Prof. Fischer

Prof. Dr. med. Thomas Fischer

Medizinische Fakultät
Zentrum für Innere Medizin (ZIM): Universitätsklinik für Hämatologie und Onkologie (KHAE)
Haus 39, 40, Leipziger Str. 44, 39120, Magdeburg,
Projekte

Aktuelle Projekte

Abgeschlossene Projekte

Publikationen

2018

Begutachteter Zeitschriftenartikel

Edelmann, Bärbel;  Gupta, Nibedita;  Schnöder, Tina;  Oelschlegel, Anja Maria;  Shahzad, Khurrum;  Goldschmidt, Jürgen;  Philipsen, Lars;  Weinert, Sönke;  Ghosh, Aniket;  Saalfeld, Felix C.;  Nimmagadda, Subbaiah Chary;  Müller, Peter;  Braun-Dullaeus, Rüdiger C.;  Mohr, Juliane;  Wolleschak, Denise;  Kliche, Stefanie;  Amthauer, Holger;  Heidel, Florian;  Schraven, Burkhart;  Isermann, Berend;  Müller, Andreas J.;  Fischer, Thomas 

JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation
In: The journal of clinical investigation: JCI : the publication of the American Society for Clinical Investigation - Ann Arbor, Mich: ASCJ, Bd. 128.2018, 10, S. 4359-4371; http://dx.doi.org/10.1172/JCI90312

Maifrede, Silvia;  Nieborowska-Skorska, Margaret;  Sullivan-Reed, Katherine;  Dasgupta, Yashodhara;  Podszywalow-Bartnicka, Paulina;  Le, Bac Viet;  Solecka, Martyna;  Lian, Zhaorui;  Belyaeva, Elizaveta A.;  Nersesyan, Alina;  Machnicki, Marcin M.;  Toma, Monika;  Chatain, Nicolas;  Rydzanicz, Malgorzata;  Zhao, Huaqing;  Jelinek, Jaroslav;  Piwocka, Katarzyna;  Sliwinski, Tomasz;  Stoklosa, Tomasz;  Ploski, Rafal;  Fischer, Thomas;  Sykes, Stephen M.;  Koschmieder, Steffen;  Bullinger, Lars;  Valent, Peter;  Wasik, Mariusz A.;  Huang, Jian;  Skorski, Tomasz 

Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors
In: Blood: journal of the American Society of Hematology - Washington, DC: American Society of Hematology, Bd. 132.2018, 1, S. 67-77; http://dx.doi.org/10.1182/blood-2018-02-834895

Marhäll, Alissa;  Heidel, Florian;  Fischer, Thomas;  Rönnstrand, Lars 

Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation
In: Annals of hematology: organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie - Berlin: Springer, Bd. 97.2018, 5, S. 773-780; http://dx.doi.org/10.1007/s00277-018-3245-5

Nimmagadda, Subbaiah Chary;  Frey, Stephanie;  Edelmann, Baerbel;  Hellmich, Charlotte;  Zaitseva, Lyubov;  König, Gabriele M.;  Kostenis, Eva;  Bowles, Kristian M.;  Fischer, Thomas 

Bruton's tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia
In: Leukemia: normal and malignant hemopoiesis : a peer-reviewed journal - London: Springer Nature, Bd. 32.2018, 3, S. 846-849; http://dx.doi.org/10.1038/leu.2017.324

Schalk, Enrico;  Zeremski, Vanja;  Fischer, Thomas 

Primary ecthyma gangraenosum due to central venous catheter-related bloodstream infection with Pseudomonas aeruginosa
In: Infection - München: Urban & Vogel, Bd. 46.2018, insges. 2 S.; http://dx.doi.org/10.1007/s15010-018-1207-4

Tetschke, Manuel;  Lilienthal, Patrick;  Pottgießer, Torben;  Fischer, Thomas;  Schalk, Enrico;  Sager, Sebastian 

Mathematical modeling of RBC count dynamics after blood loss
In: Processes: open access journal - Basel: MDPI, Vol. 6.2018, 9, Art. 157, insgesamt 29 S.; http://dx.doi.org/10.3390/pr6090157

Nicht begutachteter Zeitschriftenartikel

Fischer, Thomas 

Das internistische Jahr 2017 - die wichtigsten Fortschritte und Entwicklungen
In: Ärzteblatt Sachsen-Anhalt: offizielles Mitteilungsblatt der Ärztekammer Sachsen-Anhalt - Magdeburg: Ärztekammer Sachsen-Anhalt, Bd. 29.2018, 4, S. 17-20; https://www.aerzteblatt-sachsen-anhalt.de/ausgabe/neues-aus-dem-kammerbereich/468-neues-aus-dem-kammerbereich-04-2018/2169-das-internistische-jahr-2017.html

2017

Abstrakt

Agrawal, Mridul;  Jahn, Nikolaus;  Dolnik, Anna;  Cocciardi, Sibylle;  Schmalbrock, Laura K.;  Blätte, Tamara J.;  Gaidzik, Verena Ingeborg;  Lübbert, Michael;  Fiedler, Walter;  Fischer, Thomas;  Brossart, Peter;  Wattad, Mohammed;  Thol, Felicitas;  Heuser, Michael;  Ganser, Arnold;  Schlenk, Richard Friedrich;  Paschka, Peter;  Döhner, Hartmut;  Döhner, Konstanze;  Bullinger, Lars 

Variant allele frequency kinetics of tyrosine kinase gene mutations in core-binding factor acute myeoloid leukemia (CBF-AML) under treatment with and without dasatinib
In: Haematologica: journal of the European Hematology Association - Pavia: Ferrata-Storti Foundation, Bd. 102.2017, Suppl. 2, P535, S. 204-205; http://www.haematologica.org/content/102/s2/1.full.pdf+html

Arra, Aditya;  Lingel, Holger;  Kuropka, Benno;  Fischer, Thomas;  Freund, Christian;  Pierau, Mandy;  Brunner-Weinzierl, Monika 

CTLA-4 mediated effects on STATs regulate differentiation and plasticity of Tc17 cells
In: European journal of immunology - Weinheim: Wiley VCH, Bd. 47.2017, Suppl. 2, P395, S. 277; http://dx.doi.org/10.1002/eji.201770300

Ewers, Katharina M.;  Wolleschak, Denise;  Glade, Julia;  Cammann, Clemens;  Fahldieck, Corinna;  Fischer, Thomas;  Seifert, Ulrike;  Roessner, Albert;  Fröhling, Stefan;  Heidel, Florian;  Schnöder, Tina 

Preclinical evaluation of immuno-/proteasome inhibitors in soft-tissue sarcoma
In: Oncology research and treatment - Basel: Karger, Bd. 40.2017, Suppl. 3, V415, S. 111-112; https://www.karger.com/Article/Abstract/479566

Ionita, Ana;  Wolleschak, Denise;  Geginat, Gernot;  Sauerbrei, Andreas;  Gollnick, Harald;  Malfertheiner, Peter;  Fischer, Thomas;  Heinicke, Thomas 

Three cases of herpes virus reactivation after allogeneic stem cell transplantation
In: Bone marrow transplantation - London: Springer Nature, Bd. 52.2017, Suppl. 1, S. S268; http://www.ebmt2017.org/poster-abstracts

Nagel, Gabriele;  Weber, Daniela;  Fromm, Ella;  Erhardt, Siegfried;  Lübbert, Michael;  Fiedler, Walter;  Kindler, Thomas;  Krauter, Jürgen;  Brossart, Peter;  Kündgen, Andrea;  Salih, Helmut Rainer;  Westermann, Jörg;  Wulf, Gerald;  Hertenstein, Bernd;  Wattad, Mohammed;  Götze, Katharina;  Köhne, Claus-Henning;  Fischer, Thomas;  Girschikofsky, Michael;  Derigs, Hans Günter;  Horst, Heinz August;  Rudolph, Christiane;  Heuser, Michael;  Göhring, Gudrun;  Teleanu, Veronica;  Bullinger, Lars;  Thol, Felicitas;  Gaidzik, Verena Ingeborg;  Paschka, Peter;  Döhner, Konstanze;  Ganser, Arnold;  Döhner, Hartmut;  Schlenk, Richard Friedrich 

Epidemiological, genetic and clinical characterization of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO) (NCT01252485)
In: Oncology research and treatment - Basel: Karger, Bd. 40.2017, Suppl. 3, P198, S. 45-46; https://www.karger.com/Article/Abstract/479566

Nimmagadda, Subbaiah Chary;  Frey, Stephanie;  Edelmann, Bärbel;  Fischer, Thomas 

NFKB pathway promotes tumor progression through Brutons tyrosine kinase in MLL+ acute myeloid leukemia
In: Haematologica: journal of the European Hematology Association - Pavia: Ferrata-Storti Foundation, Bd. 102.2017, Suppl. 2, E865, S. 356-357

Schalk, Enrico;  Färber, Jacqueline;  Schlüter, Dirk;  Teschner, Daniel;  Fischer, Thomas 

A simple prognostic index for prediction of central venous catheter-related bloodstream infections in patients with haematological malignancies (CIPS-H)
In: Oncology research and treatment - Basel: Karger, Bd. 40.2017, Suppl. 3, V765, S. 222; https://www.karger.com/Article/Abstract/479566

Schalk, Enrico;  Zeremski, Vanja;  Fischer, Thomas 

Impact of treatment delay on prognosis in patients with primary CNS lymphoma
In: Oncology research and treatment - Basel: Karger, Bd. 40.2017, Suppl. 3, P282, S. 77; https://www.karger.com/Article/Abstract/479566

Zeremski, Vanja;  Fischer, Thomas;  Schalk, Enrico 

Early death in patients with primary CNS lymphoma
In: Oncology research and treatment - Basel: Karger, Bd. 40.2017, Suppl. 3, P281, S. 76; https://www.karger.com/Article/Abstract/479566

Artikel in Zeitschrift

Bongartz, Hannes;  Heßenkemper, Wiebke;  Müller, Christian;  Fensky, Melissa;  Fritsch, Johannes;  Mandel, Katharina;  Behrmann, Iris;  Haan, Claude;  Fischer, Thomas;  Feller, Stephan M.;  Schaper, Fred 

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells
In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, Bd. 35.2017, S. 37-47; http://dx.doi.org/10.1016/j.cellsig.2017.03.021

Begutachteter Zeitschriftenartikel

Arra, Aditya;  Lingel, Holger;  Kuropka, Benno;  Pick, Jonas;  Schnöder, Tina;  Fischer, Thomas;  Freund, Christian;  Pierau, Mandy;  Brunner-Weinzierl, Monika 

The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs
In: OncoImmunology - Abingdon: Taylor & Franics, Bd. 6.2017, 2, Art.-Nr. e1273300, insges. 5 S.; http://dx.doi.org/10.1080/2162402X.2016.1273300

Einsele, Hermann;  Engelhardt, Monika;  Tapprich, Christoph;  Müller, Jürgen;  Liebisch, Peter;  Langer, Christian;  Kropff, Martin;  Mügge, Lars-Olof;  Jung, Wolfram;  Wolf, Hans-Heinrich;  Metzner, Bernd;  Hart, Christina;  Gramatzki, Martin;  Hertenstein, Bernd;  Pfreundschuh, Michael;  Rösler, Wolf;  Fischer, Thomas;  Maschmeyer, Georg;  Kanz, Lothar;  Heß, Georg;  Jäger, Elke;  Bentz, Martin;  Dürk, Heinz A.;  Salwender, Hans;  Hebart, Holger;  Straka, Christian;  Knop, Stefanie 

Phase II study of bortezomib, cyclophosphamide and dexamethasone as induction therapy in multiple myeloma - DSMM XI trial
In: British journal of haematology: the official journal of the British Society for Haematology and the European Haematology Association - Oxford [u.a.]: Wiley-Blackwell, Bd. 179.2017, 4, S. 586-597; http://dx.doi.org/10.1111/bjh.14920

Einsele, Hermann;  Knop, Stefan Tobias;  Vogel, Martin;  Müller, Jürgen;  Kropff, Martin;  Metzner, Bernd;  Langer, Christian;  Sayer, Herbert;  Jung, Wolfram;  Dürk, Heinz Albert;  Salwender, Hans;  Wandt, Hannes;  Bassermann, Florian;  Gramatzki, Martin;  Rösler, Wolf;  Wolf, Hans-Heinrich;  Brugger, Wolfram;  Engelhardt, Monika;  Fischer, Thomas;  Liebisch, Peter;  Straka, Christian 

Response-adapted consolidation with bortezomib after ASCT improves progression-free survival in newly diagnosed multiple myeloma
In: Leukemia: normal and malignant hemopoiesis : a peer-reviewed journal - London: Springer Nature, Bd. 31.2017, 6, S. 1463-1466; http://dx.doi.org/10.1038/leu.2017.83

Gieseler-Halbach, Steffi;  Meltendorf, Stefan;  Pierau, Mandy;  Weinert, Sönke;  Heidel, Florian;  Fischer, Thomas;  Handschuh, Juliane;  Braun-Dullaeus, Ruediger C.;  Schrappe, Martin;  Lindquist, Jonathan A.;  Mertens, Peter Rene;  Thomas, Ulrich;  Brunner-Weinzierl, Monika 

RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts
In: Cell death and differentiation - Houndmills, Basingstoke: Nature Publishing Group, Bd. 24.2017, 2, S. 371-383; http://dx.doi.org/10.1038/cdd.2016.141

Gupta, Nibedita;  Edelmann, Bärbel;  Schnöder, Tina;  Saalfeld, Felix C.;  Wolleschak, Denise;  Kliche, Stefanie;  Schraven, Burkhart;  Heidel, Florian;  Fischer, Thomas 

JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1
In: Leukemia: normal and malignant hemopoiesis : a peer-reviewed journal - London: Springer Nature, Bd. 31.2017, 5, S. 1223-1226; http://dx.doi.org/10.1038/leu.2017.26

Nishanth, Gopala;  Wolleschak, Denise;  Fahldieck, Corinna;  Fischer, Thomas;  Mullally, Ann;  Perner, Florian;  Schnöder, Tina;  Just, Sissy;  Heidel, Florian;  Schlüter, Dirk 

Gain of function in Jak2V617F positive T-cells. Letter to the editor
In: Leukemia: normal and malignant hemopoiesis : a peer-reviewed journal - London: Springer Nature, Bd. 31.2017, 4, S. 1000-1003; http://dx.doi.org/10.1038/leu.2017.6

Ranjan, Satish;  Goihl, Alexander;  Kohli, Shrey;  Gadi, Ihsan;  Pierau, Mandy;  Shahzad, Khurrum;  Gupta, Dheerendra;  Bock, Fabian Maximilian;  Wang, Hongjie;  Shaikh, Haroon;  Kähne, Thilo;  Reinhold, Dirk;  Bank, Ute;  Zenclussen, Ana Claudia;  Niemz, Jana;  Schnöder, Tina;  Brunner-Weinzierl, Monika;  Fischer, Thomas;  Kalinski, Thomas;  Schraven, Burkhart;  Luft, Thomas;  Hühn, Jochen;  Naumann, Michael;  Heidel, Florian;  Isermann, Berend 

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
In: Nature Communications - [London]: Nature Publishing Group UK, Bd. 8.2017, Art.-Nr. 311, insges. 16 S.; http://dx.doi.org/10.1038/s41467-017-00169-4

Schalk, Enrico;  Biehl, Lena Maria;  Färber, Jacqueline;  Schlüter, Dirk;  Vehreschild, Maria J. G. T.;  Fischer, Thomas 

Determination of a cutoff time point for prophylactic exchange of central venous catheters for prevention of central venous catheterrelated bloodstream infections in patients with hematological malignancies
In: Infection control and hospital epidemiology: the official journal of the Society for Healthcare Epidemiology of America - Cambridge: Cambridge Univ. Press, Bd. 38.2017, 7, S. 888-889; http://dx.doi.org/10.1017/ice.2017.92

Schalk, Enrico;  Zeremski, Vanja;  Fischer, Thomas 

Impact of lymphopenia on prognosis of patients with primary central nervous system lymphoma - Letter to the editor
In: European journal of cancer - Amsterdam [u.a.]: Elsevier, Bd. 75.2017, S. 280-283; http://dx.doi.org/10.1016/j.ejca.2016.11.035

Schlenk, Richard Friedrich;  Frech, Peter;  Weber, Daniela;  Brossart, Peter;  Horst, Heinz August;  Kraemer, Doris;  Held, Gerhard;  Ringhoffer, Mark;  Burchardt, Alexander;  Kobbe, Guido;  Götze, Katharina;  Nachbaur, David;  Fischer, Thomas;  Lübbert, Michael;  Salih, Helmut Rainer;  Salwender, Hans;  Wulf, Gerald;  Koller, Elisabeth;  Wattad, Mohammed;  Fiedler, Walter;  Kremers, Stephan;  Kirchen, Heinz;  Hertenstein, Bernd;  Paschka, Peter;  Gaidzik, Verena Ingeborg;  Teleanu, Veronica;  Heuser, Michael;  Thol, Felicitas;  Döhner, Konstanze;  Krauter, Jürgen;  Ganser, Arnold;  Döhner, Hartmut 

Impact of pretreatment characteristics and salvage strategy on outcome in patients with relapsed acute myeloid leukemia - letter to the editor
In: Leukemia: normal and malignant hemopoiesis : a peer-reviewed journal - London: Springer Nature, Bd. 31.2017, 5, S. 1217-1220; http://dx.doi.org/10.1038/leu.2017.22

Schnöder, Tina;  Eberhardt, Judith;  Koehler, Michael;  Bierhoff, Holger;  Weinert, Sönke;  Pandey, Akhilesh Datt;  Nimmagadda, Subbaiah Chary;  Wolleschak, Denise;  Jöhrens, Korinna;  Fischer, Thomas;  Heidel, Florian 

Cell autonomous expression of CXCL-10 in JAK2V617F-mutated MPN
In: Journal of cancer research and clinical oncology: official organ of the Deutsche Krebsgesellschaft - Berlin: Springer, Bd. 143.2017, 5, S. 807-820; http://dx.doi.org/10.1007/s00432-017-2354-1

Zeremski, Vanja;  Mawrin, Christian;  Fischer, Thomas;  Schalk, Enrico 

Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation - a case report
In: Molecular and clinical oncology: an international journal devoted to oncology - Athens: Spandidos Publ, Bd. 6.2017, 1, S. 79-82; http://dx.doi.org/10.3892/mco.2016.1080

Buchbeitrag

Schalk, Enrico;  Fischer, Thomas 

Tumor-Lyse-Syndrom
In: Gastroenterologie für Intensivmediziner: 68 Abbildungen - Stuttgart: Georg Thieme Verlag, S. 196-199, 2017

2016

Abstrakt

Fischer, Thomas 

Research and science
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Seite 326

Geßner, Daniel;  Deubrecht, Stefanie;  Fischer, Thomas;  Schalk, Enrico 

Effectiveness of tigecycline (TGC) in hematological patients (pts) with persisting or recurring fever - a retrospective, monocentric review of 78 cases
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. P957, Seite 296

Glade, Julia;  Krogel, Christian;  Roessner, Albert;  Fischer, Thomas;  Heidel, Florian;  Wolleschak, Denise 

Characteristics and treatment of sarcoma patients in a single-center analysis
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. P917, Seite 279-280

Müller, Christian;  Schnöder, Tina;  Edelmann-Stephan, Bärbel;  Heßenkemper, Wiebke;  Bongartz, Hannes;  Schaper, Fred;  Fischer, Thomas 

Expression level of JAK2-V617F determines sensitivity to tyrosine kinase inhibitor Ruxolitinib in HEK293 Flp-In cells and can be augmented by treatment with inhibitors of PI3K/Akt pathway in JAK2-V617F - positive murine progenitor cells
In: Oncology research and treatment - Basel: Karger, Bd. 39.2016, Suppl. 3, Abs. P510, Seite 148-149

Müller, Christian;  Schnöder, Tina;  Simeoni, Luca;  Heidel, Florian;  Thurm, Christoph;  Schraven, Burkhart;  Fischer, Thomas 

LPS stimulation induces ROS formation, apoptosis, DNA damage and oxidation of cysteine residues in FLT3-ITD positive cell lines resulting in FLT3-tyrosine kinase inhibitor resistance
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 101.2016, s1, Abs. E877, S. 360

Müller, Christian;  Simeoni, Luca;  Heidel, Florian;  Schraven, Burkhart;  Fischer, Thomas 

Reactive oxygen species (ROS) modulates sensitivity to FLT3-tyrosine kinase inhibitors in murine and human FLT3-ITD positive AML cell lines
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 101.2016, s1, Abs. E885, S. 362-363

Müller, Christian;  Schnöder, Tina M.;  Edelmann-Stephan, Bärbel;  Wolleschak, Denise;  Simeoni, Luca;  Fischer, Thomas 

Regulatory role of intracellular ROS levels and effects of antioxidants (NAC, Tempol) on proliferation, cell cycle and sensitivity to treatment with tyrosine kinase inhibitor Ruxolitinib in JAK2-V617F - positive myeloproliferative neoplasms
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. P509, Seite 148

Niederwieser, Dietger;  Al-Ali, Haifa Kathrin;  Krahl, Rainer;  Kahl, Christoph;  Wolf, Hans-Heinrich;  Kreibich, Ute;  Vucinic, Vladan;  Hähling, Detlev;  Hegenbart, Ute;  Krämer, Alwin;  Hirt, Carsten;  Peter, Norma;  Opitz, Bernhardt;  Florschütz, Axel;  Reifenrath, Kolja Franz Bogislaw;  Schulze, Antje;  Zojer, Niklas;  Scholl, Sebastian;  Jakob, Christian;  Junghanß, Christian;  Pönisch, Wolfram;  Heyn, Simone;  Sayer, Herbert G.;  Hochhaus, Andreas;  Heinicke, Thomas;  Fischer, Thomas;  Dreger, Peter;  Maschmeyer, Georg 

Hematopoietic Stem Cell Transplantation (HSCT) as compared to Consolidation Chemotherapy (CT) increases leukemia free survival in patients between 60 and 75 years with Acute Myelogenous Leukemia (AML) irrespective of the genetic risk - report from the AML 2004 of the East German Study Group (OSHO)
In: Oncology research and treatment - Basel: Karger, Bd. 39.2016, Suppl. 3, V29, S. 2-4; http://dx.doi.org/10.1159/000449050

Schalk, Enrico;  Biehl, Lena Maria;  Färber, Jacqueline;  Huth, Alexandra;  Panse, Jens Peter;  Krämer, Carolin;  Hentrich, Marcus;  Engelhardt, Monika;  Schäfer-Eckart, Kerstin;  Kofla, Grzegorz;  Kiehl, Michael;  Wendtner, Clemens;  Karthaus, Meinolf;  Cornely, Oliver Andreas;  Fischer, Thomas;  Vehreschild, Maria J. G. T. 

Prophylactic exchange of central venous catheters (CVC) for prevention of CVC-related bloodstream infections (CRBSI) in patients with haematological malignancies - indirect evidence from pooled data of the SECRECY registry and the COAT study
In: Oncology research and treatment - Basel: Karger, Bd. 39.2016, Suppl. 3, Abs. V44, Seite 8

Schnöder, Tina M.;  Eberhardt, Judith;  Nimmagadda, Subbaiah Chery;  Weinert, Sönke;  Wolleschak, Denise;  Sammt, Anja;  Fahldieck, Corinna;  Schönborn, Uta;  Fischer, Thomas;  Heidel, Florian H. 

Cell intrinsic induction of IP-10 in MPN
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. V107, Seite 26

Schreder, Martin;  Liebisch, Peter;  Hebart, Holger;  Holler, Ernst;  Engelhardt, Monika;  Metzner, Bernd;  Peest, Dietrich;  Aulitzky, Walter;  Straka, Christian;  Fischer, Thomas;  Sezer, Orhan;  Hentrich, Marcus;  Ostermann, Helmut;  Peschel, Christian;  Heß, Georg;  Hertenstein, Bernd;  Wolf, Hans-Heinrich;  Jung, Wolfram;  Frickhofen, Norbert;  Maschmeyer, Georg;  Langer, Christian;  Meisner, Christoph;  Kanz, Lothar;  Einsele, Hermann;  Knop, Stefan 

Randomized comparison of pegylated IFN-a2b versus IFN-a2b maintenance following tandem autologous transplant in multiple myeloma
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. P546, Seite 163

Artikel in Zeitschrift

Kahl, Christoph;  Krahl, Rainer;  Becker, Cornelia;  Al-Ali, Haifa Kathrin;  Sayer, Herbert, G.;  Schulze, Antje;  Herold, Michael;  Hänel, Mathias;  Scholl, Sebastian;  Hochhaus, Andreas;  Uharek, Lutz;  Maschmeyer, Georg;  Haehling, Detlev;  Junghanß, Christian;  Peter, Norma;  Kämpfe, Dietrich;  Kettner, Erika;  Heinicke, Thomas;  Fischer, Thomas;  Kreibich, Ute;  Wolf, Hans-Heinrich;  Niederwieser, Dietger 

Long-term follow-up of the AML97 study for patients aged 60 years and above with acute myeloid leukaemia - a study of the East German Haematology and Oncology Study Group (OSHO)
In: Journal of cancer research and clinical oncology: official organ of the Deutsche Krebsgesellschaft - Berlin: Springer, Bd. 142.2016, 1, S. 305-315; http://dx.doi.org/10.1007/s00432-015-2045-8

Begutachteter Zeitschriftenartikel

Arreba Tutusaus, Patricia;  Mack, Thomas S.;  Bullinger, Lars;  Schnöder, Tina;  Polanetzki, Anja;  Weinert, Sönke;  Ballaschk, Anne;  Wang, Z.;  Deshpande, Aniruddha Jayant;  Armstrong, Scott A.;  Döhner, Konstanze;  Fischer, Thomas;  Heidel, Florian 

Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo
In: Leukemia: normal and malignant hemopoiesis : a peer-reviewed journal - London: Springer Nature, Bd. 30.2016, 5, S. 1220-1225; http://dx.doi.org/10.1038/leu.2015.292

Ebert, Caroline;  Perner, Florian;  Wolleschak, Denise;  Schnöder, Tina;  Fischer, Thomas;  Heidel, Florian 

Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo
In: Haematologica: journal of the European Hematology Association - Pavia: Ferrata Storti Foundation, Bd. 101.2016, 3, S. e81-e85; http://dx.doi.org/10.3324/haematol.2015.136754

Hermine, Olivier;  Hoster, Eva;  Walewski, Jan;  Bosly, André;  Stilgenbauer, Stephan;  Thieblemont, Catherine;  Szymczyk, Michal;  Bouabdallah, Reda;  Kneba, Michael;  Hallek, Michael;  Salles, Gilles;  Feugier, Pierre;  Ribrag, Vincent;  Birkmann, Josef;  Forstpointner, Roswitha;  Haioun, Corinne;  Hänel, Mathias;  Casasnovas, René Olivier;  Finke, Jürgen;  Peter, Norma;  Bouabdallah, Kamal;  Sebban, Catherine;  Fischer, Thomas;  Dührsen, Ulrich;  Metzner, Bernd;  Maschmeyer, Georg;  Kanz, Lothar;  Schmidt, Christian;  Delarue, Richard;  Brousse, Nicole;  Klapper, Wolfram;  Macintyre, Elizabeth;  Delfau-Larue, Marie-Hélène;  Pott, Christiane;  Hiddemann, Wolfgang;  Unterhalt, Michael;  Dreyling, Martin 

Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger) - a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network
In: The lancet <London> - London [u.a.]: Elsevier, Bd. 388.2016, 10044, S. 565-575; http://dx.doi.org/10.1016/S0140-6736(16)00739-X

Huang, Kezhi;  Yang, Min;  Pan, Zengkai;  Heidel, Florian H.;  Scherr, Michaela;  Eder, Matthias;  Fischer, Thomas;  Büsche, Guntram;  Welte, Karl;  Neuhoff, Nils von;  Ganser, Arnold;  Li, Zhixiong 

Leukemogenic potency of the novel FLT3-N676K mutant
In: Annals of hematology : organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie. - Berlin : Springer, Bd. 95.2016, 5, S. 783-791

Jayavelu, Ashok Kumar;  Müller, Jörg P.;  Bauer, Reinhard;  Böhmer, Sylvia-Annette;  Lässig, Julia;  Cerny-Reiterer, Sabine;  Sperr, Wolfgang R.;  Valent, Peter;  Maurer, Barbara;  Moriggl, Richard;  Schröder, Katrin;  Shah, Ajay M.;  Fischer, Mike;  Scholl, Sebastian;  Barth, Jessica;  Oellerich, Thomas;  Berg, Tobias;  Serve, Hubert;  Frey, Stephanie;  Fischer, Thomas;  Heidel, Florian H.;  Böhmer, Frank-D. 

NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD positive AML cells
In: Leukemia : normal and malignant hemopoiesis ; a peer-reviewed journal. - Basingstoke : Nature Publ. Group, Bd. 30.2016, 2, S. 473-483

Jost, Felix;  Rinke, Kristine;  Fischer, Thomas;  Schalk, Enrico;  Sager, Sebastian 

Optimum experimental design for patient specific mathematical leukopenia models
In: IFAC-PapersOnLine - Frankfurt: Elsevier, Bd. 49.2016, 26, S. 344-349; http://dx.doi.org/10.1016/j.ifacol.2016.12.150 ; [Kongress: Foundations of Systems Biology in Engineering, FOSBE 2016, Magdeburg, Germany, 9-12 October, 2016]

Lipka, Daniel;  Wagner, Marie-Christine;  Dziadosz, Marek;  Fischer, Thomas 

Prolonged cellular midostaurin retention suggests potential alternative dosing strategies for FLT3-ITD-positive leukemias - letter to the editor
In: Leukemia: normal and malignant hemopoiesis : a peer-reviewed journal - London: Springer Nature, Bd. 30.2016, 10, S. 2090-2093; http://dx.doi.org/10.1038/leu.2016.127

Perner, Florian;  Schnöder, Tina M.;  Fischer, Thomas;  Heidel, Florian H. 

Kinomics screening identifies aberrant phosphorylation of CDC25C in FLT3-ITD-positive AML
In: Anticancer research : international journal of cancer research and treatment. - Attiki, Bd. 36.2016, 12, S. 6249-6258

Rinke, Kristine;  Jost, Felix;  Findeisen, Rolf;  Fischer, Thomas;  Bartsch, Rainer;  Schalk, Enrico;  Sager, Sebastian 

Parameter estimation for leukocyte dynamics after chemotherapy
In: IFAC-PapersOnLine - Frankfurt: Elsevier, Bd. 49.2016, 26, S. 44-49; http://dx.doi.org/10.1016/j.ifacol.2016.12.101 ; [Kongress: Foundations of Systems Biology in Engineering, FOSBE 2016, Magdeburg, Germany, 9-12 October, 2016]

Sasse, Stephanie;  Alram, Magdalena;  Müller, Horst;  Smardová, Lenka;  Metzner, Bernd;  Döhner, Hartmut;  Fischer, Thomas;  Niederwieser, Dietger W.;  Schmitz, Norbert;  Schäfer-Eckart, Kerstin;  Raemaekers, John M. M.;  Schmalz, Oliver;  Tresckow, Bastian von;  Engert, Andreas;  Borchmann, Peter 

Prognostic relevance of DHAP dose-density in relapsed Hodgkin lymphoma - an analysis of the German Hodgkin-Study Group
In: Leukemia and lymphoma. - London [u.a.] : Taylor &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Francis Group, Bd. 57.2016, 5, S. 1067-1073

Schalk, Enrico;  Fischer, Thomas 

Biased low incidence of central venous catheter-related bloodstream infections in controlled clinical trials? - letter to the editor
In: Infection control and hospital epidemiology: the official journal of the Society for Healthcare Epidemiology of America - Cambridge: Cambridge Univ. Press, Bd. 37.2016, 5, S. 617-619; http://dx.doi.org/10.1017/ice.2016.36

Schalk, Enrico;  Fischer, Thomas 

Hemophagocytic lymphohistiocytosis as an unusual cause of prolonged bicytopenia after chemotherapy
In: Clinical Case Reports - Chichester: Wiley, Bd. 4.2016, 10, S. 1017-1018; http://dx.doi.org/10.1002/ccr3.656

Zeremski, Vanja;  Koehler, Michael;  Fischer, Thomas;  Schalk, Enrico 

Characteristics and outcome of patients with primary CNS lymphoma in a real-life setting compared to a clinical trial
In: Annals of hematology : organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie. - Berlin : Springer, Bd. 95.2016, 5, S. 793-799

Buchbeitrag

Mantzke, Andreas;  Fischer, Thomas;  Leone, Marco 

Verminderung der magnetischen Nahfeldeinkopplung auf Leiterplattenebene durch reziproke Systemanalysen
In: EMV 2016 : Internationale Fachmesse und Kongress für Elektromagnetische Verträglichkeit : Düsseldorf, 23. - 25.02.2016. - Aachen : Apprimus Verlag, S. 669-676 ; [Kongress: EMV 2016, Internationale Fachmesse und Kongress für Elektromagnetische Verträglichkeit, Düsseldorf, 23. - 25.02.2016]

Nicht begutachteter Zeitschriftenartikel

Braun-Dullaeus, Rüdiger C. 

Das internistische Jahr 2015 - die wichtigsten Fortschritte und Entwicklungen
In: Ärzteblatt Sachsen-Anhalt: offizielles Mitteilungsblatt der Ärztekammer Sachsen-Anhalt - Magdeburg: Ärztekammer Sachsen-Anhalt, Bd. 27.2016, 5, S. 19-22; https://www.aerzteblatt-sachsen-anhalt.de/ausgabe/neues-aus-dem-kammerbereich/321-neues-aus-dem-kammerbereich-05-2016/1394-das-internistische-jahr-2015-die-wichtigsten-fortschritte-und-entwicklungen.html

2015

Abstrakt

Arreba-Tutusaus, Patricia;  Schnoeder, Tina;  Fischer, Thomas;  Heidel, Florian H. 

Requirement for phospholipase C gamma 1 (PLCG1) in development and maintenance of hematopoietic stem- and progenitor cells
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 100.2015, Suppl. 1, Abs. E1133, S. 452

Einsele, Hermann;  Vogel, Martin;  Müller, Jürgen;  Knop, Stefan;  Kropff, Martin;  Langer, Christian;  Sayer, Herbert;  Jung, Wolfram;  Wandt, Hannes;  Bassermann, Florian;  Gramatzki, Martin;  Rösler, Wolf;  Brugger, Wolfram;  Engelhardt, Monika Martha;  Fischer, Thomas;  Giagounidis, Aristoteles;  Heidemann, Else;  Kröger, Nicolaus;  Sezer, Orhan;  Bentz, Martin;  Pfreundschuh, Michael;  Salwender, Hans;  Ludwig, Wolf-Dieter;  Röllig, Christoph;  Staib, Peter;  Runde, Volker;  Scheid, Christof;  Ostermann, Helmut;  Heß, Georg;  Hebart, Holger;  Repp, Roland;  Hart, Christina;  Frickhofen, Norbert;  Straka, Christian;  Pflüger, Karl-Heinz 

Results from two phase 3 studies of post-transplant bortezomib (BTZ) consolidation vs observation (OBS) in patients with newly diagnosed multiple myeloma (NDMM)
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 100.2015, Suppl. 1, Abs. S426, S. 151

Huang, Kezhi;  Yang, Min;  Pan, Zengkai;  Heidel, Florian H.;  Scherr, Michaela;  Eder, Matthias;  Fischer, Thomas;  Büsche, Guntram;  Neuhoff, Nils von;  Ganser, Arnold;  Li, Zhixiong 

The novel FLT3-N676K mutant induces acute leukemia independently of the Inv(16) chimeric gene CBFB-MYH11
In: Blood : journal of the American Society of Hematology. - Stanford, Calif : HighWire Press, Bd. 126.2015, 23, S. 1383

Koehler, Michael;  Hoppe, Susanne;  Peplinski, D.;  Richter, Diana;  Frommer, Jörg;  Flechtner, Hans-Henning;  Fischer, Thomas 

Psycho-oncologic interventions for parents of cancer patients - systematic review
In: Oncology research and treatment. - Basel : Karger; Bd. 38.2015, Suppl. 5, V565, S. 172

Koehler, Michael;  Fischer, Thomas;  Kropf, Siegfried;  Frommer, Jörg 

The somatic burden score - a quantitative tool to evaluate the somatic burden due to chemotherapy-induced adverse events
In: Oncology research and treatment. - Basel : Karger; Bd. 38.2015, Suppl. 5, V630, S. 192

Mohr, Juliane;  Frey, Stephanie;  Bullinger, Lars;  Schnöder, Tina;  Weinert, Soenke;  Huber, Tobias;  Kaehne, Thilo;  Armstrong, Scott A.;  Fischer, Thomas;  Heidel, Florian 

Distinct and non-overlapping functions of LLGL1 and scribble in hematopoietic stem cells
In: Experimental hematology: journal for hematology, stem cell biology and transplantation : official publication of the ISEH - International Society for Experimental Hematology - Kidlington [u.a]: Elsevier, Bd. 43.2015, 9 Suppl., Abs. 3065, S. S67; http://www.exphem.org/issue/S0301-472X%2814%29X0015-9?page=2

Schalk, Enrico;  Färber, Jacqueline;  Fischer, Thomas 

Delayed entry of blood cultures into blood culture incubators has no negative effect of on overall culture positivity
In: Oncology research and treatment. - Basel : Karger; Bd. 38.2015, Suppl. 5, V628, S. 191-192

Straka, Christian;  Vogel, Martin;  Müller, Jürgen;  Kropff, Martin;  Metzner, Bernd;  Langer, Christian;  Sayer, Herbert;  Jung, Wolfram;  Dürk, Heinz Albert;  Wandt, Hannes;  Bassermann, Florian;  Gramatzki, Martin;  Rösler, Wolf;  Knop, Stefan;  Wolf, Hans-Heinrich;  Brugger, Wolfram;  Engelhardt, Monika;  Fischer, Thomas;  Einsele, Hermann 

Results from two phase III studies of bortezomib (BTZ) consolidation vs observation (OBS) post-transplant in patients (pts) with newly diagnosed multiple myeloma (NDMM)
In: Journal of clinical oncology / Englische Ausgabe - Alexandria, Va: American Society of Clinical Oncology, Bd. 33.2015, 15 Suppl., Abs. 8511, insges. 1 S.; http://meeting.ascopubs.org/content/vol33/15_suppl

Zeremski, Vanja;  Koehler, Michael;  Fischer, Thomas;  Schalk, Enrico 

A pro-active follow-up with higher completeness can significantly influence survival data
In: Oncology research and treatment. - Basel : Karger; Bd. 38.2015, Suppl. 5, P508, S. 155

Zeremski, Vanja;  Fischer, Thomas;  Schalk, Enrico 

Clinical outcome of primary CNS lymphoma comparing the setting of real-life with a clinical trial - a single centre experience of 95 patients
In: Oncology research and treatment. - Basel : Karger; Bd. 38.2015, Suppl. 5, V707, S. 211-212

Begutachteter Zeitschriftenartikel

Heidel, Florian;  Arreba-Tutusaus, Patricia;  Armstrong, Scott A.;  Fischer, Thomas 

Evolutionarily conserved signaling pathways - Acting in the shadows of acute myelogenous leukemia's genetic diversity
In: Clinical cancer research - Philadelphia, Pa. [u.a.]: AACR, Bd. 21.2014, 2, S. 240-248, 2015; http://dx.doi.org/10.1158/1078-0432.CCR-14-1436

Heinicke, Thomas;  Hütten, Heiko;  Kalinski, Thomas;  Franke, Ingolf;  Bonnekoh, Bernd;  Fischer, Thomas 

Sustained remission of blastic plasmacytoid dendritic cell neoplasm after unrelated allogeneic stem cell transplantation - a single center experience
In: Annals of hematology: organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie - Berlin: Springer, Bd. 94.2015, 2, S. 283-287; http://dx.doi.org/10.1007/s00277-014-2193-y

Koehler, Michael;  Fischer, Thomas 

How health-related quality-of-life outcomes in patients with acute promyelocytic leukemia can help physicians in decision making. Correspondence
In: Journal of clinical oncology: JCO : official journal of the American Society of Clinical Oncology - Alexandria, Va: American Society of Clinical Oncology, Bd. 33.2015, 9, S. 1090-1091; http://dx.doi.org/10.1200/JCO.2014.60.2078

Korfel, Agnieszka;  Thiel, Eckhard;  Martus, Peter;  Möhle, Robert;  Griesinger, Frank;  Rauch, Michael;  Röth, Alexander;  Hertenstein, Bernd;  Fischer, Thomas;  Hundsberger, Thomas;  Mergenthaler, Hans G.;  Junghanß, Christian;  Birnbaum, Tobias;  Fischer, Lars;  Jahnke, Kristoph;  Herrlinger, Ulrich;  Roth, Patrick;  Bamberg, Michael;  Pietsch, Torsten;  Weller, Michael 

Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma
In: Neurology: official journal of the American Academy of Neurology - Philadelphia, Pa: Wolters Kluwer, Bd. 84.2015, 12, S. 1242-1248; http://dx.doi.org/10.1212/WNL.0000000000001395

Neumann, Jens;  Riek-Burchardt, Monika;  Herz, Josephine;  Döppner, Thorsten Roland;  König, Rebecca;  Hütten, Heiko;  Etemire, Eloho;  Männ, Linda;  Klingberg, Anika;  Fischer, Thomas;  Görtler, Michael;  Heinze, Hans-Jochen;  Reichardt, Peter;  Schraven, Burkhart;  Hermann, Dirk Matthias;  Reymann, Klaus G.;  Gunzer, Matthias 

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
In: Acta neuropathologica - Berlin: Springer, Bd. 129.2015, 2, S. 259-277; http://dx.doi.org/10.1007/s00401-014-1355-2

Perner, Florian;  Schnöder, Tina M.;  Ranjan, Satish;  Wolleschak, Denise;  Ebert, Carolin;  Pils, Marina C.;  Frey, Stephanie;  Polanetzki, Anja;  Fahldieck, Corinna;  Schönborn, Uta;  Schraven, Burkhart;  Isermann, Berend;  Fischer, Thomas;  Heidel, Florian H. 

Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function
In: Leukemia : normal and malignant hemopoiesis ; a peer-reviewed journal. - Basingstoke : Nature Publ. Group, Bd. 30.2016, 4, S. 991-995

Schalk, Enrico;  Färber, Jacqueline;  Fischer, Thomas;  Heidel, Florian 

Central venous catheter-related bloodstream infections in obese hematologic patients. Letter to the editor
In: Infection control and hospital epidemiology: the official journal of the Society for Healthcare Epidemiology of America - Cambridge: Cambridge Univ. Press, Bd. 36.2015, 8, S. 995-996; http://dx.doi.org/10.1017/ice.2015.107

Schalk, Enrico;  Hanus, Lynn;  Färber, Jacqueline;  Fischer, Thomas;  Heidel, Florian 

Prediction of central venous catheterrelated bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified Infection Probability Score (mIPS)
In: Annals of hematology: organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie - Berlin: Springer, Bd. 94.2015, 9, S. 1451-1456; http://dx.doi.org/10.1007/s00277-015-2387-y

Schalk, Enrico;  Garlipp, Benjamin;  Bruns, Christiane J.;  Fischer, Thomas 

Weichteiltumoren - allgemein-klinische Aspekte ; chirurgische und medikamentöse Therapie
In: Der Onkologe : Organ der Deutschen Krebsgesellschaft e.V. - Berlin : Springer, Bd. 21.2015, 12, S. 1147-1161

Schnöder, Tina;  Arreba-Tutusaus, Patricia;  Griehl, Inga;  Bullinger, Lars;  Buschbeck, Marcus;  Lane, Steven W.;  Döhner, Konstanze;  Plass, Christoph;  Lipka, Daniel;  Heidel, Florian;  Fischer, Thomas 

Epo-induced erythroid maturation is dependent on Plc[gamma]1 signaling
In: Cell death and differentiation - Houndmills, Basingstoke: Nature Publishing Group, Bd. 22.2015, 6, S. 974-985; http://dx.doi.org/10.1038/cdd.2014.186

Buchbeitrag

Mantzke, Andreas;  Leone, Marco;  Fischer, Thomas 

Efficient analysis and reduction of magnetic near-field-coupling in mixed-signal PCBs via the reciprocity principle
In: Proceedings of IEEE International Symposium on Electromagnetic Compatibility and EMC Europe. - Piscataway, NJ : IEEE, S. 91-95, 2015

Nicht begutachteter Zeitschriftenartikel

Fischer, Thomas;  Schalk, Enrico 

Eine Ärztin mit großem Einsatz und bei Patienten und MItarbeitern gleichermaßen beliebt - Im Gedenken an Prof. Dr. med. Astrid Franke
In: UMMD aktuell: Informationen für Patienten, Mitarbeiter und Studierende des Universitätsklinikums Magdeburg A.ö.R. und der Medizinischen Fakultät der Otto-von-Guericke-Universität Magdeburg - Magdeburg: Klinikumsvorstand, 1, S. 15, 2015

2014

Abstrakt

Arreba-Tutusaus, Patricia;  Mack, Thomas;  Bullinger, Lars;  Polanetzki, Anja;  Schnöder, Tina;  Döhner, Konstanze;  Fischer, Thomas;  Heidel, Florian 

Distinct biological and transcriptional features of FLT3-ITD variants in vitro and in vivo
In: Oncology research and treatment - Basel: Karger, Bd. 37.2014, Suppl. 5, V641, S. 206; http://www.karger.com/Journal/Issue/262103

Gehring, Sonja;  Färber, Jacqueline;  Fischer, Thomas;  Schalk, Enrico 

Epidemiological analysis of multidrug-resistant Gramnegative bacteria (MRGN) among haemato-oncological patients
In: Oncology research and treatment - Basel: Karger, Bd. 37.2014, Suppl. 5, P874, S. 292; http://www.karger.com/Journal/Issue/262103

Korfel, Agnieszka;  Thiel, Eckhard;  Martus, Peter;  Möhle, Robert;  Griesinger, Frank;  Rauch, Michael;  Röth, Alexander;  Hertenstein, Bernd;  Fischer, Thomas;  Hundsberger, Thomas;  Mergenthaler, Hans-Günther;  Junghanß, Christian;  Birnbaum, Tobias;  Fischer, Lars;  Jahnke, Kristoph;  Herrlinger, Ulrich;  Roth, Patrick;  Bamberg, Michael;  Pietsch, Torsten;  Weller, Michael 

G-PCNSL-SG-1 randomised phase III trial of high-dose methotrexate with or without whole-brain radiotherapy for primary central nervous system lymphoma (PCNSL) - long-term follow-up
In: Oncology research and treatment - Basel: Karger, Bd. 37.2014, Suppl. 5, V122, S. 33; http://www.karger.com/Journal/Issue/262103

Mashamba, Nomusa;  Wolleschak, Denise;  Thangapandi, Veera R.;  Frey, Stephanie;  Schnöder, Tina;  Fischer, Thomas;  Heidel, Florian 

Impact of cold shock protein Ybx1 on hematopoietic stem cell development and function
In: Haematologica: journal of the European Hematology Association - Pavia: Ferrata-Storti Foundation, Bd. 99.2014, Suppl.1, S. 175-176; http://www.haematologica.org/content/99/supplement_1

Müller, Christian;  Schröder, Nicolas Wolfgang Jörg;  Becker, Elke;  Tanev, Ivan;  Smid, Jan;  Heidel, Florian;  Schalk, Enrico;  Wolleschak, Denise;  Hanus, Lynn;  Fischer, Thomas 

Rapid induction of cytological remission by bendamustine in a rare case of T-PLL with leukostasis symptoms
In: Oncology research and treatment - Basel: Karger, Bd. 37.2014, Suppl. 5, P787, S. 258; http://www.karger.com/Journal/Issue/262103

Perner, Florian;  Mack, Thomas S.;  Schnöder, Tina;  Heidel, Florian;  Fischer, Thomas 

Overexpression of the Cell Division Cycle 25C phosphatase in a two-hit-model of acute myeloid leukemia (AML) suppresses apoptosis upon cytotoxic treatment
In: Oncology research and treatment - Basel: Karger, Bd. 37.2014, Suppl. 5, P417, S. 125; http://www.karger.com/Journal/Issue/262103

Rinke, Kristine;  Bartsch, Rainer;  Fischer, Thomas;  Schalk, Enrico;  Sager, Sebastian 

Mathematical modelling of neutropenia of AML patients treated with chemotherapy
In: Oncology research and treatment - Basel: Karger, Bd. 37.2014, Suppl. 5, P501, S. 159; http://www.karger.com/Journal/Issue/262103

Schalk, Enrico;  Hanus, Lynn;  Färber, Jacqueline;  Fischer, Thomas;  Heidel, Florian 

Prediction of central venous catheter- (CVC-) related bloodstream infections (CRBSIs) in cancer patients (pts) using the Infection Probability Score (IPS): first results from the SECRECY registry
In: Oncology research and treatment - Basel: Karger, Bd. 37.2014, Suppl. 5, V301, S. 94; http://www.karger.com/Journal/Issue/262103

Schnöder, Tina;  Pandey, Akhilesh Datt;  Nimmagadda, Subbaiah Chery;  Wang, Xu;  Maubach, Gunter;  Wolleschak, Denise;  Naumann, Michael;  Schlüter, Dirk;  Lane, Steven W.;  Mullally, Ann;  Heidel, Florian;  Fischer, Thomas 

JAK2V617F mutation is sufficient for autocrine induction of IP-10 in hematopoietic cells
In: Oncology research and treatment - Basel: Karger, Bd. 37.2014, Suppl. 5, V618, S. 199; http://www.karger.com/Journal/Issue/262103

Begutachteter Zeitschriftenartikel

Benderska, Natalya;  Ivanovska, Jelena;  Rau, Tilman Tassilo Rupert;  Schulze-Lührmann, Jan;  Mohan, Suma;  Chakilam, Saritha;  Gandesiri, Muktheshwar;  Ziesché, Elisabeth;  Fischer, Thomas;  Söder, Stephan;  Agaimy, Abbas;  Distel, Luitpold;  Sticht, Heinrich;  Mahadevan, Vijayalakshmi;  Schneider-Stock, Regine 

DAPK-HSF1 interaction as a positive-feedback mechanism stimulating TNF-induced apoptosis in colorectal cancer cells
In: Journal of cell science: Company of Biologists - Cambridge: Company of Biologists Limited, Bd. 127.2014, 24, S. 5273-5287; http://dx.doi.org/10.1242/jcs.157024

Koehler, Michael;  Fischer, Thomas;  Kropf, Siegfried;  Frommer, Jörg 

Quantitative tool to evaluate the somatic burden due to chemotherapy-induced adverse events - the somatic burden score
In: Supportive care in cancer. - Berlin : Springer, Bd. 22.2014, 11, S. 3089-3099

Krüger, William H.;  Hirt, Carsten;  Basara, Nadezda;  Sayer, Herbert G.;  Behre, Gerhard;  Fischer, Thomas;  Grobe, Norbert;  Maschmeyer, Georg;  Niederwieser, Dietger;  Dölken, Gottfried 

Allogeneic stem cell transplantation for mantle cell lymphoma - final report from the prospective trials of the East German Study Group Haematology/Oncology (OSHO)
In: Annals of hematology. - Berlin : Springer, Bd. 93.2014, 9, S. 1587-1597

Schalk, Enrico;  Färber, Jacqueline;  Fischer, Thomas 

Multidrug-resistant gram-negative bacteria in hematology and oncology
In: Infection control and hospital epidemiology: the official journal of the Society for Healthcare Epidemiology of America - Cambridge: Cambridge Univ. Press, Bd. 35.2014, 9, S. 1203-1204; http://dx.doi.org/10.1086/677646

Schalk, Enrico;  Geginat, Gernot;  Schulz, Christian;  Schlüter, Dirk;  Fischer, Thomas 

The incidence of norovirus infections in cancer patients shows less seasonal variability compared to patients with other diseases. Letter to the editor
In: Annals of hematology. - Berlin : Springer, Bd. 93.2014, 5, S. 889-890

Wolleschak, Denise;  Mack, Thomas S.;  Perner, Florian;  Frey, Stephanie;  Schnöder, Tina;  Wagner, Marie-Christine;  Höding, Christine;  Pils, Marina C.;  Parkner, Andreas;  Kliche, Stefanie;  Schraven, Burkhart;  Hebel, Katrin;  Brunner-Weinzierl, Monika;  Ranjan, Satish;  Isermann, Berend;  Lipka, Daniel;  Fischer, Thomas;  Heidel, Florian 

Clinically relevant doses of FLT3-kinase inhibitors Quizartinib and Midostaurin do not impair T-cell reactivity and function
In: Haematologica: journal of the European Hematology Association - Pavia: Ferrata Storti Foundation, Bd. 99.2014, 6, S. e90-e93; http://dx.doi.org/10.3324/haematol.2014.104331

2013

Abstrakt

Hanus, Lynn;  Schalk, Enrico;  Schulz, Christian;  Bartsch, Peter;  Tanev, Ivan;  Malfertheiner, Peter;  Mertens, Peter;  Braun-Dullaeus, Rüdiger;  Fischer, Thomas 

A case of acute myeloid leucaemia after EHEC infection
In: Onkologie. - Basel : Karger; Bd. 36.2013, Suppl. 7, P565, S. 166

Heinicke, Thomas;  Hütten, Heiko;  Fischer, Thomas 

Allogeneic stem cell transplantation for blastic plasmacytoid dendritic cell neoplasm
In: Bone marrow transplantation. - London : Nature Publishing Group; Bd. 48.2013, Suppl.2s, R1531, S. S541

Koehler, Michael;  Fischer, Thomas 

Health-related quality of life and distress in patients with systemic malignancies stratified by age: AYA patients have the worst mental health
In: Onkologie. - Basel : Karger; Bd. 36.2013, Suppl. 7, V399, S. 108-109

Koehler, Michael;  Hoppe, Susanne;  Bartsch, Rainer;  Frommer, Jörg;  Flechtner, Hans-Henning;  Jentsch-Ullrich, Kathleen;  Heidel, Florian;  Fischer, Thomas 

The Magdeburg model of care for adolescents and young adults with cancer (MC AYA): A pilot approach
In: Onkologie. - Basel : Karger; Bd. 36.2013, Suppl. 7, P552, S. 162

Krogel, Christian;  Schalk, Enrico;  Wolleschak, Denise;  Fischer, Thomas;  Heidel, Florian 

Successful treatment of recurrent Desmoid fibromatosis in an adult using low dose chemotherapy with methotrexate and vinblastine
In: Onkologie. - Basel : Karger; Bd. 36.2013, Suppl. 7, P819, S. 249

Schalk, Enrico;  Geginat, Gernot;  Schulz, Christian;  Schlüter, Dirk;  Fischer, Thomas 

Epidemiological data on norovirus infections in cancer patients, 2009-2012
In: Onkologie. - Basel : Karger; Bd. 36.2013, Suppl. 7, P271, S. 82

Begutachteter Zeitschriftenartikel

Caldarelli, Antonio;  Müller, Jörg P.;  Paskowski-Rogacz, Maciej;  Herrmann, Katja;  Bauer, Reinhard;  Koch, S.;  Heninger, Anne-Kristin;  Krastev, Dragomir;  Ding, Li;  Kasper, Stefan;  Fischer, Thomas;  Brodhun, Michael;  Böhmer, Frank-D.;  Buchholz, Frank 

A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 27.2013, insges. 10 S.

DeAngelo, Daniel J.;  Spencer, Andrew;  Bhalla, Kapil N.;  Prince, H. Miles;  Fischer, Thomas;  Kindler, Thomas;  Giles, Francis J.;  Scott, Jeffrey W.;  Parker, Katie;  Liu, Angela;  Woo, Margaret;  Atadja, Peter;  Mishra, K. K.;  Ottmann, Oliver G. 

Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 27.2013, 8, S. 1628-1636

Heidel, Florian H.;  Bullinger, Lars;  Arreba-Tutusaus, Patricia;  Wang, Zhu;  Gaebel, Julia;  Hirt, Carsten;  Niederwieser, Dietger;  Lane, Steven W.;  Döhner, Konstanze;  Vasioukhin, Valera;  Fischer, Thomas;  Armstrong, Scott A. 

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML
In: The journal of experimental medicine. - New York, NY : Rockefeller Univ. PressThe journal of experimental medicine <New York, NY>, Bd. 210.2013, 1, S. 15-22

Ivanovska, Jelena;  Tregubova, Alexandra;  Mahadevan, Vijayalakshmi;  Chakilam, Saritha;  Gandesiri, Muktheshwar;  Benderska, Natalya;  Ettle, Benjamin;  Hartmann, Arndt;  Söder, Stephan;  Ziesché, Elisabeth;  Fischer, Thomas;  Lautscham, Lena;  Fabry, Ben;  Segerer, Gabriela;  Gohla, Antje;  Schneider-Stock, Regine 

Identification of DAPK as a scaffold protein for the LIMK/cofilin complex in TNF-induced apoptosis
In: International journal of biochemistry &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; cell biology. - Amsterdam : Elsevier, Bd. 45.2013, 8, S. 1720-1729

Koehler, Michael;  Fischer, Thomas;  Frommer, Jörg 

Caught by an acute leukaemia: Facing patients' own experiences
In: Leukemia research. - Amsterdam : Elsevier, Bd. 37.2013, 5, S. 481-482

Roeyen, Claudia R. C. van;  Scurt, Florian G.;  Brandt, Sabine;  Kuhl, Vanessa A.;  Martinkus, Sandra;  Djudjaj, Sonja;  Raffetseder, Ute;  Royer, Hans-Dieter;  Stefanidis, Ioannis;  Dunn, Sandra E.;  Dooley, Steven;  Weng, Honglei;  Fischer, Thomas;  Lindquist, Jonathan A.;  Mertens, Peter R. 

Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities
In: Cell communication and signaling. - London : Biomed Central; Bd. 11.2013, 1, Art.-Nr. 63, insges. 16 S.

Wagner, Marie-Christine;  Dziadosz, Marek;  Melo, Junia V.;  Heidel, Florian;  Fischer, Thomas;  Lipka, Daniel B. 

Nilotinib shows prolonged intracellular accumulation upon pulse-exposure: a novel mechanism for induction of apoptosis in CML cells. Letter to the editor
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 27.2013, 7, S. 1567-1570

Wolleschak, Denise;  Schalk, Enrico;  Krogel, Christian;  Schnoeder, Tina M.;  Luehr, Helga;  Jentsch-Ullrich, Kathleen;  Fischer, Thomas;  Heidel, Florian H. 

Rapid induction of complete molecular remission by sequential therapy with LDAC and sorafenib in FLT3-ITD-positive patients unfit for intensive treatment: two cases and review of the literature
In: Journal of hematology &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; oncology. - London : Biomed Central, Bd. 6.2013, insges. 6 S.

Nicht begutachteter Zeitschriftenartikel

Schalk, Enrico;  Wolleschak, Denise;  Fischer, Thomas 

Maligne Lymphome - Diagnostik und Therapie
In: Tumorzentrum aktuell // Tumorzentrum Magdeburg/Sachsen-Anhalt. - Magdeburg : Tumorzentrum, Bd. 10.2013, 1, S. 24-28

2012

Anderes Material

Korfel, Agnieszka;  Weller, Michael;  Martus, Peter;  Roth, Patrick;  Klasen, Hermann Ayke;  Roeth, Alexander;  Rauch, Michael;  Hertenstein, Bernd;  Fischer, Thomas;  Hundsberger, Thomas 

Prognostic impact of meningeal dissemination in primary CNS lymphoma (PCNSL) - experience from the G-PCNSL-SG1 trial
In: Annals of oncology: official journal of the European Society for Medical Oncology - Oxford: Oxford Univ. Press, Bd. 23.2012, 9, S. 2374-2380; http://dx.doi.org/10.1093/annonc/mdr627

Artikel in Zeitschrift

Arora, Deepika;  Köthe, Susanne;  Eijnden, Monique van den;  Huijsduijnen, Rob Hooft van;  Heidel, Florian;  Fischer, Thomas;  Scholl, Sebastian;  Tölle, Benjamin;  Böhmer, Sylvia-Annette;  Lennartsson, Johan;  Isken, Fabienne;  Müller-Tidow, Carsten;  Böhmer, Frank-D. 

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression
In: Cell communication and signaling - London: Biomed Central, Bd. 10.2012, Artikel-Nr. 19, insges. 15 S.; http://dx.doi.org/10.1186/1478-811X-10-19

Begutachteter Zeitschriftenartikel

Köhler, Michael;  Frommer, Jörg;  Flechtner, Hans-Henning;  Kropf, Siegfried;  Fischer, Thomas 

Strukturierte psychoonkologische Kurzintervention für Eltern Adoleszenter und junger Erwachsener (AYA) mit malignen hämatologischen Erkrankungen: eine randomisierte klinische Studie
In: Tumorzentrum aktuell // Tumorzentrum Magdeburg/Sachsen-Anhalt. - Magdeburg : Tumorzentrum, Bd. 9.2012, 1, S. 30-35

Wolleschak, Denise;  Fischer, Thomas;  Heidel, Florian 

Aktuelle und neue Therapieoptionen bei myeloproliferativen Erkrankungen
In: Tumorzentrum aktuell // Tumorzentrum Magdeburg/Sachsen-Anhalt. - Magdeburg : Tumorzentrum, Bd. 9.2012, 1, S. 21-29

Originalartikel in begutachteter internationaler Zeitschrift

Dziadosz, Marek;  Wagner, Marie-Christine;  Lipka, Daniel B.;  Fischer, Thomas;  Bartels, Heidemarie 

High-performance liquid chromatography with ultraviolet detection and protein precipitation as a way of quantitative determination of nilotinib with and without internal standard
In: Journal of liquid chromatography &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; related technologies. - Philadelphia, Pa. : Taylor &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Francis, Bd. 35.2012, 17, S. 2503-2510

Heidel, Florian H.;  Mack, Thomas S.;  Razumovskaya, Elena;  Blum, Marie-Christine;  Lipka, Daniel B.;  Ballaschk, Anne;  Kramb, Jan-Peter;  Plutizki, Stanislav;  Rönnstrand, Lars;  Dannhardt, Gerd;  Fischer, Thomas 

3,4-Diarylmaleimides - a novel class of kinase inhibitors - effectively induce apoptosis in FLT3-ITD-dependent cells
In: Annals of hematology. - Berlin : Springer, Bd. 91.2012, 3, S. 331-344

Kasper, Stefan;  Breitenbuecher, Frank;  Heidel, Florian;  Hoffarth, Sandra;  Markova, Boyka;  Schuler, Martin;  Fischer, Thomas 

Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies
In: Blood cancer journal. - London [u.a.] : Nature Publishing Group, Bd. 2.2012, 3, insges. 10 S.

Lipka, Daniel B.;  Wagner, Marie-Christine;  Dziadosz, Marek;  Schnöder, Tina;  Heidel, Florian;  Schemionek, Mirle;  Melo, Junia V.;  Kindler, Thomas;  Müller-Tidow, Carsten;  Koschmieder, Steffen;  Fischer, Thomas 

Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 7.2012, 7, insges. 16 S.

Stone, Richard M.;  Fischer, Thomas;  Paquette, Ronald;  Schiller, Gary;  Schiffer, Charles A.;  Ehninger, Gerhard;  Cortes, Jorge;  Kantarjian, Hagop M.;  DeAngelo, Daniel J.;  Huntsman-Labed, Alice;  Dutreix, Catherine;  DelCorral, A.;  Giles, Francis 

Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 26.2012, 9, S. 2061-2068

Zirm, Elisabeth;  Spies-Weisshart, Bärbel;  Heidel, Florian;  Schnetzke, Ulf;  Böhmer, Frank-Dietmar;  Hochhaus, Andreas;  Fischer, Thomas;  Scholl, Sebastian 

Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation
In: British journal of haematology. - Oxford [u.a.] : Wiley-Blackwell, Bd. 157.2012, 4, S. 483-492

2011

Originalartikel in begutachteter internationaler Zeitschrift

Fischer, Thomas 

Rethinking bioactivity of FLT3 inhibitors
In: Blood. - Washington, DC : American Society of Hematology, Bd. 117.2011, 12, S. 3247-3248

Köhler, Michael;  Köhler, Katharina;  Koenigsmann, Michael;  Kreutzmann, Nicole;  Fischer, Thomas;  Frommer, Jörg 

Beyond diagnosis: subjective theories of illness in adult patients with acute myeloid leukemia
In: Hematology. - London [u.a.] : Maney, Bd. 16.2011, 1, S. 5-13

2010

Originalartikel in begutachteter internationaler Zeitschrift

Fischer, Thomas;  Stone, Richard M.;  DeAngelo, Daniel J.;  Galinsky, Ilene;  Estey, Elihu;  Lanza, Carlo;  Fox, Edward;  Ehninger, Gerhard;  Feldman, Eric J.;  Schiller, Gary J.;  Klimek, Virginia M.;  Nimer, Stephen D.;  Gilliland, D. Gary;  Dutreix, Catherine;  Huntsman-Labed, Alice;  Virkus, Jodi;  Giles, Francis J. 

Phase IIB trial of oral midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3
In: Journal of clinical oncology . - Alexandria, Va. : American Society of Clinical Oncology, Bd. 28.2010, 28, S. 4339-4345

Giles, Francis J.;  Abruzzese, Elisabetta;  Rosti, Gianantonio;  Kim, Dong-Wook;  Bhatia, Ravi;  Bosly, André;  Goldberg, Stuart;  Kam, Grace L. S.;  Jagasia, Madan;  Mendrek, Wlodzimierz;  Fischer, Thomas;  Facon, Thierry;  Dünzinger, Ulrich;  Marin, David;  Müller, Martin C.;  Shou, Yaping;  Gallagher, Neil J.;  Larson, Richard A.;  Mahon, François-Xavier;  Baccarani, Michele;  Cortes, Jorge;  Kantarjian, Hagop M. 

Nilotinib is active in chronic and accelerated phase chronic myeloid leukemia following failure of imatinib and dasatinib therapy
In: Leukemia . - Basingstoke : Nature Publ. Group, Bd. 24.2010, 7, S. 1299-1301

Josting, Andreas;  Müller, Horst;  Borchmann, Peter;  Baars, Joke W.;  Metzner, Bernd;  Döhner, Hartmut;  Aurer, Igor;  Smardova, Lenka;  Fischer, Thomas;  Niederwieser, Dietger;  Schäfer-Eckart, Kerstin;  Schmitz, Norbert;  Sureda, Anna;  Glossmann, Jan;  Diehl, Volker;  DeJong, Daphne;  Hansmann, Martin-Leo;  Raemaekers, John;  Engert, Andreas 

Dose intensity of chemotherapy in patients with relapsed Hodgkin's lymphoma
In: Journal of clinical oncology . - Alexandria, Va. : American Society of Clinical Oncology, Bd. 28.2010, 34, S. 5074-5080

Kindler, Thomas;  Lipka, Daniel;  Fischer, Thomas 

FLT3 as a therapeutic target in AML: still challenging after all these years
In: Blood . - Washington, DC : American Society of Hematology, Bd. 116.2010, 24, S. 5089-5102

Krogel, Christian;  Fischer, Thomas;  Heidel, Florian 

Severe paraneoplastic pemphigus in a patient with follicular lymphoma
In: European journal of haematology . - Oxford : Wiley-Blackwell, Bd. 84.2010, 4, S. 365, insges. 1 S.

Markova, Boyka;  Albers, Corinna;  Breitenbücher, Frank;  Melo, Junia V.;  Brümmendorf, Tim H.;  Heidel, Florian;  Lipka, Daniel;  Duyster, Justus;  Huber, Christoph;  Fischer, Thomas 

Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-[gamma]1-driven activation of mTOR/p70S6-kinase pathway
In: Oncogene . - Basingstoke : Nature Publ. Group, Bd. 29.2010, 5, S. 739-751

Originalartikel in begutachteter nationaler Zeitschrift

Rüsseler, Anna Vanessa;  Brors, Benedikt;  Fischer, Thomas;  Hartmann, Jörg T.;  Hartmann, Wolfgang;  Hohenberger, Peter;  Lichter, Peter;  Marx, Alexander;  Mechtersheimer, Gunhild;  Penzel, Roland;  Renner, Marcus;  Schildhaus, Hans-Ulrich;  Schirmacher, Peter;  Sievers, Elisabeth;  Ströbel, Philipp;  Wardelmann, Eva;  Ziesché, Elisabeth;  Büttner, Reinhard 

Molekularpathologie von Sarkomen: Erste Ergebnisse des Sarkomforschungsverbundes KoSar
In: Der Pathologe : Organ der Deutschen Abteilung der Internationalen Akademie für Pathologie, der Deutschen, der Österreichischen und der Schweizerischen Gesellschaft für Pathologie und des Berufsverbandes Deutscher Pathologen. - Heidelberg : Springer-Medizin-Verl; Bd. 31.2010, Suppl.2, S. 211-214

2009

Nicht begutachteter Zeitschriftenartikel

Köhler, Michael;  Bölter, Annette;  Lange, Julia;  Dogan, Elif;  Heine, Viktoria;  Fischer, Thomas;  Frommer, Jörg 

Krebspatienten brauchen ein individuelles psychologisches Angebot - 2. Magdeburger Psychoonkologisches Kolloquium
In: Ärzteblatt Sachsen-Anhalt . - Magdeburg : Ärztekammer Sachsen-Anhalt, Bd. 20.2009, 4, S. 50-54

Originalartikel in begutachteter internationaler Zeitschrift

Breitenbuecher, F;  Markova, B;  Kasper, S;  Carius, B;  Stauder, T;  Kindler, T;  Böhmer, F;  Huber, C;  Fischer, Thomas 

A Novel Molecular Mechanism of Primary Resistance to FLT3-Kinase Inhibitors in Acute Myeloid Leukaemia.
In: Blood 2009 Apr 23;113(17):4063-73. Epub 2009 Jan 14.

Breitenbuecher, F;  Schnittger, S;  Grundler, R;  Markova, B;  Carius, B;  Brecht, A;  Duyster, J;  Haferlach, T;  Huber, C;  Fischer, Thomas 

Identification of a Novel Type of ITD Mutations Located in Non-Juxtamembrane Domains of the FLT3 Tyrosine Kinase Receptor.
In: Blood 2009 Apr 23;113(17):4074-7. Epub 2008 May 15.

Dickinson, Michael;  Ritchie, David;  DeAngelo, Daniel J.;  Spencer, Andrew;  Ottmann, Oliver G.;  Fischer, Thomas;  Bhalla, Kapil N.;  Liu, Angela;  Parker, Katie;  Scott, Jeffrey W.;  Bishton, Mark;  Prince, H. Miles 

Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin lymphoma
In: British journal of haematology . - Oxford [u.a.] : Wiley-Blackwell, Bd. 147.2009, 1, S. 97-101

Heidel, Florian;  Lipka, Daniel;  Mirea, Fian K.;  Mahboobi, Siavosh;  Grundler, Rebekka;  Kancha, Rama K.;  Duyster, Justus;  Naumann, Michael;  Huber, Christoph;  Böhmer, Frank D.;  Fischer, Thomas 

Bis(1H-indol-2-yl)methanones are effective inhibitors of FLT3-ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro
In: British journal of haematology . - Oxford [u.a.] : Wiley-Blackwell, Bd. 144.2009, 6, S. 865-874

Kayser, Sabine;  Schlenk, Richard F.;  Londono, Martina Correa;  Breitenbücher, Frank;  Wittke, Kerstin;  Du, Juan;  Groner, Silja;  Späth, Daniela;  Krauter, Jürgen;  Ganser, Arnold;  Döhner, Hartmut;  Fischer, Thomas;  Döhner, Konstanze 

Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
In: Blood . - Washington, DC : American Society of Hematology, Bd. 114.2009, 12, S. 2386-2392

2008

Originalartikel in begutachteter internationaler Zeitschrift

Hochhaus A;  Druker B;  Sawyers C;  Guilhot F;  Schiffer C A;  Cortes J;  Niederwieser D W;  Gambacorti C;  Stone R M;  Goldman J;  Fischer, T;  O'Brien S G;  Reiffers, J J;  Mone M;  Krahnke T;  Talpaz M;  Kantarjian H M 

Favorable long-term follow-up results over six years for response, survival and safety with imatinib mesylate therapy in chronic phase chronic myeloid leukemia post failure of interferon-alpha treatment.
In: Blood 111(3):1039-43, 2008

Kasper, S;  Breitenbuecher, F;  Kindler, T;  Heidel, Florian;  Lipka, Daniel;  Elliot, J;  Huber, C;  Fischer, Thomas 

The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukaemia.
In: Leuk Res. 2008 Nov;32(11):1698-708. Epub 2008 Jun 16.

Lipka, Daniel;  Heidel, Florian;  Huber, C;  Fischer, Thomas 

Entwicklung von Tyrosinkinase-Inhibitoren bei hämatologischen Neoplasien. FLT3 und JAK2 als therapeutische Targets.
In: Pharm Unserer Zeit. 2008;37(5):394-403.

Lipka, Daniel;  Hoffmann, L S;  Heidel, Florian;  Markova, B;  Blum, M -C;  Breitenbuecher, F;  Kasper, S;  Kindler, T;  Levine, R L;  Huber, C;  Fischer, Thomas 

LS104, a non ATP-competitive small molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2-V617F positive cells.
In: Mol Cancer Ther 7(5): 1176-1184, 2008.

2007

Originalartikel in begutachteter internationaler Zeitschrift

Deininger, M;  Cortes, J;  Paquette, R;  Park ,B;  Niederwieser, D;  Stone, R;  Hochhaus, A;  Reiffers, J;  Fischer, Thomas;  Kantarjian, H;  Baccarani, M;  Gambacorti-Passerini, C;  So, C;  Krahnke, T;  Gathmann, I;  Druker, D;  Smith Brian;  Guilhot, F 

The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells.
In: Cancer 110:1509-19, 2007.

Drescher, D;  Moehler, M;  Gockel, I;  Frerichs, K;  Müller, A;  Biesterfeld ,S;  Holtmann, M;  Mudter, J;  Wehler, T;  Fischer, T;  Junginger, T;  Galle, P R;  Schimanski, C C 

Co-expression of tyrosine kinase receptors in gastric adenocarcinoma ¿ a rationale for a new molecular targeting strategy?
In: World J Gastroenterol 13(26):3605-9, 2007.

Frühauf, S;  Topaly, J;  Buss, E;  Fischer, T;  Ottmann, O;  Emmerich, B;  Müller, M;  Schuld, P;  Balleisen, L;  Hehlmann, R;  Ho, A;  Hochaus ,A 

Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukaemia in myeloid blast crisis.
In: Cancer 109:1543-9, 2007.

Graf, C;  Heidel, F;  Tenzer, S;  Radsak, M;  Solem, F;  Britten, C;  Huber, C;  Fischer, Thomas;  Wölfel, T 

A neoepitope generated by a FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T-cells.
In: Blood 109(7):2985-2988, 2007.

Hehlmann, R;  Berger, U;  Pfirrmann, M;  Heimpel, H;  Hochhaus, A;  Hasford, J;  Kolb, HJ;  Lahaye, T;  Maywald, O;  Reiter, A;  Hossfeld, DK;  Huber, C;  Löffler, H;  Pralle, H;  Queisser, W;  Tobler, A;  Nerl, C;  Solenthaler, M;  Goebeler, ME;  Griesshammer, M;  Fischer, Thomas;  Kremers, S;  Eimermacher, H;  Pfreundschuh, M;  Hirschmann, WD;  Lechner, K;  Wassmann, B;  Falge, C;  Kirchner, HH;  Gratwohl ,A. 

Drug treatment is superior to allografting as first line therapy in chronic myeloid leukemia.
In: Blood 109:4686-92, 2007

Heidel, F;  Cortes, J;  Rücker, F G;  Aulitzky, W;  Letvak, L;  Kindler, T;  Huber, C;  Döhner, H;  Kantarjian, H;  Fischer, T 

Results of a multicenter phase II trial for older patients with c-kit positive acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) using low-dose Ara-C (LDAC) and Imatinib (IM).
In: Cancer 109(5):907-14, 2007.

Kasper, S;  Kindler, T;  Breitenbücher, F;  Sonnenschein, S;  Böhmer, Frank D;  Huber,C;  Fischer, Thomas 

Cross-inhibition of IFN-induced signal transduction by GM-CSF through a block in STAT1- activation.
In: J Interferon Cytokine Res 27(11):947-59, 2007.

2006

Originalartikel in begutachteter internationaler Zeitschrift

Druker, B J;  Guilhot, F;  O'Brien, S G;  Gathmann, I;  Kantarjian, H;  Gattermann, N;  Deininger, M W N;  Silver, R T;  Goldman, J M;  Stone ,R M;  Cervantes, F;  Hochhaus, A;  Powell, B L;  Gabrilove, J L;  Rousselot, P;  Reiffers ,J;  Cornelissen, J J;  Hughes, T;  Agis, H;  Fischer, Thomas;  Verhoef, G;  Shepherd, J;  Saglio, G;  Gratwohl, A;  Nielsen, JL;  Radich, JP;  Simonsson, B;  Taylor, K;  Baccarani, M;  So C;  Letvak, L;  Larson, RA;  IRIS Investigators 

Five-Year Follow-up of Imatinib Therapy for Newly Diagnosed Chronic Myeloid Leukemia in Chronic-Phase Shows Sustained Responses and High Overall Survival.
In: New England Journal of Medicine 355:2408-17, 2006

Giles, F;  Fischer, T;  Cortes, J;  Garcia-Manero, G;  Beck, J;  Ravandi, F;  Masson, E;  Rae, P;  Laird, G;  Sharma, S;  Kantarjian, H;  Dugan, M;  Albitar, M;  Bhalla, K 

A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
In: Clinical Cancer Research 1;12(15):4628-35, 2006.

Heidel, F;  Solem, F K;  Breitenbuecher, F;  Lipka, D B;  Kasper, S;  Thiede, H M;  Serve, C Brandts, H;  Roesel, J;  Giles, F;  Feldman, E;  Ehninger, G;  Schille, G J;  Nimer, S;  Stone ,R M;  Kindler, T;  Cohen, P S;  Huber, C;  Fischer, Thomas 

Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia (AML) by mutation of Asn-676 in the FLT3 tyrosine kinase domain.
In: Blood 107(1):293-300, 2006.

Mahboobi, S;  Uecker, A;  Sellmer, A;  Cénac, C;  Höcher, H;  Pongratz, H;  Eichhorn, E;  Hufsky, H;  Trümpler, A;  Sicker, M;  Heidel Florian;  Fischer, Thomas;  Stocking, C;  Elz, S;  Böhmer, FD;  Dove, S 

Novel Bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinases.
In: Journal of Medicinal Chemistry 49: 3101-3115, 2006.

Schuchmann, M;  Schulze-Bergkamen, H;  Fleischer, B;  Schattenberg, J;  Siebler, J;  Weinmann, A;  Teufel, A;  Wörns, M;  Fischer, T;  Strand, S;  Lohse, A W;  Galle, P R 

Histone deacetylase inhibition by valproic acid downregulates c-FLIP and sensitizes hepatoma cells towards CD95- and TRAIL-receptor mediated apoptosis and chemotherapy.
In: Oncology Reports 15: 227-230, 2006.

Kooperationen
Profil
  • Hämatologie/Onkologie
  • Innere Medizin
  • Onkogene Signaltransduktion
Service
Beratung, Diagnostik und Therapie:
  • bei gutartigen und bösartigen hämatologischen Erkrankungen;
  • bei Leukämien, myelodysplastischem Syndrom, myeloproliferativen Neoplasien, Lymphomen, Multiplem Myelom (Plasmozytom);
  • bei Tumorerkrankungen;
  • bei Weichteilsarkomen;
  • bei sogenanntem CUP -Syndrom.

  Beratung zur hämatopoetischen Stammzelltransplantation
Vita
STUDIUM
1980 - 1981Rumänisch Studium an der Universität Craiova, Rumänien
1981 - 1982Medizinstudium an der Universität Cluj, Rumänien
1982 - 1983Medizinstudium an der Georg-August-Universität Göttingen
1983 - 1984Medizinstudium an der Medizinischen Hochschule Hannover
1985Stipendiat der Soltenborn-Stiftung
1984 - 1987Medizinstudium an der Georg-August-Universität Göttingen
1987 - 1988Praktisches Jahr: Tufts University, Boston, USA (Stipendiat des "Biomedical Sciences Exchange Program between The United States and West Germany"); Krh. Seesen; Krh. Bad Harzburg

AKADEMISCHE GRADE
1988Promotion zum Dr. med. an der Georg-August-Universität Göttingen,   Bewertung: Magna cum laude
2000Habilitation und venia legendi für das Fach "Innere Medizin" am Fachbereich Medizin der Johannes Gutenberg-Universität Mainz (Molekulare Untersuchungen zur Signaltransduktion IFN-induzierter Gene in leukämischen und normalen hämatopoetischen Zellen)

BERUFLICHER WERDEGANG
10/1988 - 3/1990DFG-Postdoktorandenstipendium in der klinischen Arbeitsgruppe der Max-Planck-Gesellschaft an der Medizinischen Universitätsklinik Göttingen (Leiter: Prof. Dr. K. Pfizenmaier)
4/1990 - 9/1990"Postdoctoral Research Fellowship am "Hospital for Sick Children , Toronto, Kanada (Prof. Dr. B. Williams)
10/1990 - 11/1996Assistent an der III. Medizinischen Klinik der Johannes-Gutenberg-Universität Mainz (Direktor: Prof. Dr. C. Huber)
1/1995 - 12/1995"Clinical Fellowship in Hämatologie/Onkologie am "Department for Hematology and Medical Oncology , Cleveland Clinic Foundation, Cleveland, USA
5/1996Facharzt-Anerkennung Arzt für Innere Medizin
12/1996 - 6/2008Oberarzt und Arbeitsgruppenleiter an der Medizinischen Klinik der Johannes Gutenberg-Universität Mainz. Aufbau und Leitung des wissenschaftlichen Labors für Onkogene Signaltransduktion.
1/1998Anerkennung Hämatologie und Internistische Onkologie
3/2001- 4/2004Medical Director und Vertreter von Prof. Dr. med. Christoph Huber an der III. Medizinischen Klinik und Poliklinik der Johannes Gutenberg-Universität Mainz. Strategisches, operatives, wirtschaftliches, personalführendes und administratives "Management" der III. Medizinischen Klinik und Poliklinik.
3/2005Berufung auf eine Professur (W2) für "Leukämie- und Tumorforschung" im Fachbereich Medizin der Johannes Gutenberg-Universität Mainz an der III. Medizinischen Klinik und Poliklinik (Stiftungsprofessur).
Seit 5/2009Univ.-Professor (W3) und Direktor der Klinik für Hämatologie und Onkologie an der Otto-von-Guericke-Universität Magdeburg
presse

Letzte Änderung: 22.08.2018 - Ansprechpartner: Webmaster