: Inflammatory bowel diseases : official journal of the Crohn\'s & Colitis Foundation of America. - Philadelphia, Pa : Lippincott Williams & Wilkins, Bd. 22.2016, 11, S. 2648-2657
DNA double-strand breaks and micronuclei in human blood lymphocytes after repeated whole body exposures to 7T Magnetic Resonance Imaging
In: NeuroImage: a journal of brain function- Orlando, Fla: Academic Press, 1993, Bd. 133.2016, S. 288-293
Simultaneous detection of celiac disease-specific IgA antibodies and total IgA
In: Autoimmunity highlights - Mailand: Springer Milan, Bd. 7.2016, 1, Art.-Nr. 2, insges. 10 S.
The role of zinc in liver cirrhosis
In: Annals of hepatology: the official journal of the Mexican Association of Hepatology - México: Assoc, Bd. 15.2016, 1, S. 7-16
Normal development and function of T cells in proline rich 7 (Prr7) deficient mice
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 11 (2016), 9, Art.-Nr. e0162863, insges. 15 S.
Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness
In: OncoTarget - [S.l.]: Impact Journals LLC, Bd. 7.2016, 33, S. 53797-53807
The mitochondrial phospholipid cardiolipin is involved in the regulation of T-cell proliferation
In: Biochimica et biophysica acta / Molecular and cell biology of lipids - Amsterdam: Elsevier, Bd. 1861.2016, 8 Pt. A, Seite 748-754
Autoimmunity in Crohn's disease - a putative stratification factor of the clinical phenotype
In: Advances in clinical chemistry - New York, NY [u.a.]: Elsevier, Bd. 77.2016, S. 77-101
Cellular analyses in the monitoring of autoimmune diseases
In: Autoimmunity reviews. - Amsterdam [u.a.] : Elsevier Science, Bd. 15.2016, 9, S. 883-889
Oxyntic gastric atrophy in Helicobacter pylori gastritis is distinct from autoimmune gastritis
In: Journal of clinical pathology: JCP : the scientific journal of the Association of Clinical Pathologists - London: BMJ Publ. Group, Bd. 69.2016, 8, S. 677-685
Increased cerebral Tff1 expression in two murine models of neuroinflammation
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 39.2016, 6, S. 2287-2296
2015
Abstrakt
Effects of isotretinoin on FoxO1 transcriptional regulation and molecular functions of SZ95 sebocytes
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 24.2015, 3, P068, S. E12
Oxyntic gastric atrophy in autoimmune gastritis compared to Helicobacter pylori gastritis
In: Helicobacter - Oxford [u.a.]: Wiley-Blackwell, Bd. 20.2015, Suppl. 1, Abs. P01.17, S. 90
Serologische Diagnose der fortgeschrittenen oxyntischen Magenatrophie bei Patienten mit Helicobacter pylori Gastritis und Autoimmungastritis
In: Zeitschrift für Gastroenterologie : offizielles Organ: Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten mit Sektion Gastroenterologische Endoskopie ; Österreichische Gesellschaft für Gastroenterologie und Hepatologie ; Ungarische Gesellschaft für Gastroenterologie und Hepatologie. - Stuttgart [u.a.] : Thieme; Bd. 53.2015, 8, KG019, insges. 1 S.
Begutachteter Zeitschriftenartikel
The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis
In: Critical reviews in immunology - Boca Raton, Fla: CRC Press, Bd. 35.2015, 1, S. 1-14
Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro
In: Molecular and cellular endocrinology - Amsterdam [u.a.]: Elsevier Science, Bd. 415.2015, S. 32-44
Analysis of DNA double-strand breaks and cytotoxicity after 7 Tesla magnetic resonance imaging of isolated human lymphocytes
In: PLOS ONE - San Francisco, California, US: PLOS, Vol. 10.2015, 7, Art. e0132702, insgesamt 14 S.
Assessment of modulated cytostatic drug resistance by automated [gamma]H2AX analysis
In: Cytometry / A - Hoboken, NJ: Wiley-Liss, Bd. 87.2015, 8, S. 724-732
MiR-20a inhibits TCR-mediated signaling and cytokine production in human naïve CD4+ T cells
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 10.2015, 4, Art. e0125311, insges. 17 S.
Autoreactivity to isoforms of glycoprotein 2 in inflammatory bowel disease. Letter to the editor
In: Clinica chimica acta: international journal of clinical chemistry and applied molecular biology - Amsterdam [u.a.]: Elsevier Science, Bd. 442.2015, S. 82-83
Evidence of Crohn's disease-related anti-glycoprotein 2 antibodies in patients with celiac disease
In: Clinical chemistry and laboratory medicine - Berlin [u.a.]: De Gruyter, Bd. 53.2015, 9, S. 1349-1357
Species-specific and pathotype-specific binding of bacteria to zymogen granule membrane glycoprotein 2 (GP2). Postscript
In: Gut: an international journal of gastroenterology and hepatology - London: BMJ Publishing Group, Bd. 64.2015, 3, S. 517-519
Second generation analysis of antinuclear antibody (ANA) by combination of screening and confirmatory testing
In: Clinical chemistry and laboratory medicine - Berlin [u.a.]: De Gruyter, Bd. 53.2015, 12, S. 1991-2002
Der Einfluss des Spurenelements Zink auf das Immunsystem
In: Laboratoriumsmedizin - Berlin [u.a.]: de Gruyter, Bd. 39.2015, 3, S. 135-144
Autoimmune gastritis in autoimmune thyroid disease
In: Alimentary pharmacology & therapeutics - Oxford: Blackwell Science, Bd. 41.2015, 7, S. 686-693
Dissertation
Interleukin 18 als Diagnose- und Verlaufsparameter beim Morbus Still
In: Magdeburg Univ., Med. Fak., Diss., 2015, 91 Bl, Ill., graph. Darst.
Regulation der Interleukin-2-Sekretion in primären humanen T-Lymphozyten durch Cannabinoide
In: Magdeburg Univ., Med. Fak., Diss., 2015, VIII, 77 Bl, Ill., graph. Darst.
2014
Abstrakt
Autoantibodies to glycoprotein 2 are associated with the clinical phenotype in Crohn's disease
In: Zeitschrift für Gastroenterologie: offizielles Organ: Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten mit Sektion Gastroenterologische Endoskopie : Österreichische Gesellschaft für Gastroenterologie und Hepatologie : Ungarische Gesellschaft für Gastroenterologie und Hepatologie - Stuttgart [u.a.]: Thieme, Bd. 52.2014, Nr. 8, FV13, insges. 1 S.
Begutachteter Zeitschriftenartikel
Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation
In: Cell communication and signaling - London: Biomed Central, Bd. 12.2014, Art.-Nr. 74, insges. 8 S.
Treatment of severe autoimmune blistering skin diseases with combination of protein A immunoadsorption and rituximab - a protocol without initial high dose or pulse steroid medication
In: Journal of the European Academy of Dermatology and Venereology. - Oxford [u.a.] : Wiley-Blackwell, Bd. 28.2014, 6, S. 771-780
DPP4-directed therapeutic strategies for MERS-CoV. Correspondence
In: The lancet. - New York, NY : ElsevierThe lancet <London> / Infectious diseases, Bd. 14.2014, 2, S. 100-101
Crohnʾs disease specific pancreatic antibodies - clinical and pathophysiological challenges
In: Clinical chemistry and laboratory medicine. - Berlin [u.a.] : De Gruyter, Bd. 52.2014, 4, S. 483-494
Digital immunofluorescence enables automated detection of antinuclear antibody endpoint titers avoiding serial dilution
In: Clinical chemistry and laboratory medicine. - Berlin [u.a.] : De Gruyter; Bd. 52.2014, 2, S. e9-e11
Oral zinc aspartate treats experimental autoimmune encephalomyelitis
In: BioMetals - Dordrecht [u.a.]: Springer Science + Business Media B.V, Bd. 27.2014, 6, S. 1249-1262
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 9.2014, 9, Art.-Nr. e107743, insges. 11 S.
Expression analysis of zinc transporters in resting and stimulated human peripheral blood mononuclear cells
In: Biomedical reports. - Athens : Spandidos Publ, Bd. 2.2014, 2, S. 217-222
2013
Abstrakt
Training intervention improves memory in mild cognitive impairment and healthy controls, but plasma BDNF acts differentially
In: Journal of psychophysiology. - Göttingen : Hogrefe & Huber; Bd. 27.2013, Suppl. 1, S. 49
Aklides - a highly versatile imaging platform for detection of ANCA
In: La presse médicale & Quarterly medical review. - Issy-les-Moulineaux : Elsevier Masson, Bd. 42.2013, 4, S. 686
Begutachteter Zeitschriftenartikel
Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX
In: Journal of leukocyte biology. - Bethesda, Md : FASEB, Bd. 93.2013, 3, S. 353-362
T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice
In: The journal of immunology. - Bethesda, Md : Soc, Bd. 191.2013, 10, S. 4950-4959
Stimulated human peripheral T cells produce high amounts of IL-35 protein in a proliferation-dependent manner
In: Cytokine. - London : Academic Press, Bd. 64.2013, 1, S. 46-50
Humanes Leukozytenantigensystem in der Augenheilkunde
In: Der Ophthalmologe. - Berlin : Springer, Bd. 110.2013, 9, S. 849-861
Crohnʾs disease-specific pancreatic autoantibodies are specifically present in ruminants with paratuberculosis - Implications for the pathogenesis of the human disease
In: Autoimmunity. - London : Informa Healthcare, Bd. 46.2013, 6, S. 388-394
Glycoprotein 2 antibodies in Crohn's disease
In: Advances in clinical chemistry. - New York, NY [u.a.] : Elsevier, Bd. 60.2013, S. 187-208
Glycoprotein 2 antibodies in inflammatory bowel disease - No association with disease phenotype?. Letters to the editor
In: Journal of pediatric gastroenterology and nutrition. - Philadelphia, Pa : Lippincott Williams & Wilkins, Bd. 56.2013, 1, S. 5
Standardization of automated interpretation of immunofluorescence tests. Letter to the editor
In: Clinica chimica acta. - Amsterdam : Elsevier, Bd. 421.2013, S. 168-169
Fully automated analysis of chemically induced [gamma]H2AX foci in human peripheral blood mononuclear cells by indirect immunofluorescence
In: Cytometry. - Hoboken, NJ : Wiley-LissCytometry / A, Bd. 83.2013, 11, S. 1017-1026
Buchbeitrag
DP IV/CD26 effector peptides
In: Handbook of biologically active peptides. - Amsterdam [u.a.] : Elsevier, Acad. Press, S. 664-670, 2013
2012
Originalartikel in begutachteter internationaler Zeitschrift
Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn's disease
In: BMC gastroenterology. - London : BioMed Central, Bd. 12.2012, insges. 9 S.
A new dot immunoassay for simultaneous detection of celiac specific antibodies and IgA-deficiency
In: Clinical chemistry and laboratory medicine. - Berlin : de Gruyter, Bd. 50.2012, 2, S. 337-343
Autoantibody diagnostics in clinical practice
In: Autoimmunity reviews. - Amsterdam [u.a.] : Elsevier, Bd. 11.2012, 3, S. 207-211
Methodologic issues in the measurement of interleukin-16 in clinical blood samples using immunoassays
In: Cytokine. - Philadelphia, Pa : Saunders, Bd. 58.2012, 1, S. 1-5
Automated interpretation of ANCA patterns - a new approach in the serology of ANCA-associated vasculitis
In: Arthritis Research & Therapy. - London : BioMed Central, Bd. 14.2012, 6, insges. 10 S.
Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity
In: Autoimmunity highlights. - Mailand : Springer Milan, Bd. 3.2012, 3, S. 119-125
The Authors' reply. Letter
In: Gut. - London : BMJ Publishing Group, Bd. 61.2012, 1, S. 164-165
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia
In: Journal of neuroinflammation. - London : BioMed Central, Bd. 9.2012, insges. 15 S.
Zinc aspartate suppresses T cell activation in vitro and relapsing experimental autoimmune encephalomyelitis in SJL/J mice
In: BioMetals. - Oxford : Rapid Communications, Bd. 25.2012, 3, S. 529-539
Progressive lipo-lymphedema associated with increased activity of dermal fibroblasts in monoclonal gammopathy of undetermined significance: is there a causal relationship?
In: Lymphology. - Tucson, Ariz : International Society of Lymphology, Bd. 45.2012, 3, S. 124-129
The adapter protein ADAP is required for selected dendritic cell functions
In: Cell communication and signaling. - London : Biomed Central; Bd. 10.2012, Art. 14, insges. 10 S.
Identification of pancreatic glycoprotein 2 as an endogenous immunomodulator of innate and adaptive immune responses
In: The journal of immunology. - Bethesda, Md : American Assoc. of Immunologists, Bd. 189.2012, 6, S. 2774-2783
Pro-inflammatory effector Th cells transmigrate through anti-inflammatory environments into the murine fetus
In: Placenta. - Amsterdam [u.a.] : Elsevier, Bd. 33.2012, 1, S. 39-46
New platform technology for comprehensive serological diagnostics of autoimmune diseases
In: Clinical & developmental immunology. - New York, NY : Hindawi, insges. 8 S., 2012
Originalartikel in begutachteter nationaler Zeitschrift
Altes Immunsystem - neue Erkenntnisse? - Bedeutung mononukleärer Zellen bei der allogenen Hornhauttransplantatabstoßung
In: Der Ophthalmologe. - Heidelberg : Springer-Medizin-Verl, Bd. 109.2012, 9, S. 869-878
Ektopeptidasen - Von der Forschung in die Klinik
In: Aktuelle Dermatologie. - Stuttgart : Thieme, Bd. 38.2012, 3, S. 85-87
2011
Originalartikel in begutachteter internationaler Zeitschrift
Novel aspects of cellular action of dipeptidyl peptidase IV/CD26
In: Biological chemistry. - Berlin [u.a.] : de Gruyter, Bd. 392.2011, 3, S. 153-168
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 6.2011, 9, insges. 7 S.
Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects
In: Biological chemistry. - Berlin [u.a.] : de Gruyter, Bd. 392.2011, 3, S. 169-187
Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions
In: Immunobiology. - Amsterdam : Elsevier, Bd. 216.2011, 12, S. 1295-1301
Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies
In: Autoimmunity reviews. - Amsterdam [u.a.] : Elsevier, Bd. 11.2011, 2, S. 143-148
Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation
In: The journal of immunology. - Bethesda, Md : American Assoc. of Immunologists, Bd. 186.2011, 11, S. 6521-6531
The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I)
In: Cellular immunology. - San Diego, Calif : Elsevier, Bd. 267.2011, 2, S. 88-93
PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J mice
In: Biological chemistry. - Berlin [u.a.] : de Gruyter, Bd. 392.2011, 3, S. 233-237
Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease
In: Clinica chimica acta. - Amsterdam : Elsevier, Bd. 412.2011, 9/10, S. 718-724
Standardized detection of anti-ds DNA antibodies by indirect immunofluorescence - a new age for confirmatory tests in SLE diagnostics. Letter to the editor
In: Clinica chimica acta. - Amsterdam : Elsevier, Bd. 412.2011, 21/22, S. 2011-2012
2010
Originalartikel in begutachteter internationaler Zeitschrift
Profiling of rheumatoid arthritis associated autoantibodies
In: Autoimmunity reviews . - Amsterdam [u.a.] : Elsevier, Bd. 9.2010, 6, S. 431-435
Zinc: a complementary factor in the treatment of chronic hepatitis C? (Review)
In: Molecular medicine reports . - Athens : Spandidos Publ., Bd. 3.2010, 3, S. 371-375
High sensitive detection of double-stranded DNA antibodies by a modified Crithidia luciliae immunofluorescence test may improve diagnosis of systemic lupus erythematosus
In: Clinica chimica acta . - Amsterdam : Elsevier, Bd. 411.2010, 21/22, S. 1837-1838
2009
Buchbeitrag
Ektopeptidaseinhibitoren als Instrumente eines neuen Therapiekonzeptes zur Behandlung der Akne vulgaris
In: Spitzenforschung in der Dermatologie und Allergologie. - Lampertheim : Alpha-Informationsges., insges. 6 S., 2009
Originalartikel in begutachteter internationaler Zeitschrift
Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions
In: Clinical chemistry and laboratory medicine. - Berlin : de Gruyter, Bd. 47.2009, 3, S. 253-261
High sensitive detection of double-stranded DNA autoantibodies by a modified Crithidia luciliae immunofluorescence test
In: Annals of the New York Academy of Sciences . - Boston, Mass. : Blackwell, Bd. 1173.2009, S. 180-185
Plasma concentrations of zinc, copper, interleukin-6 and interferon-[gamma], and plasma dipeptidyl peptidase IV activity in chronic hepatitis C
In: Molecular medicine reports . - Athens : Spandidos Publ., Bd. 2.2009, 1, S. 63-68
Modulation of cytokine production and silica-induced lung fibrosis by inhibitors of aminopeptidase N and of dipeptidyl peptidase-IV-related proteases
In: Life sciences . - New York, NY [u.a.] : Elsevier Science, Bd. 84.2009, 1/2, S. 1-11
Radiation-induced matrix production of lung fibroblasts is regulated by interleukin-8
In: International journal of radiation biology . - Abingdon : Informa Healthcare, Bd. 85.2009, 2, S. 138-143
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 10, S. 6124-6134
Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo
In: Journal of leukocyte biology . - Bethesda, Md. : FASEB, Bd. 86.2009, 1, S. 61-71
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice
In: Clinical chemistry and laboratory medicine. - Berlin : de Gruyter, Bd. 47.2009, 3, S. 268-274
Increased blood plasma concentrations of TGF-[beta]1 and TGF-[beta]2 after treatment with intravenous immunoglobulins in childhood autoimmune diseases
In: Pediatric allergy and immunology . - Oxford : Blackwell Munksgaard, Bd. 20.2009, 3, S. 261-265
High-sensitive detection of autoantibodies against proteinase-3 by a novel third-generation enzyme-linked immunosorbent assay
In: Annals of the New York Academy of Sciences . - Boston, Mass. : Blackwell, Bd. 1173.2009, S. 41-46
Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease
In: Gut . - London : BMJ Publishing Group, Bd. 58.2009, 12, S. 1620-1628
2008
Herausgeberschaft
Zink - Bedeutung in der ärztlichen Praxis
In: Heßdorf-Klebheim: Hartmann, ISBN 978-3-926725-18-9, 2008
Originalartikel in begutachteter internationaler Zeitschrift
Inflammatory bowel diseases: multiple benefits from therapy with dipeptidyl- and alanyl-aminopeptidase inhibitors
In: Frontiers in bioscience . - Searington, NY, Bd. 13.2008, 10, S. 3699-3713
DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis
In: Frontiers in bioscience. - Searington, NY, Bd. 13.2008, 6, S. 2356-2363
Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts
In: The journal of investigative dermatology. - New York, NY : Nature Publishing Group, Bd. 128.2008, 4, S. 855-866
The ectopeptidases dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN) and their related enzymes as possible targets in the treatment of skin diseases
In: Frontiers in bioscience. - Searington, NY, Bd. 13.2008, 6, S. 2364-2375
Non-substrate peptides influencing dipeptidyl peptidase IV/CD26 activity and immune cell function
In: Frontiers in bioscience. - Searington, NY, Bd. 13.2008, 9, S. 3194-3201
2007
Originalartikel in begutachteter internationaler Zeitschrift
Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-[beta]1 and ameliorates acute colitis in mice
In: International journal of molecular medicine . - Athens, Bd. 20.2007, 4, S. 483-492
A new line immunoassay for the multiparametric detection of antiganglioside autoantibodies in patients with autoimmune peripheral neuropathies
In: Autoimmunity; Pt. A: Basic principles and new diagnostic tools . - Boston, Mass. : Blackwell Publ., ISBN 1-573-31663-6, Bd. 1109.2007, S. 256-264
Deletion of the LIME adaptor protein minimally affects T and B cell development and function
In: European journal of immunology . - Weinheim : Wiley VCH, Bd. 37.2007, 11, S. 3259-3269
TGF-[beta]1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 178.2007, 7, S. 4632-4640
Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses
In: New York Academy of Sciences : Annals of the New York Academy of Sciences . - Boston, Mass. : Blackwell, Bd. 1110.2007, S. 402-409
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation
In: The journal of investigative dermatology. - New York, NY : Nature Publishing Group, Bd. 127.2007, 5, S. 1042-1051
2006
Buchbeitrag
Immune peptides related to dipeptidyl aminopeptidase IV/CD26
In: Handbook of biologically active peptides . - Amsterdam [u.a.] : Elsevier / Acad. Press, ISBN 0-12-369442-6, S. 567-572, 2006
Herausgeberschaft
Dipeptidyl aminopeptidases - basic science and clinical applications
In: Advances in experimental medicine and biology; 575
Originalartikel in begutachteter internationaler Zeitschrift
Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13) - a novel approach for the treatment of inflammatory bowel disease
In: International immunopharmacology . - Amsterdam [u.a.] : Elsevier, Bd. 6.2006, 13/14, S. 1925-1934
Normal T-cell development and immune functions in TRIM-deficient mice
In: Molecular and cellular biology . - Washington, DC : American Society for Microbiology, Bd. 26.2006, 9, S. 3639-3648
Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation
In: International immunopharmacology . - Amsterdam [u.a.] : Elsevier, Bd. 6.2006, 13/14, S. 1935-1942
Increased concentrations of transforming growth factor [beta]1 and [beta]2 in the plasma of patients with glioblastoma
In: Journal of neuro-oncology . - Dordrecht : Springer, ISSN 0167-594x, Bd. 79.2006, 1, S. 61-65
Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function
In: Journal of leukocyte biology. - Bethesda, Md : FASEB, Bd. 80.2006, 3, S. 621-629
Originalartikel in begutachteter zeitschriftenartiger Reihe
Dipeptidylpeptidase IV (DPIV) and alanyl-aminopeptidases (AAPs) as a new target complex for treatment of autoimmune and inflammatory diseases - proof of concept in a mouse model of colitis
In: Dipeptidyl aminopeptidases . - New York : Springer Science + Business Media, ISBN 0-387-29058-3, S. 143-153, 2006
Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation
In: Dipeptidyl aminopeptidases . - New York : Springer Science + Business Media, ISBN 0-387-29058-3, S. 177-186, 2006
CD26/DP IV in T cell activation and autoimmunity
In: Dipeptidyl aminopeptidases . - New York : Springer Science + Business Media, ISBN 0-387-29058-3, S. 187-193
Possible role of DP IV inhibitors in acne therapy
In: Dipeptidyl aminopeptidases. - New York : Springer Science + Business Media, S. 163-167, 2006
Expression of dipeptidyl peptidase IV-like enzymes in human peripheral blood mononuclear cells
In: Dipeptidyl aminopeptidases . - New York : Springer Science + Business Media, ISBN 0-387-29058-3, S. 87-91, 2006
2005
Buchbeitrag
Dipeptidyl peptidase IV regulates T cell function in CNS inflammation.
In: Lendeckel, U. (Ed.) ; Hooper, N. (Ed.): Proteases in the brain. New York : Springer, 2005, S. 139 - 150 (Proteases in biology and disease 3)
Originalartikel in begutachteter internationaler Zeitschrift
Liver cirrhosis and "liver" diabetes mellitus are linked by zinc deficiency.
In: Med. Hypotheses 64(2005), Nr. 2, S. 316 - 317
The role of dipeptidyl peptidase IV (DP IV, CD26) in T cell activation and multiple sclerosis.
In: Signal Transduction 5(2005), Nr. 5, S. 258 - 265
Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers.
In: Int. J. Cardiol. 100(2005), Nr. 2, S. 207 - 212
The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.
In: Mol. Cell. Biol. 25(2005), Nr. 17, S. 7557 - 7568
Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.
In: Mol. Cell. Biol. 25(2005), Nr. 18, S. 8052 - 8063
2004
Originalartikel in begutachteter internationaler Zeitschrift
The imbalanced mixed lymphocyte reaction between maternal and fetal lymphocytes as well as between the lymphocytes of adult children and their parents is mediated by activated CD8+ T cells.
In: Am. J. Reprod. Immunol. 52(2004), Nr. 4, S. 284 - 289
Increased blood plasma concentrations of TGF-beta isoforms after treatment with intravenous immunoglobulins (IVIG) in patients with multiple sclerosis.
In: J. Neuroimmunol. 152(2004), Nr. 1-2, S. 191 - 194
Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation.
In: Biochem. Biophys. Res. Commun. 321(2004), Nr. 4, S. 795 - 801
2003
Buchbeitrag
Dipeptidyl peptidase IV inhibitors with the N-terminal MXP sequence : structure-activity- relationships.
In: Hildebrandt, M. (Ed.) ; Klapp, B. (Ed.) ; ... (Ed.): Dipeptidyl aminopeptidases in health and disease. New York [u.a.] : Kluwer Academic/Plenum Publ., 2003, S. 175 - 179 (Advances in experimental medicine and biology ; 524)
Synergistic action of DPIV and APN in the regulation of T cell function.
In: Hildebrandt, M. (Ed.) ; Klapp, B. (Ed.) ; ... (Ed.): Dipeptidyl aminopeptidases in health and disease. New York [u.a.] : Kluwer Academic/Plenum Publ., 2003, S. 123 - 131 (Advances in experimental medicine and biology ; 524)
New results on the conformations of potent DP IV (CD26) inhibitors bearing the N-terminal MWP structural motif.
In: Hildebrandt, M. (Ed.) ; Klapp, B. (Ed.) ; ... (Ed.): Dipeptidyl aminopeptidases in health and disease. New York [u.a.] : Kluwer Academic/Plenum Publ., 2003, S. 65 - 68 (Advances in experimental medicine and biology ; 524)
Immunomodulatory effects of zinc.
In: Bonnekoh, B. (Ed.) ; Gollnick, H. (Ed.): Clinico-experimental advances in dermatological diagnostics and treatment : the proceedings of two scientific workshops, organized in the years 2000 and 2001 by the Department of Dermatology and Venerology, Otto-von-Guericke- University Magdeburg. 1. Aufl. Melsungen : Bibliomed, 2003, S. 157 - 162
Specific inhibition of dipeptidyl peptidase IV (CD26) enzymatic activity - a new approach to psoriasis therapy?.
In: Bonnekoh, B. (Ed.) ; Gollnick, H. (Ed.): Clinico-experimental advances in dermatological diagnostics and treatment : the proceedings of two scientific workshops, organized in the years 2000 and 2001 by the Department of Dermatology and Venerology, Otto-von-Guericke- University Magdeburg. 1. Aufl. Melsungen : Bibliomed, 2003, S. 113 - 119
Originalartikel in begutachteter internationaler Zeitschrift
Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-ß1 production of human immune cells.
In: Z. Naturforsch. C 58c(2003), Nr. 7/8, S. 580 - 589
Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites.
In: Eur. J. Biochem. 270(2003), S. 2147 - 2156
Changes of plasma concentrations of soluble vascular cell adhesion molecule-1 and vascular endothelial growth factor after increased perfusion of lower extremities in humans.
In: Endothelium 10(2003), Nr. 3, S. 159 - 165
2002
Buchbeitrag
CD26/DPIV in diseases of the central nervous system.
In: Langner, J. (Ed.) ; Ansorge, S. (Ed.): Ectopeptidases : CD13/aminopeptidase N and CD26/dipeptidylpeptidase IV in medicine and biology. New York [u.a.] : Kluwer Acad./Plenum Publ., 2002, S. 279 - 287
CD26/DPIV in hematopoietic cells - expression, function, regulation, clinical aspects.
In: Langner, J. (Ed.) ; Ansorge, S. (Ed.): Ectopeptidases : CD13/aminopeptidase N and CD26/dipeptidylpeptidase IV in medicine and biology. New York [u.a.] : Kluwer Acad./Plenum Publ., 2002, S. 197 - 222
Originalartikel in begutachteter internationaler Zeitschrift
Calpains and cytokines in fibrillating human atria.
In: Am. J. Physiol. Heart Circ. Physiol. 283(2002), S. H 264 - H 272
Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL- 8 secretion.
In: J. Biol. Chem. 277(2002), Nr. 21, S. 18440 - 18446
Arthus reaction to lepirudin, a new recombinant hirudin and delayed-type hypersensitivity to several heparins and heparinoids with tolerance to its intravenous administration.
In: Contact Dermatitis 46(2002), Nr. 1, S. 29 - 32
Inhibition of human leukocyte function, alanyl aminopeptidase (APN, CD13) and dipeptidylpeptidase IV (DP IV, CD26) enzymatic activities by aqueous extracts of Cistus incanus L. ssp. incanus.
In: J. Ethnopharmacol. 79(2002), S. 221 - 227
The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity.
In: Biol. Chem. 383(2002), S. 1133 - 1138
2000
Originalartikel in begutachteter internationaler Zeitschrift
Neutrophils synthesize and activate TGFß2.
In: Cytokine 12(2000), Nr. 4, S. 397 - 400
- Immunologie
- Biochemie
- Zellbiologie
- Proteolyse
- Autoimmundiagnostik
- Immunologie
- Biochemie
- Zellbiologie
1981 | Abitur |
1981-1987 | Biomedizin-Studium (2. Medizinisches Institut in Moskau) |
08. 06.1987 | Diplom Thema: "Biochemische und funktionelle Charakteristik der Peritonealmakrophagen von C3HA Mäusen im Verlauf experimenteller Hepatome" |
1987-2000 | wissenschaftlicher Assistent am Institut für Experimentelle Innere Medizin der Otto-von-Guericke-Universität Magdeburg |
1992 | Promotion zum Dr. med. Thema: "Untersuchungen zum Einfluss der Dipeptidylpeptidase IV und der Aminopeptidase N auf die Proliferation von Immunzellen" |
April 2000 | Habilitation, vena legendi für "Immunologie" Thema: "Untersuchungen zur Rolle der enzymatischen Aktivität der Dipeptidylpeptidase IV (DP IV/CD26) bei der T-Zell-aktivierung in vitro und in vivo" |
seit 01. 09. 2000 | Leiter des Bereiches "Autoimmundiagnostik" am Institut für Immunologie der Otto-von-Guericke-Universität Magdeburg |
März 2003 | Hochschuldozent am Institut für Immunologie |