Prof. Leßmann

Prof. Dr. rer. nat. Volkmar Leßmann
Rektorat (R)
Aktuelle Projekte
- ABINEP M2-project 1: Cellular mechanisms of Dopamine and BDNF-Dependent regulation of timing-dependent LTP in CA1 pyramidal neurons
Laufzeit: 01.09.2017 - 31.12.2021 - Synaptic plasticity mechanisms regulating fear memory and fear extinction learning (Mechanismen synaptischer Plastizität bei Furchtlernen und Furchtextinktion)
Laufzeit: 01.01.2016 - 31.12.2019 - CircProt: Synaptic circuit protection in AD and HD: BDNF/TrkB and Arc signaling as rescue factors
Laufzeit: 01.04.2016 - 30.09.2019
Abgeschlossene Projekte
- Die Rolle von BDNF für die Langzeit-Potenzierung in der Amygdala während der Furchtkonditionierung
Laufzeit: 01.01.2012 - 31.12.2015 - Molekulare Regulation der Neuropeptid-Freisetzung aus sekretorischen Granula
Laufzeit: 01.04.2010 - 30.09.2014 - Generierung und Charakterisierung einer knock-in Maus, die BDNF-YFP unter Kontrolle der endogenen regulatorischen Elemente des BDNF-Gens exprimiert.
Laufzeit: 01.01.2009 - 31.12.2013 - In vivo Untersuchungen zur protektiven Wirkung von BDNF (brain-derived neurotrophic fac-tor) auf die Aß-Toxizität bei Morbus Alzheimer
Laufzeit: 01.04.2010 - 31.03.2012 - Die Reizmuster-abhängige Sekretion von Neurotrophinen in synaptischen Netzwerken in vitro
Laufzeit: 01.01.2008 - 31.12.2010 - Regulation der molekularen, strukturellen und physiologischen Differenzierung durch physiologische, elektrische Aktivitätsmuster im neonatalen Säugercortex
Laufzeit: 01.08.2007 - 31.07.2010
2019
Begutachteter Zeitschriftenartikel
Periprosthetic hypoxia as consequence of TRPM7 mediated cobalt influx in osteoblasts
In: Journal of biomedical materials research / B - Hoboken, NJ: Wiley, Bd. 107.2019
2018
Abstrakt
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
In: 11th FENS Forum of Neuroscience: 7-11 July 2018, Berlin, Germany ; abstracts - FENS, 2018, Abstract 3915
Brain-Derived Neurotrophic Factor (BDNF) as a potential biomarker for resting-state network remodeling after ketamine infusion
In: Biological psychiatry: a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry - Amsterdam [u.a.]: Elsevier Science, Bd. 83.2018, Suppl. 9, S140, Seite S402
Begutachteter Zeitschriftenartikel
Daily intermittent normobaric hypoxia over 2 weeks reduces BDNF plasma levels in young adults - a randomized controlled feasibility study
In: Frontiers in physiology - Lausanne: Frontiers Research Foundation, Bd. 9.2018, Art.-Nr. 1337, insges. 7 S.
Generation of functional cardiomyocytes from rat embryonic and induced pluripotent stem cells using feeder-free expansion and differentiation in suspension culture
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 13.2018, 3, Art.-Nr. e0192652, insges. 22 S.
Analyzing synaptic plasticity at the single cell level with STDP
In: Neuroforum: Perspektiven der Hirnforschung : Organ der Neurowissenschaftlichen Gesellschaft - Berlin: De Gruyter, Bd. 24.2018, 3, Seite A143-A150
Dopaminergic innervation and modulation of hippocampal networks
In: Cell & tissue research - Berlin: Springer, Bd. 373.2018, 3, S. 711-727
Dorsal tegmental dopamine neurons gate associative learning of fear
In: Nature neuroscience - New York, NY: Nature America, Bd. 21.2018, 7, S. 952-962
Oxidative stress in drug-naive first episode patients with schizophrenia and major depression - effects of disease acuity and potential confounders
In: European archives of psychiatry and clinical neuroscience - Darmstadt: Steinkopff, Bd. 268.2018, 2, S. 129-143
Presynaptic regulation of tonic inhibition by neuromodulatory transmitters in the basal amygdala
In: Molecular neurobiology - Totowa, NJ: Humana Press, Bd. 55.2018, 11, S. 8509-8521
The relation between long-term synaptic plasticity at glutamatergic synapses in the amygdala and fear learning in adult heterozygous BDNF-knockout mice
In: Cerebral cortex - Oxford: Oxford Univ. Press, Bd. 28.2018, 4, S. 1195-1208
Memory enhancement by ferulic acid ester across species
In: Science advances - Washington, DC [u.a.]: Assoc, Bd. 4.2018, 10, Art.-Nr. eaat6994, insges. 18 S.
Dance training is superior to repetitive physical exercise in inducing brain plasticity in the elderly
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 13.2018, 7, Art.-Nr. e0196636, insges. 15 S.
2017
Abstrakt
Wirkung eines fünfwöchigen Kraftausdauertrainings unter normobarer Hypoxie auf den Serum-BDNF bei jungen vs. älteren Menschen
In: Innovation & Technologie im Sport: 23. dvs-Hochschultag, München, 13.-15. September 2017 : Abstracts - Hamburg: Feldhaus, Edition Czwalina, S. 174 - (Schriften der Deutschen Vereinigung für Sportwissenschaft; 265) ; [Tagung: 23. dvs-Hochschultag, München, 13.-15. September, 2017]
Begutachteter Zeitschriftenartikel
Coexistence of multiple types of synaptic plasticity in individual hippocampal CA1 pyramidal neurons
In: Frontiers in synaptic neuroscience - Lausanne: Frontiers Research Foundation, Bd. 9.2017, Art.-Nr. 7, insges. 15 S.
Evolution of neuroplasticity in response to physical activity in old age - the case for dancing
In: Frontiers in aging neuroscience - Lausanne: Frontiers Research Foundation, Bd. 9.2017, Art.-Nr. 56, insges. 8 S.
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
In: Nature Communications - [London]: Nature Publishing Group UK, Vol. 8.2017, Art. 189, insgesamt 15 S.
Dissertation
Laterale Diffusion Spannungs und/oder Liganden gesteuerter Ionenkanäle als Variable neuronaler Plastizität
In: Magdeburg, 2017, 1 Band (verschiedene Seitenzählungen), Illustrationen, Diagramme, 30 cm ; [Es handelt sich um eine kumulative Schrift, die aus Artikeln und einer vorangestellten Einleitung besteht.; Literaturangaben]
2016
Begutachteter Zeitschriftenartikel
CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons
In: Journal of cell science : Company of Biologists. - Cambridge : Company of Biologists Limited, Bd. 129.2016, 7, S. 1378-1390
Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults
In: NeuroImage : a journal of brain function. - Orlando, Fla : Academic Press, Bd. 131.2016, S. 142-154
Effect of intermittent normobaric hypoxia on aerobic capacity and cognitive function in older people
In: Journal of science and medicine in sport: official journal of Sports Medicine Australia - Amsterdam [u.a.]: Elsevier, Bd. 19.2016, 11, S. 941-945
Amyloid-beta induced changes in vesicular transport of BDNF in hippocampal neurons
In: Neural plasticity - New York, NY: Hindawi, (2016), Article ID 4145708, insges. 15 S.
Dissertation
Regulation der Kalzium-abhängigen Ausschüttung von BDNF aus hippokampalen Neuronen durch CAPS1
In: Magdeburg, 2016, 133 Seiten, Illustrationen, Diagramme, 30 cm ; [Literaturverzeichnis: Seite 124-133]
2015
Abstrakt
Influence of number of spike pairings on induction mechanisms in Spike timing-dependent plasticity
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Vol. 213.2015, Suppl. 699, P101, S. 108
Interaction between amyloid-[beta] peptide and BDNF signalling in hippocampal neurogenesis
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Vol. 213.2015, Suppl. 699, P236, S. 167
CAPS1 critically regulates BDNF release and intragranular pH of secretory granules
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Vol. 213.2015, Suppl. 699, P231, S. 164-165
Coexistence of different forms of timing-dependent LTP at hippocampal CA3-CA1 synapses
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Vol. 213.2015, Suppl. 699, OS2-03, S. 42-43
Fear and fear extinction learning in APP/PS1 mice
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Vol. 213.2015, Suppl. 699, P132, S. 122
Opposing effects of cAMP-effectors PKA and Epac on activity-dependent BDNF secretion in dissociated hippocampal neurons
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Vol. 213.2015, Suppl. 699, P224, S. 162
The second messenger cAMP modulates the secretion of BDNF from dissociated hippocampal neurons
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Vol. 213.2015, Suppl. 699, P228, S. 163-164
Long-term plasticity and fear learning in adult heterozygous BDNF knockout mice
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Vol. 213.2015, Suppl. 699, P138, S. 125
Effect of intermittent normobaric hypoxia on the health status in older people
In: Journal of rehabilitation medicine: official journal of the UEMS European Board of Physical and Rehabilitation Medicine - Uppsala: Foundation for Rehabilitation Information, Bd. 47.2015, Suppl. 54, Abs. PA795, S. 319
Amyloid-beta-induced changes in vesicular transport of BDNF in hippocampal neurons
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Vol. 213.2015, Suppl. 699, P221, S. 161
Increase of BDNF in response to normobaric hypoxia in humans
In: AHA 2015: the book of abstracts Active Healthy Aging Sports Science and Neuroscience International Conference - Magdeburg, S. 110
Systemic hypoxia affects attenuated expression of erythropoietin in old age
In: Acta physiologica / Supplement: official journal of the Federation of European Physiological Societies - Oxford [u.a.]: Wiley-Blackwell, Vol. 213.2015, Suppl. 699, S. 194
Begutachteter Zeitschriftenartikel
Theta burst firing recruits BDNF release and signaling in postsynaptic CA1 neurons in spike-timing-dependent LTP
In: Neuron - [Cambridge, Mass.]: Cell Press, Bd. 86.2015, 4, S. 1041-1054
Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning
In: Neurobiology of learning and memory - Orlando, Fla: Academic Press, Bd. 120.2015, S. 52-60
Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning
In: Neurobiology of learning and memory. - Orlando, Fla : Academic Press, Bd. 120.2015, S. 52-60
Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model
In: Frontiers in behavioral neuroscience - Lausanne: Frontiers Research Foundation, Bd. 9.2015, Art.-Nr.58, insges. 10 S.
Overexpression of BDNF and full-length TrkB receptor ameliorate striatal neural survival in Huntington's disease
In: Neurodegenerative diseases. - Basel : Karger, Bd. 15.2015, 4, S. 207-218
Dissertation
Einfluss der chronischen Reduktion des endogenen Neutrophins BDNF auf kognitive Prozesse im APP/PS1 Alzheimer-Mausmodell
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2015, 2014; 137 S.: graph. Darst.
Habilitation
Anti- und proarrhythmische Wirkung, Verträglichkeit und Sicherheit von Dronedaron (SSR149744C) bei Patienten mit Vorhofflimmern
In: Magdeburg Univ., Med. Fak., Habil.-Schr., 2015, Getr. Zählung, Ill., graph. Darst.
2014
Abstrakt
Single-cell juxtacellular recording and transfection technique
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Bd. 210.2014, Suppl.695, Abs. P262, S. 181-182
Low-repeat STDP paradigms induce dopamine sensitive plasticity in acute hippocampal slices
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Bd. 210.2014, Suppl.695, P252, S. 178
Molecular regulation of Ca2+-dependent neurotrophin secretion in hippocampal neurons by CAPS1
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Bd. 210.2014, Suppl.695, P068, S. 110
Recruitment of BDNF/TrkB signaling in hippocampal mossy fiber LTP depends on stimulation frequency used for LTP induction
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Bd. 210.2014, Suppl.695, P074, S. 112
Influence of the second messenger cAMP on the activity-induced secretion of BDNF in dissociated hippocampal neurons
In: Acta physiologica / Supplement - Oxford [u.a.]: Wiley-Blackwell, Bd. 210.2014, Suppl. 695, OS7-06, S. 70
Begutachteter Zeitschriftenartikel
BDNF - a regulator of learning and memory processes with clinical potential
In: e-Neuroforum: reviews in neuroscience - Heidelberg: Spektrum Akademischer Verlag, Bd. 5.2014, 1, S. 1-11
Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity
In: Neuropharmacology. - Amsterdam [u.a.] : Elsevier Science; Bd. 76, Part C.2014, S. 610-627
BDNF-induced nitric oxide signals in cultured rat hippocampal neurons - time course, mechanism of generation, and effect on neurotrophin secretion
In: Frontiers in cellular neuroscience - Lausanne: Frontiers Research Foundation, Bd. 8.2014, Art.-Nr. 323, insges. 12 S.
Aspekte der Gefäßphysiologie im klinisch-operativen Alltag - basic principles of vascular mechanics
In: Zentralblatt für Chirurgie. - Stuttgart [u.a.] : Thieme, Bd. 139.2014, 5, S. 499-507
Dissertation
Einzelzelltransfektion in organotypischen Schnittkulturen und die Bedeutung von BDNF bei Prozessen der synaptischen Transmission und Plastizität
In: Magdeburg Univ., Fak. für Naturwiss., Diss., 2014, V, 94 Bl., Bl. VII - XI, graph. Darst.
2013
Begutachteter Zeitschriftenartikel
Single-cell juxtacellular transfection and recording technique
In: Pflügers Archiv. - Berlin : Springer, Bd. 465.2013, 11, S. 1637-1649
Dopamine regulates intrinsic excitability thereby gating successful induction of spike timing-dependent plasticity in CA1 of the hippocampus
In: Frontiers in neuroscience. - Lausanne : Frontiers Research Foundation; Vol. 7.2013, Art. 25, insgesamt 11 S.
Embryonic stem cells stably expressing BDNFGFP exhibit a BDNF-release-dependent enhancement of neuronal differentiation
In: Journal of cell science. - Cambridge : Company of Biologists Limited, Bd. 126.2013, 21, S. 5062-5073
Impaired fear extinction learning in adult heterozygous BDNF knock-out mice
In: Neurobiology of learning and memory. - Amsterdam : Elsevier, Bd. 103.2013, S. 34-38
Acute and chronic interference with BDNF/TrkB-signaling impair LTP selectively at mossy fiber synapses in the CA3 region of mouse hippocampus
In: Neuropharmacology. - Amsterdam [u.a.] : Elsevier Science, Bd. 71.2013, S. 247-254
BDNF-dependent consolidation of fear memories in the perirhinal cortex
In: Frontiers in behavioral neuroscience . - Lausanne : Frontiers Research Foundation; Bd. 7.2013, Art.-Nr. 205, insges. 7 S.
2012
Originalartikel in begutachteter internationaler Zeitschrift
Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice
In: Learning & memory. - Plainview, NY : Cold Spring Harbor Laboratory Press, Bd. 19.2012, 12, S. 561-570
Impaired transmission at corticothalamic excitatory inputs and intrathalamic GABAergic synapses in the ventrobasal thalamus of heterozygous BDNF knockout mice
In: Neuroscience. - Oxford : Elsevier, Bd. 222.2012, S. 215-227
Postsynaptic BDNF signalling regulates long-term potentiation at thalamo-amygdala afferents
In: The journal of physiology. - Oxford : Blackwell, Bd. 590.2012, 1, S. 193-208
2011
Originalartikel in begutachteter internationaler Zeitschrift
Dopamine modulates spike timing-dependent plasticity and action potential properties in CA1 pyramidal neurons of acute rat hippocampal slices
In: Frontiers in synaptic neuroscience. - Lausanne : Frontiers Research Foundation, Bd. 3.2011, insges. 16 S.
The expression mechanism of the residual LTP in the CA1 region of BDNF k.o. mice is insensitive to NO synthase inhibition
In: Brain research. - Amsterdam : Elsevier, Bd. 1391.2011, S. 14-23
2010
Originalartikel in begutachteter internationaler Zeitschrift
Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation
In: National Academy of Sciences <Washington, DC> : Proceedings of the National Academy of Sciences of the United States of America . - Washington, DC : NAS, Bd. 107.2010, 24, S. 11116-11121
2009
Originalartikel in begutachteter internationaler Zeitschrift
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
In: Experimental brain research . - Berlin : Springer, Bd. 199.2009, 3/4, S. 203-234
Cellular mechanisms of subplate-driven and cholinergic input-dependent network activity in the neonatal rat somatosensory cortex
In: Cerebral cortex . - New York, NY : Oxford Univ. Press, Bd. 19.2009, 1, S. 89-105
Brain-derived neurotrophic factor signaling in the HVC is required for testosterone-induced song of female canaries
In: The journal of neuroscience . - Washington, DC : Society for Neuroscience, Bd. 29.2009, 49, S. 15511-15519
Activity-dependent dendritic release of BDNF and biological consequences
In: Molecular neurobiology . - Clifton, NJ : Humana Pr., Bd. 39.2009, 1, S. 37-49
Mechanisms of C-reactive protein-induced blood-brain barrier disruption
In: Stroke . - Baltimore, MD : Lippincott Williams &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Wilkins, Bd. 40.2009, 4, S. 1458-1466
Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update
In: Neuroscience research . - Shannon : Elsevier, Bd. 65.2009, 1, S. 11-22
Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death
In: The journal of neuroscience . - Washington, DC : Society for Neuroscience, Bd. 29.2009, 49, S. 15397-15409
A population of serumdeprivation-induced bone marrow stem cells (SD-BMSC) expresses marker typical for embryonic and neural stem cells
In: Experimental cell research . - San Diego, Calif. : Elsevier, Bd. 315.2009, 1, S. 50-66
A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and Rim converge on the N-terminal domain of Munc13-1
In: The journal of neuroscience . - Washington, DC : Society for Neuroscience, Bd. 29.2009, 40, S. 12584-12596
Imaging of evoked dense-core-vesicle exocytosis in hippocampal neurons reveals long latencies and kiss-and-run fusion events
In: Journal of cell science . - Cambridge : Company of Biologists Limited, Bd. 122.2009, 1, S. 75-82
2008
Originalartikel in begutachteter internationaler Zeitschrift
Impaired GABAergic inhibition in the visual cortex of brain-derived neurotrophic factor heterozygous knockout mice
In: The journal of physiology . - Oxford : Blackwell, Bd. 586.2008, 7, S. 1885-1901
Activity-dependent regulation of neuronal apoptosis in neonatal mouse cerebral cortex
In: Cerebral cortex . - New York, NY : Oxford Univ. Press, Bd. 18.2008, 6, S. 1335-1349
Back-propagating action potential - a key contributor in activity-dependent dendritic release of BDNF
In: Communicative &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; integrative biology . - Austin, Tex. : Landes Bioscience, Bd. 1.2008, 2, S. 153-155
Backpropagating action potentials trigger dendritic release of BDNF during spontaneous network activity
In: The journal of neuroscience . - Washington, DC : Society for Neuroscience, Bd. 28.2008, 27, S. 7013-7023
Fluvastatin prevents glutamate-induced blood-brain-barrier disruption in vitro
In: Life sciences . - New York, NY [u.a.] : Elsevier Science, Bd. 82.2008, 25/26, S. 1281-1287
The functional role of the second NPXY motif of the LRP1 [beta]-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors
In: The journal of biological chemistry . - Bethesda, Md. : ASBMB, Bd. 283.2008, 18, S. 12004-12013
2007
Anderes Material
Reduced presynaptic efficiency of excitatory synaptic transmission impairs LTP in the visual cortex of BDNF-heterozygous mice.
In: The European journal of neuroscience, Vol. 24, 2007, S. 3519-31, ISSN Print0953-816X, 10.1111/j.1460-9568.2006.05242.x
Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruption.
In: Journal of neurochemistry, Vol. 102, 2007, S. 501-7, ISSN Print0022-3042, 10.1111/j.1471-4159.2007.04506.x
Presynaptic plasticity in an immature neocortical network requires NMDA receptor activation and BDNF release.
In: Journal of neurophysiology, Vol. 96, 2007, S. 3512-6, ISSN Print0022-3077, 10.1152/jn.00018.2006
Originalartikel in begutachteter internationaler Zeitschrift
Postsynaptic secretion of BDNF and NT-3 from hippocampal neurons depends on calcium-calmodulin kinase II signaling and proceeds via delayed fusion pore opening
In: The journal of neuroscience . - Washington, DC : Society for Neuroscience, Bd. 27.2007, 39, S. 10350-10364
2006
Anderes Material
Differential vesicular targeting and time course of synaptic secretion of the mammalian neurotrophins.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, 2006, S. 7601-14, ISSN 1529-2401, 10.1523/JNEUROSCI.1776-05.2005
N-cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in embryonic stem cell-derived neurons.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, 2006, S. 6968-78, ISSN 1529-2401, 10.1523/JNEUROSCI.1013-06.2006
Fluvastatin stabilizes the blood-brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains.
In: Neuropharmacology, Vol. 51, 2006, S. 907-13, ISSN Print0028-3908, 10.1016/j.neuropharm.2006.06.004
2004
Anderes Material
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
In: Cell, Vol. 118, 2004, S. 127-38, ISSN Print0092-8674, 10.1016/j.cell.2004.06.018
Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor.
In: Journal of cell science, Vol. 117, 2004, S. 5803-14, ISSN Print0021-9533, 10.1242/jcs.01511
2003
Anderes Material
Neurotrophin secretion: current facts and future prospects.
In: Progress in neurobiology, Vol. 69, 2003, S. 341-74, ISSN Print0301-0082
A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors.
In: Trends in pharmacological sciences, Vol. 24, 2003, S. 116-21, ISSN Print0165-6147, 10.1016/S0165-6147(03)00025-7
Developmental maturation of synaptic vesicle cycling as a distinctive feature of central glutamatergic synapses.
In: Neuroscience, Vol. 117, 2003, S. 7-18, ISSN Print0306-4522
2002
Anderes Material
Reduced number of functional glutamatergic synapses in hippocampal neurons overexpressing full-length TrkB receptors.
In: Journal of neuroscience research, Vol. 66, 2002, S. 327-36, ISSN Print0360-4012
2001
Anderes Material
Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses.
In: The EMBO journal, Vol. 20, 2001, S. 5887-97, ISSN Print0261-4189, 10.1093/emboj/20.21.5887
NT-3 regulates BDNF-induced modulation of synaptic transmission in cultured hippocampal neurons.
In: Neuroreport, Vol. 12, 2001, S. 2635-9, ISSN Print0959-4965
Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95.
In: Journal of neurochemistry, Vol. 78, 2001, S. 482-9, ISSN Print0022-3042
2000
Anderes Material
The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain.
In: Oncogene, Vol. 19, 2000, S. 3894-901, ISSN Print0950-9232, 10.1038/sj.onc.1203725
Fast, convenient, and effective method to transiently transfect primary hippocampal neurons.
In: Journal of neuroscience research, Vol. 58, 2000, S. 831-5, ISSN Print0360-4012
Protein expression patterns of identified neurons and of sprouting cells from the leech central nervous system.
In: Journal of neurobiology, Vol. 44, 2000, S. 320-32, ISSN Print0022-3034
1999
Anderes Material
Modulation of unitary glutamatergic synapses by neurotrophin-4/5 or brain-derived neurotrophic factor in hippocampal microcultures: presynaptic enhancement depends on pre-established paired-pulse facilitation.
In: Neuroscience, Vol. 86, 1999, S. 399-413, ISSN Print0306-4522
1998
Anderes Material
BDNF-GFP containing secretory granules are localized in the vicinity of synaptic junctions of cultured cortical neurons.
In: Journal of cell science, Vol. 111 ( Pt 11), 1998, S. 1483-93, ISSN Print0021-9533
Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS.
In: General pharmacology, Vol. 31, 1998, S. 667-74, ISSN Print0306-3623
1997
Anderes Material
Cyclic AMP endogenously enhances synaptic strength of developing glutamatergic synapses in serum-free microcultures of rat hippocampal neurons.
In: Brain research, Vol. 763, 1997, S. 111-22, ISSN Print0006-8993
Differential modulation of AMPA receptor mediated currents by evans blue in postnatal rat hippocampal neurones.
In: British journal of pharmacology, Vol. 121, 1997, S. 237-47, ISSN Print0007-1188, 10.1038/sj.bjp.0701125
1995
Anderes Material
BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones.
In: Neuroreport, Vol. 6, 1995, S. 21-5, ISSN Print0959-4965
Enhancement of postsynaptic serotonin-activated Cl- currents by depolarization-induced Ca2+ entry into leech neurons.
In: Neuroscience, Vol. 67, 1995, S. 525-9, ISSN Print0306-4522
Fast desensitization of glutamate activated AMPA/kainate receptors in rat thalamic neurones.
In: Neuroreport, Vol. 5, 1995, S. 2253-6, ISSN Print0959-4965
Two kinetically distinct 5-hydroxytryptamine-activated Cl- conductances at Retzius P-cell synapses of the medicinal leech.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, 1995, S. 1496-505, ISSN Print0270-6474
1993
Anderes Material
Evans blue reduces macroscopic desensitization of non-NMDA receptor mediated currents and prolongs excitatory postsynaptic currents in cultured rat thalamic neurons.
In: Neuroscience letters, Vol. 146, 1993, S. 13-6, ISSN Print0304-3940
1991
Anderes Material
Development of serotonin-induced ion currents in identified embryonic Retzius cells from the medicinal leech (Hirudo medicinalis).
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 11, 1991, S. 800-9, ISSN Print0270-6474
1990
Anderes Material
Alterations in glycosylation and lectin pattern during phorbol ester-induced differentiation of U937 cells.
In: Cancer research, Vol. 50, 1990, S. 323-7, ISSN Print0008-5472
Insgesamt untersuchen wir auf zellulärem und subzellulärem synaptischen Niveau die Mechanismen der synaptischen Plastizität als Grundlage von Lernen und Gedächtnisbildung.
- Patch-clamp-Ableitungen und extrazelluläre Feldpotentialableitungen in Hippocampus und Amygdala
- Fotostimulation und Patch-clamp-Messung von Channelrhodopsin-exprimierenden Neuronen
- Visualisierung und Analyse der Sekretion GFP-markierter Neuropeptide
- siRNA und microRNA vermittelter knock-down von Proteinen in Hirnschnitten
- Einzelzell-Elektroporation von Neuronen in Hirnschnitten
- Verhaltensphysiologische Untersuchungen zur Furchtkonditionierung
1983-1989 | Studium der Biochemie an der Universität Hannover |
1989 | Diplomprüfung in Biochemie |
1989-1990 | Diplomarbeit am Max-Planck-Institut für Psychiatrie in Martinsried, Abteilung Neurophysiologie (Prof. Dr. H.D. Lux). Titel: "Serotoninantworten embryonaler Nervenzellen von Hirudo medicinalis" |
1990-1993 | Doktorarbeit am MPI für Psychiatrie in Martinsried (Prof. Dr. H.D. Lux), und am Lehrstuhl für Molekulare Neurobiochemie der Ruhr-Universität Bochum (Prof. Dr. R. Heumann). Titel: "Desensitisierung und Modulation transmitteraktivierter Ionenkanäle und ihr Einfluß auf die synaptische Transmission" |
1993-1996 | Postdoktorand am Lehrstuhl für Molekulare Neurobiochemie der Ruhr-Universität Bochum (Prof. Dr. R. Heumann). |
1996-2002 | Wissenschaftlicher Assistent (C1) am Lehrstuhl für Molekulare Neurobiochemie der Ruhr-Universität Bochum (Prof. Dr. R. Heumann). |
Februar 2002 | Habilitation und Venia legendi für das Fach Neurobiochemie. Titel der Habilitationsschrift: "Die Bedeutung neurotropher Faktoren für die Entwicklung und die Funktion chemischer Synapsen des zentralen Nervensystems¿ |
Juli 2002 | Hochschuldozent am Institut für Physiologie & Pathophysiologie der Johannes Gutenberg-Universität Mainz (Prof. Dr. H. Luhmann). |
Mai/Okt. 2003 | Umhabilitation und Venia legendi für das Fach Physiologie. |
Juni 2007 | Amtsantritt als W3-Professor für Physiologie and der Medizinischen Fakultät der Otto-von-Guericke-Universität |
September 2010 | Amtsantritt als Prorektor für Forschung, Technologie und Chancengleichheit |